# STOCKHOLM 1.0
#=GF ID ACD
#=GF AC PF16671.6
#=GF DE Actin cross-linking domain
#=GF AU Eberhardt R;0000-0001-6152-1369
#=GF GA 27.0 27.0
#=GF NC 20.5 20.4
#=GF TC 57.2 56.0
#=GF SE PDB:4e1f
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 22898822
#=GF RT Crystal structure of the VgrG1 actin cross-linking domain of the
#=GF RT Vibrio cholerae  type VI secretion system.
#=GF RA Durand E, Derrez E, Audoly G, Spinelli S, Ortiz-Lombardia M,
#=GF RA Raoult D, Cascales E, Cambillau C;
#=GF RL J Biol Chem. 2012;287:38190-38199.
#=GF DR INTERPRO; IPR032074;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This domain is found in Vibrio cholerae RtxA toxin and VgrG1
#=GF CC protein. This domain cross-links to G-actin leading to
#=GF CC cytoskeletal changes [1].
#=GF SQ 5
A0KHZ7.1/1942-2327     KAVPEFSSHFDGSSIGIENELTGLVVALPKNSAQKFGYVHDA.AGNPLFMLTKDMNQGGYTNPAGISDVKGINQWQTHTIELVTYPSEMQDQQAVEARKEAMLWLAREFTQHISQTNHTRLSDLVSEDGRFTLVISNANHVIAAGNGAARDGQGQTIGMTPSGQQATVAVSAKAFGS.GSSQEIRLLESAPWYHPELKDLLLSNMANVQWEDAATAQNVFAYLTSIYGKTADLAREYGIHINDWDPLAEGITPNAQGLTDPKVKNAWEILPRTKPVAMLALLSAHDRKLVSEQILATLKSAYSPALAQNIYDYFKFGGEVAGHGINNATTGDSKHPEPAILFEFRQVPNELSQFVPKSESTARVEVKTLDQFDPVSRRTIVAAVNNLV
Q9KS12.2/1986-2371     KSVPGFKSHFASTSIGIENELSGLVVVLPKNSAQTFGYVHDS.QGNPLFMLTKDMNQGGYSNPVGINDIQGVNNWQTHTIELVTYPSEISDTAAVESRKEAMLWLAKEFTDHINQSNHQSLPHLVSDDGRFTLVISNSKHLIAAGNGTSIDAQGKTIGMTPSGQQATMAISAKEFGT.SSSPEVRLLESAPWYQAGLRDEFLANAKNTTLDDPATAQNVYAYLTSVYSKTADLAKEYGIYINDWDPASEGFSPNAQGLTDPKVKNAWSILPRTKPVRMLELLSAEDSRYVRQQIAEKLKGTYSESLAKNVFEYFQYGGEVAGHGINNATTGSVQQPEPAILFEFRSVPSALSDFVPKTASTVKVDVKALDHFDSASRKAIITEVNALV
Q9KS45.1/726-1111      KATPDFPTHFPKSSIGIENELAGLVVAMPANSAQKFGYVKSA.QGDALFMLTKDMNQGSYQRPPSLQDGKNYQNWQTHTVELVSYPCEMDDKAAVETRKQAMLWLATHFTTHIDQSNHQPLAPIQSEDGRFVIEITNAKHVIAAGNGISAESQGQTITMTPSGQQATVGVAAKGFGT.SATPELRLLESAPWYQKSLKSQFASLTSAENLDDKELAANVFAYLTSIYLKTAELAKKFGIYINEWDPMSEQITPNANGLTDPKVKNAWEILPRTKPSKIVEILSKSDAKAVMKHIKPQLQSRYSESLSKNVFQYFQDGGEVAGHGINNATVGDKHSPELAILFEFRTVPNELQSYLPKTESTTKSEVKLLDQFDPMKRKTVIQQVESLV
A0A2G9DK76.1/2869-3238 --APGFPSSFGSTSLGTESELSGFVVAVPQNADRTFAFVQRVdTGEPLVMVTKDMGQGAYGNPAKLAAAE-RGNWQTHTVELVTYPSRFGDEAALADRDGATRFLLDVFRDRLGTHNHAPLASLVSPDGQFRLQVTNDRHVIAAGRGMDLEEQP-SVSMPSGQQQATVGVRASELGApGSADSALLLDHAPWFRADFRQDEALRAVAATADAPERVENAYTYLKSVVSFLSDLVKKHDIPLGEYPG-------AGRALTHPQVKNDWKVLPRTRPNLILGTLSDHDRAL-TQRLLRETAPLGDETIWKEVRQYVMGGGAVAGHGIDKATIA----GEQALLFEFRELPDRLLPYVPREAAPTVAVSDPLAGLG-GRRIAVIREVNEF-
A0A1H9MRZ7.1/9-316     -----YRSEFAGPSVGTEQELLGVRIGRKASGGSEIADVV-S.GGQVLVQITTDIGGGG-DAPFG---------YLGYTMEIKTSPTEVTDVAGWELRRGAIREVIAAIADMVLVK---GGSFTGGKLGAYDLVVHNGDHVVYGADTLST-------GVSGSSRHATFGLPFALLGT.EH---AALVSKAGWYE-DWSEEFDLIEGSSPWVDRDRSLRVYNYLRSVLTRLARLTSDYSLAVHDLYDL-KGFTGN---LYDSAIKNRWGVLPRTSPWVAIELLAKSDRERIRPTLLKCPSRVTDPVIWSAAVSHITQHRSLAGHTPKAPTYTEEELP--GTLFEFRT------------------------------------------
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