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7  structures 449  species 0  interactions 10326  sequences 272  architectures

Family: fn3_6 (PF17766)

Summary: Fibronectin type-III domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Fibronectin type-III domain Provide feedback

This FN3 like domain is found at the C-terminus of cucumisin proteins [1].

Literature references

  1. Murayama K, Kato-Murayama M, Hosaka T, Sotokawauchi A, Yokoyama S, Arima K, Shirouzu M;, J Mol Biol. 2012;423:386-396.: Crystal structure of cucumisin, a subtilisin-like endoprotease from Cucumis melo L. PUBMED:22841692 EPMC:22841692


Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR041469

This FN3 (fibronectin type-III) like domain is found at the C terminus of subtilisin-like proteases, such as the cucumisin protein [ PUBMED:22841692 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan E-set (CL0159), which has the following description:

This clan includes a diverse range of domains that have an Ig-like fold and appear to be distantly related to each other. The clan includes: PKD domains, cadherins and several families of bacterial Ig-like domains as well as viral tail fibre proteins. it also includes several Fibronectin type III domain-containing families.

The clan contains the following 238 members:

A2M A2M_BRD A2M_recep AA9 Adeno_GP19K AlcCBM31 Alpha-amylase_N Alpha_adaptinC2 Alpha_E2_glycop Anth_Ig Arch_flagellin aRib Arylsulfotran_N ASF1_hist_chap ATG19 BACON BACON_2 BatD BIg21 Big_1 Big_10 Big_11 Big_12 Big_13 Big_2 Big_3 Big_3_2 Big_3_3 Big_3_4 Big_3_5 Big_4 Big_5 Big_6 Big_7 Big_8 Big_9 Bile_Hydr_Trans BiPBP_C bMG1 bMG10 bMG3 bMG5 bMG6 BslA BsuPI Cadherin Cadherin-like Cadherin_2 Cadherin_3 Cadherin_4 Cadherin_5 Cadherin_pro CagX Calx-beta Candida_ALS_N CARDB CBM39 CBM_X2 CD45 CelD_N Ceramidse_alk_C CHB_HEX_C CHB_HEX_C_1 ChitinaseA_N ChiW_Ig_like Chlam_OMP6 CHU_C Coatamer_beta_C COP-gamma_platf CopC CshA_repeat Cyc-maltodext_N Cytomega_US3 DsbC DUF11 DUF1410 DUF1425 DUF1929 DUF2271 DUF3244 DUF3327 DUF3416 DUF3458 DUF3501 DUF3823_C DUF3859 DUF4165 DUF4179 DUF4426 DUF4469 DUF4625 DUF4879 DUF4959 DUF4981 DUF4982 DUF4998 DUF5001 DUF5008 DUF5011 DUF5065 DUF5115 DUF525 DUF5643 DUF6383 DUF916 EB_dh ECD EpoR_lig-bind ERAP1_C EstA_Ig_like Expansin_C Filamin FixG_C Flavi_glycop_C FlgD_ig fn3 Fn3-like fn3_2 fn3_4 fn3_5 fn3_6 FN3_7 Fn3_assoc fn3_PAP GBS_Bsp-like Glucodextran_B Glyco_hydro2_C5 Glyco_hydro_2 Gmad2 GMP_PDE_delta GPI-anchored Hanta_G1 He_PIG HECW_N HemeBinding_Shp Hemocyanin_C Herpes_BLLF1 HYR IFNGR1 Ig_GlcNase Ig_mannosidase IL12p40_C Il13Ra_Ig IL17R_fnIII_D1 IL17R_fnIII_D2 IL2RB_N1 IL3Ra_N IL4Ra_N IL6Ra-bind Inhibitor_I42 Inhibitor_I71 InlK_D3 Integrin_alpha2 Interfer-bind Invasin_D3 IRK_C IrmA Iron_transport LEA_2 Lep_receptor_Ig LIFR_N Lipase_bact_N LPMO_10 LRR_adjacent LTD Mannosidase_ig MetallophosC MG1 MG2 MG3 MG4 Mo-co_dimer N_BRCA1_IG Na_K-ATPase NEAT Neocarzinostat Neurexophilin NPCBM_assoc PapD_C PBP-Tp47_c Peptidase_C25_C Phlebo_G2_C PhoD_N PKD PKD_2 PKD_3 PKD_4 PKD_5 PKD_6 Por_Secre_tail Pox_vIL-18BP Psg1 PTP_tm Pur_ac_phosph_N Qn_am_d_aII Qn_am_d_aIII RabGGT_insert Reeler REJ RET_CLD1 RET_CLD3 RET_CLD4 RGI_lyase RHD_dimer Rho_GDI Rib RibLong SCAB-Ig SKICH SLAM SoxZ SprB SusE SVA SWM_repeat T2SS-T3SS_pil_N Tafi-CsgC TarS_C1 TcA_RBD TcfC TIG TIG_2 TIG_plexin TIG_SUH Tissue_fac Top6b_C Transglut_C Transglut_N TRAP_beta TraQ_transposon UL16 Velvet WIF Wzt_C Y_Y_Y YBD ZirS_C Zona_pellucida

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(167)
Full
(10326)
Representative proteomes UniProt
(15578)
RP15
(853)
RP35
(5465)
RP55
(8673)
RP75
(11651)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(167)
Full
(10326)
Representative proteomes UniProt
(15578)
RP15
(853)
RP35
(5465)
RP55
(8673)
RP75
(11651)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(167)
Full
(10326)
Representative proteomes UniProt
(15578)
RP15
(853)
RP35
(5465)
RP55
(8673)
RP75
(11651)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: ECOD:EUF05011
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A
Number in seed: 167
Number in full: 10326
Average length of the domain: 97.60 aa
Average identity of full alignment: 34 %
Average coverage of the sequence by the domain: 13.74 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 26.4 26.4
Trusted cut-off 26.4 26.5
Noise cut-off 26.2 26.3
Model length: 99
Family (HMM) version: 3
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the fn3_6 domain has been found. There are 7 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0P0V749 View 3D Structure Click here
A0A0P0V984 View 3D Structure Click here
A0A0P0VAS5 View 3D Structure Click here
A0A0P0VHD1 View 3D Structure Click here
A0A0P0VHE8 View 3D Structure Click here
A0A0P0VTL0 View 3D Structure Click here
A0A0P0VYZ5 View 3D Structure Click here
A0A0P0W669 View 3D Structure Click here
A0A0P0W683 View 3D Structure Click here
A0A0P0W6P0 View 3D Structure Click here
A0A0P0W6Q2 View 3D Structure Click here
A0A0P0W6R0 View 3D Structure Click here
A0A0P0W6V1 View 3D Structure Click here
A0A0P0WYV3 View 3D Structure Click here
A0A0P0XEJ6 View 3D Structure Click here
A0A0P0XGM3 View 3D Structure Click here
A0A0P0XUA3 View 3D Structure Click here
A0A0R0F2A2 View 3D Structure Click here
A0A0R0F403 View 3D Structure Click here
A0A0R0F430 View 3D Structure Click here
A0A0R0F591 View 3D Structure Click here
A0A0R0F6R4 View 3D Structure Click here
A0A0R0FFE9 View 3D Structure Click here
A0A0R0FG78 View 3D Structure Click here
A0A0R0FI48 View 3D Structure Click here
A0A0R0FJI5 View 3D Structure Click here
A0A0R0FK40 View 3D Structure Click here
A0A0R0FK42 View 3D Structure Click here
A0A0R0FN77 View 3D Structure Click here
A0A0R0FUL7 View 3D Structure Click here
A0A0R0GGN1 View 3D Structure Click here
A0A0R0GH92 View 3D Structure Click here
A0A0R0GJF4 View 3D Structure Click here
A0A0R0H350 View 3D Structure Click here
A0A0R0HBM9 View 3D Structure Click here
A0A0R0HDM6 View 3D Structure Click here
A0A0R0HDV7 View 3D Structure Click here
A0A0R0HS84 View 3D Structure Click here
A0A0R0HXS4 View 3D Structure Click here
A0A0R0I8R4 View 3D Structure Click here
A0A0R0IAN9 View 3D Structure Click here
A0A0R0IGS6 View 3D Structure Click here
A0A0R0IKE9 View 3D Structure Click here
A0A0R0J5L4 View 3D Structure Click here
A0A0R0JR01 View 3D Structure Click here
A0A0R0K1X6 View 3D Structure Click here
A0A0R0K2N4 View 3D Structure Click here
A0A0R0K6T3 View 3D Structure Click here
A0A0R0L1C5 View 3D Structure Click here
A0A0R4J339 View 3D Structure Click here
A0A0R4J5Q8 View 3D Structure Click here
A0A1D6E3K3 View 3D Structure Click here
A0A1D6E3K4 View 3D Structure Click here
A0A1D6E4A2 View 3D Structure Click here
A0A1D6EAQ6 View 3D Structure Click here
A0A1D6ECS6 View 3D Structure Click here
A0A1D6F706 View 3D Structure Click here
A0A1D6FPN2 View 3D Structure Click here
A0A1D6GAL4 View 3D Structure Click here
A0A1D6GUX8 View 3D Structure Click here
A0A1D6H400 View 3D Structure Click here
A0A1D6HFE8 View 3D Structure Click here
A0A1D6HM48 View 3D Structure Click here
A0A1D6HM49 View 3D Structure Click here
A0A1D6HUV7 View 3D Structure Click here
A0A1D6HUV8 View 3D Structure Click here
A0A1D6HUV9 View 3D Structure Click here
A0A1D6HXI1 View 3D Structure Click here
A0A1D6I1L9 View 3D Structure Click here
A0A1D6I6P5 View 3D Structure Click here
A0A1D6I7N0 View 3D Structure Click here
A0A1D6I9M3 View 3D Structure Click here
A0A1D6INV6 View 3D Structure Click here
A0A1D6JLG5 View 3D Structure Click here
A0A1D6JNE6 View 3D Structure Click here
A0A1D6JP43 View 3D Structure Click here
A0A1D6JVP9 View 3D Structure Click here
A0A1D6KW13 View 3D Structure Click here
A0A1D6KWW2 View 3D Structure Click here
A0A1D6L5J9 View 3D Structure Click here
A0A1D6LCF9 View 3D Structure Click here
A0A1D6MQX9 View 3D Structure Click here
A0A1D6N9J8 View 3D Structure Click here
A0A1D6NAI7 View 3D Structure Click here
A0A1D6NDF4 View 3D Structure Click here
A0A1D6NEK4 View 3D Structure Click here
A0A1D6PL21 View 3D Structure Click here
A0A368UGN4 View 3D Structure Click here
A0A368UK14 View 3D Structure Click here
B4FAI3 View 3D Structure Click here
B4FAJ9 View 3D Structure Click here
B4FAT5 View 3D Structure Click here
B6SWF4 View 3D Structure Click here
B9G469 View 3D Structure Click here
B9GCW9 View 3D Structure Click here
C0HF77 View 3D Structure Click here
C0HFN9 View 3D Structure Click here
C0HGM2 View 3D Structure Click here
C0P5D8 View 3D Structure Click here
C0P6H8 View 3D Structure Click here
C0PEI3 View 3D Structure Click here
C0PGC4 View 3D Structure Click here
C0PHQ7 View 3D Structure Click here
C7J6W5 View 3D Structure Click here
F4HPF1 View 3D Structure Click here
F4HSQ2 View 3D Structure Click here
F4HYR6 View 3D Structure Click here
F4IG09 View 3D Structure Click here
F4JA91 View 3D Structure Click here
F4JJH4 View 3D Structure Click here
F4JJH5 View 3D Structure Click here
F4JJL8 View 3D Structure Click here
F4JXC5 View 3D Structure Click here
F4KEL0 View 3D Structure Click here
F4KGD4 View 3D Structure Click here
I1J896 View 3D Structure Click here
I1J8A9 View 3D Structure Click here
I1JA10 View 3D Structure Click here
I1JDQ1 View 3D Structure Click here
I1JPZ7 View 3D Structure Click here
I1JSE5 View 3D Structure Click here
I1JT08 View 3D Structure Click here
I1K0F9 View 3D Structure Click here
I1K2B5 View 3D Structure Click here
I1K3S7 View 3D Structure Click here
I1K4C3 View 3D Structure Click here
I1K850 View 3D Structure Click here
I1KHC9 View 3D Structure Click here
I1KHH8 View 3D Structure Click here
I1KHQ1 View 3D Structure Click here
I1KIJ4 View 3D Structure Click here
I1KNH1 View 3D Structure Click here
I1KST3 View 3D Structure Click here
I1L1D2 View 3D Structure Click here
I1L1Q6 View 3D Structure Click here
I1L210 View 3D Structure Click here
I1L634 View 3D Structure Click here
I1LAF3 View 3D Structure Click here
I1LBU9 View 3D Structure Click here
I1LDX7 View 3D Structure Click here
I1LGJ5 View 3D Structure Click here
I1LH87 View 3D Structure Click here
I1LJ14 View 3D Structure Click here
I1LKT4 View 3D Structure Click here
I1LPR5 View 3D Structure Click here
I1LY64 View 3D Structure Click here
I1M0I4 View 3D Structure Click here
I1M1L8 View 3D Structure Click here
I1M8S3 View 3D Structure Click here
I1MHR3 View 3D Structure Click here
I1MK60 View 3D Structure Click here
I1MKD2 View 3D Structure Click here
I1MMW0 View 3D Structure Click here
I1MQ62 View 3D Structure Click here
I1MUP9 View 3D Structure Click here
I1MUT1 View 3D Structure Click here
I1MXJ1 View 3D Structure Click here
I1N3W4 View 3D Structure Click here
I1N462 View 3D Structure Click here
I1N9V7 View 3D Structure Click here
I1NCT4 View 3D Structure Click here
I1NGM4 View 3D Structure Click here
I1NIK1 View 3D Structure Click here
K7K540 View 3D Structure Click here
K7KCA4 View 3D Structure Click here
K7KH84 View 3D Structure Click here
K7KJF6 View 3D Structure Click here
K7KPC3 View 3D Structure Click here
K7KQC7 View 3D Structure Click here
K7KSL4 View 3D Structure Click here
K7L411 View 3D Structure Click here
K7LNR4 View 3D Structure Click here
K7LP60 View 3D Structure Click here
K7LRM8 View 3D Structure Click here
K7LWT5 View 3D Structure Click here
K7M4Y8 View 3D Structure Click here
K7M586 View 3D Structure Click here
K7M592 View 3D Structure Click here
K7M593 View 3D Structure Click here
K7MAF1 View 3D Structure Click here
K7MBT7 View 3D Structure Click here
K7MD65 View 3D Structure Click here
K7MJ92 View 3D Structure Click here
K7MK51 View 3D Structure Click here
K7TN98 View 3D Structure Click here
K7TRW1 View 3D Structure Click here
K7U275 View 3D Structure Click here
K7U9N2 View 3D Structure Click here
K7UTX5 View 3D Structure Click here
K7VAR5 View 3D Structure Click here
K7VJE6 View 3D Structure Click here
O23357 View 3D Structure Click here
O49607 View 3D Structure Click here
O64495 View 3D Structure Click here
O65351 View 3D Structure Click here
Q0D3H9 View 3D Structure Click here
Q0DB15 View 3D Structure Click here
Q0DIR5 View 3D Structure Click here
Q0E251 View 3D Structure Click here
Q0JBB7 View 3D Structure Click here
Q0JD53 View 3D Structure Click here
Q0JF91 View 3D Structure Click here
Q0JF92 View 3D Structure Click here
Q0JIK5 View 3D Structure Click here
Q0JJP0 View 3D Structure Click here
Q10P89 View 3D Structure Click here
Q10RX3 View 3D Structure Click here
Q1PDX5 View 3D Structure Click here
Q1PFP8 View 3D Structure Click here
Q5ZBR8 View 3D Structure Click here
Q69P78 View 3D Structure Click here
Q6EPJ5 View 3D Structure Click here
Q6ESH8 View 3D Structure Click here
Q6H733 View 3D Structure Click here
Q6I5K9 View 3D Structure Click here
Q6K7F4 View 3D Structure Click here
Q6K7F9 View 3D Structure Click here
Q6K7G5 View 3D Structure Click here
Q6WNU4 View 3D Structure Click here
Q6ZL89 View 3D Structure Click here
Q75I27 View 3D Structure Click here
Q7XPR8 View 3D Structure Click here
Q7XPR9 View 3D Structure Click here
Q7XSC3 View 3D Structure Click here
Q7XT44 View 3D Structure Click here
Q84WS0 View 3D Structure Click here
Q8GUK4 View 3D Structure Click here
Q8GWX9 View 3D Structure Click here
Q8H047 View 3D Structure Click here
Q8L7D2 View 3D Structure Click here
Q8L7I2 View 3D Structure Click here
Q8RVA0 View 3D Structure Click here
Q8RVC2 View 3D Structure Click here
Q8S1N3 View 3D Structure Click here
Q94EF5 View 3D Structure Click here
Q94H95 View 3D Structure Click here
Q9C7U8 View 3D Structure Click here
Q9FGU3 View 3D Structure Click here
Q9FHA4 View 3D Structure Click here
Q9FI12 View 3D Structure Click here
Q9FIF8 View 3D Structure Click here
Q9FIG1 View 3D Structure Click here
Q9FIG2 View 3D Structure Click here
Q9FIG3 View 3D Structure Click here
Q9FIM5 View 3D Structure Click here
Q9FIM6 View 3D Structure Click here
Q9FIM8 View 3D Structure Click here
Q9FK76 View 3D Structure Click here
Q9FLI4 View 3D Structure Click here
Q9LDM8 View 3D Structure Click here
Q9LJ20 View 3D Structure Click here
Q9LLL8 View 3D Structure Click here
Q9LNU1 View 3D Structure Click here
Q9LUM3 View 3D Structure Click here
Q9LVJ1 View 3D Structure Click here
Q9LZS6 View 3D Structure Click here
Q9MAP4 View 3D Structure Click here
Q9MAP5 View 3D Structure Click here
Q9MAP7 View 3D Structure Click here
Q9SA75 View 3D Structure Click here
Q9STF7 View 3D Structure Click here
Q9STQ2 View 3D Structure Click here
Q9SUN6 View 3D Structure Click here
Q9SVT4 View 3D Structure Click here
Q9SZY2 View 3D Structure Click here
Q9SZY3 View 3D Structure Click here
Q9ZSB0 View 3D Structure Click here
Q9ZSB1 View 3D Structure Click here
Q9ZSP5 View 3D Structure Click here
Q9ZUF6 View 3D Structure Click here