Summary: PUA-like domain
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PUA-like domain Provide feedback
This PUA-like domain is found at the N-terminus of SAM-dependent methyltransferases .
Sun W, Xu X, Pavlova M, Edwards AM, Joachimiak A, Savchenko A, Christendat D;, Protein Sci. 2005;14:3121-3128.: The crystal structure of a novel SAM-dependent methyltransferase PH1915 from Pyrococcus horikoshii. PUBMED:16260766 EPMC:16260766
Internal database links
|Similarity to PfamA using HHSearch:||PUA TruB-C_2|
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
- the number of residues in the sequence
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This clan consists of the RNA binding PUA domain and ASCH domain. It also contains uncharacterised protein families.
The clan contains the following 18 members:ASCH DUF2584 DUF365 DUF3850 EVE LON_substr_bdg Methyltranf_PUA PrgU PUA PUA_2 PUA_3 RE_AspBHI_N SAD_SRA SRA TruB-C_2 TruB_C UPF0113 YTH
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the UniProtKB sequence database using the family HMM
You can see the alignments as HTML or in three different sequence viewers:
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
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Curation and family details
|Number in seed:||143|
|Number in full:||3908|
|Average length of the domain:||64.00 aa|
|Average identity of full alignment:||29 %|
|Average coverage of the sequence by the domain:||15.68 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||3|
|Download:||download the raw HMM for this family|
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The tree shows the occurrence of this domain across different species. More...
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the PUA_3 domain has been found. There are 20 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.
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