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206  structures 1197  species 0  interactions 7007  sequences 112  architectures

Family: Terpene_syn_C_2 (PF19086)

Summary: Terpene synthase family 2, C-terminal metal binding

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This is the Wikipedia entry entitled "Terpene synthase C terminal domain". More...

Terpene synthase C terminal domain Edit Wikipedia article

PDB 5eau EBI.jpg
5-epi-aristolochene synthase from nicotiana tabacum
Symbol Terpene_synth_C
Pfam PF03936
InterPro IPR005630
SCOP 5eau

In molecular biology, this protein domain belongs to the terpene synthase family (TPS). Its role is to synthesize terpenes which are part of primary metabolism, such as sterols and carotene and also part of the secondary metabolism. This entry will focus on the C terminal domain of the TPS protein.


Terpenes synthases have a role in producing important molecules in metabolism, these molecules are part of a large group called terpenoids . In particular, the C terminal domain catalyzes the cyclization of geranyl diphosphate, orienting and stabilizing multiple reactive carbocation intermediates. Or in simpler terms, the C terminal aids the synthesis of new molecules.


It is thought to have at least two alpha helices.[1]


Sequences containing this protein domain belong to the terpene synthase family. It has been suggested that this gene family be designated tps (for terpene synthase). Sequence comparisons reveal similarities between the monoterpene (C10) synthases, sesquiterpene (C15) synthases and the diterpene (C20) synthases. It has been split into six subgroups on the basis of phylogeny, called Tpsa-Tpsf .[2]

See also

Terpene synthase N terminal domain


  1. ^ Starks CM, Back K, Chappell J, Noel JP (1997). "Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase". Science. 277 (5333): 1815–20. doi:10.1126/science.277.5333.1815. PMID 9295271. 
  2. ^ Bohlmann J, Steele CL, Croteau R (August 1997). "Monoterpene synthases from grand fir (Abies grandis). cDNA isolation, characterization, and functional expression of myrcene synthase, (-)-(4S)-limonene synthase, and (-)-(1S,5S)-pinene synthase". J. Biol. Chem. 272 (35): 21784–92. doi:10.1074/jbc.272.35.21784. PMID 9268308. 
  3. ^ [1], 5-epi- aristolochene synthase, [2] and (+)-delta-cadinene synthase SWISSPROT
  4. ^ "4S-limonene synthase precursor - Mentha spicata (Spearmint)". doi:10.1073/pnas.0700915104. Retrieved 2012-08-02. 
  5. ^ "Ent-copalyl diphosphate synthase, chloroplastic precursor - Pisum sativum (Garden pea)". doi:10.1046/j.1365-313X.1997.11030443.x. Retrieved 2012-08-02. 
  6. ^ "Taxadiene synthase - Taxus brevifolia (Pacific yew)". doi:10.1074/jbc.271.16.9201. Retrieved 2012-08-02. 
  7. ^ "Pinene synthase, chloroplastic precursor - Abies grandis (Grand fir)". Retrieved 2012-08-02. 
  8. ^ "Myrcene synthase, chloroplastic precursor - Abies grandis (Grand fir)". Retrieved 2012-08-02. 
  9. ^ "Ent-kaur-16-ene synthase, chloroplastic precursor - Cucurbita maxima (Pumpkin)". doi:10.1046/j.1365-313X.1996.10020203.x. Retrieved 2012-08-02. 
  10. ^ "Linalool synthase - Clarkia concinna (Red ribbons)". Retrieved 2012-08-02. 
  11. ^ Kawaide H, Imai R, Sassa T, Kamiya Y (August 1997). "Ent-kaurene synthase from the fungus Phaeosphaeria sp. L487. cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase in fungal gibberellin biosynthesis". J. Biol. Chem. 272 (35): 21706–12. doi:10.1074/jbc.272.35.21706. PMID 9268298. 

This article incorporates text from the public domain Pfam and InterPro IPR005630

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Terpene synthase family 2, C-terminal metal binding Provide feedback

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Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Terp_synthase (CL0613), which has the following description:

This superfamily includes a diverse range of terpene synthase enzymes which share an alpha helical core.

The clan contains the following 7 members:

HEPPP_synt_1 polyprenyl_synt SQS_PSY Terpene_syn_C_2 Terpene_synth_C TRI5 UbiA


We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

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This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

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Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

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Seed source: Manual
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Finn RD
Number in seed: 2094
Number in full: 7007
Average length of the domain: 186.00 aa
Average identity of full alignment: 17 %
Average coverage of the sequence by the domain: 46.25 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 23.7 23.7
Trusted cut-off 23.7 23.7
Noise cut-off 23.6 23.6
Model length: 199
Family (HMM) version: 2
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Species distribution

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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Terpene_syn_C_2 domain has been found. There are 206 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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