# STOCKHOLM 1.0
#=GF ID Transp_inhibit
#=GF AC PF18791.2
#=GF DE Transport inhibitor response 1 protein domain
#=GF AU Piovesan D;0000-0001-8210-2390
#=GF GA 33.0 29.0
#=GF NC 32.4 28.8
#=GF TC 33.1 29.5
#=GF SE RepeatsDB
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 18391211
#=GF RT Small-molecule agonists and antagonists of F-box
#=GF RT protein-substrate interactions in auxin perception and
#=GF RT signaling.
#=GF RA Hayashi K, Tan X, Zheng N, Hatate T, Kimura Y, Kepinski S,
#=GF RA Nozaki H;
#=GF RL Proc Natl Acad Sci U S A. 2008;105:5632-5637.
#=GF RN [2]
#=GF RM 20927106
#=GF RT Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ
#=GF RT co-receptor.
#=GF RA Sheard LB, Tan X, Mao H, Withers J, Ben-Nissan G, Hinds TR,
#=GF RA Kobayashi Y, Hsu FF, Sharon M, Browse J, He SY, Rizo J, Howe GA,
#=GF RA Zheng N;
#=GF RL Nature. 2010;468:400-405.
#=GF DR INTERPRO; IPR041101;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC The F-box protein Transport inhibitor response 1 (TIR1) is a
#=GF CC receptor for auxin, triggering an auxin-enhanced and
#=GF CC ubiquitin-mediated  degradation of substrates [1]. The targets
#=GF CC are recruited via  interaction with the leucine-rich repeat
#=GF CC region of the protein. This  Pfam entry represents a specific
#=GF CC unit of the LRR region, including  an insertion of one short
#=GF CC alpha-helix in the loop between the  beta-strand and the
#=GF CC following helix. It shares some sequence homology with a unit
#=GF CC with similar structure of Coronatine-insensitive protein  1 [2].
#=GF SQ 56
A0A178VA54.1/66-112    PKVRSVELKGKPHFADFNLVPDG..WGGYVYPWIEAMSSSYTWLEEIRL
Q570C0.2/66-112        PKVRSVELKGKPHFADFNLVPDG..WGGYVYPWIEAMSSSYTWLEEIRL
A0A2K3MQ55.1/65-111    PKLRSITLKGKPHFADFNLVPEG..WGGYVCPWIKAMAVAYPCLEEIKL
A0A2K3NZP2.1/62-108    PELRSITLKGKPHFADFNLVPDG..WGGYVYTWIEAMAVSVPLLEEIRL
A0A178UB83.1/111-157   KRVRSLVLKGKPRFADFNLMPPD..WGANFAPWVSTMAQAYPCLEKVDL
Q9LTX2.1/111-157       KRVRSLVLKGKPRFADFNLMPPD..WGANFAPWVSTMAQAYPCLEKVDL
A0A178UVM5.1/111-157   KRVRSLVLKGKPRFADFNLMPPN..WGAQFSPWVAATAKAYPWLEKVHL
Q8RWQ8.1/111-157       KRVRSLVLKGKPRFADFNLMPPN..WGAQFSPWVAATAKAYPWLEKVHL
Q7XVM8.1/61-107        PNVRALTVKGKPHFADFNLVPPD..WGGYAGPWIEAAARGCHGLEELRM
A0A178WFK2.1/61-107    PCLKSLTLKGKPHFADFNLVPHE..WGGFVHPWIEALARSRVGLEELRL
Q9LPW7.1/61-107        PCLKSLTLKGKPHFADFNLVPHE..WGGFVHPWIEALARSRVGLEELRL
A0A2K3PGW7.1/64-110    PNIRSVTLKGKPRFSDFNLVPAN..WGADIHPWLVVFAEKYPFLEELKL
A0A2K3P4H9.1/70-116    PHLESLKLKGKPRAAMFNLIPED..WGGHVTPWIKEISQYFDCLKNLHF
A0A178UXT3.1/62-108    PEMRSLTLKGKPHFADYNLVPDG..WGGYAWPWIEAMAAKSSSLEEIRM
Q9ZR12.1/62-108        PEMRSLTLKGKPHFADYNLVPDG..WGGYAWPWIEAMAAKSSSLEEIRM
A0A2K3MYF3.1/61-107    PDLKSLTLKGKPHFADFSLVPHG..WGGFVYPWIEALAKSKVGLEELRL
A0A178VGF7.1/61-107    PCLKSLTLKGKPHFADFNLVPHE..WGGFVLPWIEALARSRVGLEELRL
Q9LW29.1/61-107        PCLKSLTLKGKPHFADFNLVPHE..WGGFVLPWIEALARSRVGLEELRL
D8SDE6.1/76-122        PRLKSMTLKGKPRFADFSLVPPN..WGAFFHPWMPVIVESYPWLEALRL
D8RF91.1/81-127        PRLKSMTLKGKPRFADFSLVPPN..WGAFFHPWMPVIVESYPWLEALRL
A0A178VMU2.1/73-119    PNLRSLKLKGKPRAAMFNLIPEN..WGGYVTPWVTEISNNLRQLKSVHF
O04197.1/73-119        PNLRSLKLKGKPRAAMFNLIPEN..WGGYVTPWVTEISNNLRQLKSVHF
A0A2K3MTJ3.1/109-154   -RIKSVTVKGKPRFADFDLMPVD..WGAHFTPWATSLSQAYPWLQKLHL
D8R5Z3.1/62-108        PKVRSLTLKGKPRFADFNLLPPH..WGAYLLPWIVTFAHASLPLEELRL
D8SG63.1/62-108        PKVRSLTLKGKPRFADFNLLPPH..WGAYLLPWIVTFAHASLPLEELRL
Q6K8E2.1/125-170       -GVRAVVLKGKPRFADFSLVPYG..WGAYVSPWVAALGPAYPHLERICL
Q60EH4.1/80-126        PRLESLAVKGKPRAAMYGLIPED..WGAYARPWVAELAAPLECLKALHL
A0A2K1IVK2.1/63-109    PKLVSLEMKGRPRFTDFGLVPQN..WGGFIQPWIQVMAEYYPGLEGLKL
A0A2K1KTR5.1/88-134    PNIEKFKIKGKPRAVEFNLLVDD..WGGYASAWVEEIVRAYPRLHTLHF
Q6Y9P5.1/78-124        PRLESLSLKGKPRAAMYGLIPDD..WGAYAAPWIDELAAPLECLKALHL
A0A2K3PAC0.1/75-121    PHLESLKLKGKPRAAMFNLIPEN..WGGFVTPWVREIEKYFDCLKSLHF
Q84QA7.1/75-121        PCLESLKLKAKPRAAMFNLIPED..WGGSASPWIRQLSASFHFLKALHL
A0A2K1II60.1/63-109    PKLVALEMKGRPRFTDFGLVPQN..WGAFIQPWIEAMAEYYPGLEELKL
A9TAY1.1/62-108        PKLTSLEMKGRPRFTDFGLVPSN..WGAFIQPWIEALAEHYAGLECLRL
A0A2K3PI18.1/83-128    -RILSVTIKGKPRLADFDMLPAD..WGAHFSQWLTAFSTAYPWLEKVHL
D8QPC7.1/89-135        PNLRSLKLKAKPRAYEFDLLPHN..WGGHVHPWLENIGPAYPQLSALHL
A9SYG2.1/62-108        PKLTSLAMKGRPRFTDFGLVPSS..WGAFIQPWIEALADHYNGLECLRL
D8SL48.1/89-135        PNLRSLKLKAKPRAYEFDLLPHN..WGGHVHPWLENIGPAYPQLSALHL
A0A2K1JBJ4.1/73-119    KRLEGLKLKGKPRAAEYDLLVPD..WGGYAEPWIRDLGRAYTSLQTLQL
Q0DKP3.2/77-123        PSVRAAEVKGKPHFADFGLVPPA..WGAAAAPWIAAAADGWPLLEELSF
A0A2K1K2P6.1/79-124    -GLEGIKLKGKPRAAEYNLVRSD..WGGYGEPWLKVLGRQYADLHILQL
A0A0P0Y299.1/1070-1115 -GLRSITLKGRPCFADSTLVPKG..WGAYASPWVAALGPAYPHLKCIFL
A0A2K1J333.1/74-120    KRLEGVKIKGKPRAEEYGLLVPN..WGGYAEPWIRELGRVYRGLQTLLL
A0A2K1IJZ0.1/91-137    PNLEKIKIKGKPRAYEFGLLVES..WGAHAGPWIEEIASVYPNLEGLAL
D8R3V6.1/79-115        -QLRALKIKGKPRASDFGLIPVD..WGGYGGPWIAALALA---------
D8RAG1.1/79-115        -QLRALKIKGKPRASDFGLIPVD..WGGYGGPWIAALALA---------
D8SYC3.1/58-102        --LASVTIKGRPRIYDWGLLGDD..WGGTADAWIRVLVACCPSLAAIHL
A0A2K1ITY6.1/95-139    -SLQKIKIKGKPRAYEFGLLVER..WGGHAGPWIGEMSRAYPELLGLS-
D8T758.1/77-121        --LASVTIKGRPRIYDWGLLGDD..WGGAADTWIRVLVACCPSLAAIHL
D8R8S9.1/62-98         -NIQALKIKGKPRVSEFGMVVKD..WGAYCEPWIQELVSQ---------
D8QQ49.1/59-95         -NIQALKIKGKPRVSEFGMVVKD..WGAYCEPWIQELVSQ---------
D8RZD2.1/76-118        PSVRSITIKGNPRLVDFDILPRD..WAGHAGPWIAAI-KAHPQLNR---
D8TEP2.1/76-118        PSVRSITIKGNPRLVDFDILPRD..WAGHAGPWIAAI-KAHPQLNR---
A9RJB8.1/161-208       PNAKSITIKGKPRIVDFSLIPHAevWGAYATPWVDLLKEHYRPIRHLK-
Q2R3K5.1/61-102        PGLRSLSVKGRPRF-----VPAG..WGAAARPWVAACVAACPGLEELRL
A0A2K1J1C2.1/81-116    --AWSITIKGKPRIVDFALIPHAevWGAYATPWMEILV-----------
//