Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
82  structures 3726  species 0  interactions 8888  sequences 86  architectures

Family: ADH_N_2 (PF16884)

Summary: N-terminal domain of oxidoreductase

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

N-terminal domain of oxidoreductase Provide feedback

N-terminal region of oxidoreductase and prostaglandin reductase and alcohol dehydrogenase.

Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR041694

This is the N-terminal domain of prostaglandin reductase and other oxidoreductases.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

Loading domain graphics...

Pfam Clan

This family is a member of clan GroES (CL0296), which has the following description:

This superfamily includes the GroES protein as well as the N-terminal GroES-like domain from Alcohol dehydrogenase.

The clan contains the following 3 members:

ADH_N ADH_N_2 Cpn10

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(54)
Full
(8888)
Representative proteomes UniProt
(28177)
RP15
(1006)
RP35
(3953)
RP55
(8059)
RP75
(13245)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(54)
Full
(8888)
Representative proteomes UniProt
(28177)
RP15
(1006)
RP35
(3953)
RP55
(8059)
RP75
(13245)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(54)
Full
(8888)
Representative proteomes UniProt
(28177)
RP15
(1006)
RP35
(3953)
RP55
(8059)
RP75
(13245)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Manual:Q14914
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Coggill P
Number in seed: 54
Number in full: 8888
Average length of the domain: 107.00 aa
Average identity of full alignment: 30 %
Average coverage of the sequence by the domain: 31.43 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 31.0 31.0
Trusted cut-off 31.0 31.0
Noise cut-off 30.9 30.9
Model length: 108
Family (HMM) version: 7
Download: download the raw HMM for this family

Species distribution

Sunburst controls

Hide

Weight segments by...


Change the size of the sunburst

Small
Large

Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

Align selected sequences to HMM

Generate a FASTA-format file

Clear selection

This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

Loading sunburst data...

Tree controls

Hide

The tree shows the occurrence of this domain across different species. More...

Loading...

Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the ADH_N_2 domain has been found. There are 82 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

Loading structure mapping...

AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0P0Y895 View 3D Structure Click here
A0A0R0KSS1 View 3D Structure Click here
A0A0R4J5U6 View 3D Structure Click here
A0A1D5NSP9 View 3D Structure Click here
A0A1D6N563 View 3D Structure Click here
A0A1D6PRV1 View 3D Structure Click here
A0A1D8PMM8 View 3D Structure Click here
A0A2R8RPQ9 View 3D Structure Click here
C0PGX3 View 3D Structure Click here
C0PJR9 View 3D Structure Click here
C6TIQ5 View 3D Structure Click here
C6TKH5 View 3D Structure Click here
F4IBH8 View 3D Structure Click here
I1JMF6 View 3D Structure Click here
I1JMF7 View 3D Structure Click here
I1JMF8 View 3D Structure Click here
I1LU49 View 3D Structure Click here
K7KDY8 View 3D Structure Click here
K7KWL3 View 3D Structure Click here
K7M2W5 View 3D Structure Click here
K7TK74 View 3D Structure Click here
K7UXK5 View 3D Structure Click here
K7VET5 View 3D Structure Click here
K7VVX9 View 3D Structure Click here
P76113 View 3D Structure Click here
P97584 View 3D Structure Click here
Q03102 View 3D Structure Click here
Q0G840 View 3D Structure Click here
Q14914 View 3D Structure Click here
Q2G2D7 View 3D Structure Click here
Q2QVJ5 View 3D Structure Click here
Q2QVJ6 View 3D Structure Click here
Q2QVJ8 View 3D Structure Click here
Q2QVK7 View 3D Structure Click here
Q39172 View 3D Structure Click here
Q39173 View 3D Structure Click here
Q53LC7 View 3D Structure Click here
Q54LY2 View 3D Structure Click here
Q54LY4 View 3D Structure Click here
Q59ZH5 View 3D Structure Click here
Q5BK81 View 3D Structure Click here
Q69XJ5 View 3D Structure Click here
Q7XUK3 View 3D Structure Click here
Q869N3 View 3D Structure Click here
Q8LPM0 View 3D Structure Click here
Q8N8N7 View 3D Structure Click here
Q8S0M7 View 3D Structure Click here
Q8VDQ1 View 3D Structure Click here
Q91YR9 View 3D Structure Click here
Q93Z72 View 3D Structure Click here
Q9C0Y6 View 3D Structure Click here
Q9C677 View 3D Structure Click here
Q9FKC9 View 3D Structure Click here
Q9FKD2 View 3D Structure Click here
Q9LFK5 View 3D Structure Click here
Q9LTB4 View 3D Structure Click here
Q9M9M7 View 3D Structure Click here
X1WFL9 View 3D Structure Click here