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2991  structures 1924  species 0  interactions 187300  sequences 6262  architectures

Family: PK_Tyr_Ser-Thr (PF07714)

Summary: Protein tyrosine and serine/threonine kinase

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Tyrosine kinase Edit Wikipedia article

Protein tyrosine kinase
Hck protein tyrosine kinase.png
pdb 2HCK, rendered in PyMOL
Identifiers
SymbolPkinase_Tyr
PfamPF07714
InterProIPR001245
SMARTTyrKc
PROSITEPDOC00629
SCOPe1apm / SUPFAM
OPM superfamily186
OPM protein2k1k
CDDcd00192
Membranome3

A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell. It functions as an "on" or "off" switch in many cellular functions. Tyrosine kinases are a subclass of protein kinase.

The phosphate group is attached to the amino acid tyrosine on the protein. Tyrosine kinases are a subgroup of the larger class of protein kinases that attach phosphate groups to other amino acids (serine and threonine). Phosphorylation of proteins by kinases is an important mechanism in communicating signals within a cell (signal transduction) and regulating cellular activity, such as cell division.

Protein kinases can become mutated, stuck in the "on" position, and cause unregulated growth of the cell, which is a necessary step for the development of cancer. Therefore, kinase inhibitors, such as imatinib, are often effective cancer treatments.

Most tyrosine kinases have an associated protein tyrosine phosphatase, which removes the phosphate group.

Reaction

Protein kinases are a group of enzymes that possess a catalytic subunit that transfers the gamma (terminal) phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side-chain, resulting in a conformational change affecting protein function. The enzymes fall into two broad classes, characterised with respect to substrate specificity: serine/threonine-specific, and tyrosine-specific (the subject of this article).[1]

Function

Kinase is a large family of enzymes that are responsible for catalyzing the transfer of a phosphoryl group from a nucleoside triphosphate donor, such as ATP, to an acceptor molecule.[2] Tyrosine kinases catalyze the phosphorylation of tyrosine residues in proteins.[2] The phosphorylation of tyrosine residues in turn causes a change in the function of the protein that they are contained in.[2]

Phosphorylation at tyrosine residues controls a wide range of properties in proteins such as enzyme activity, subcellular localization, and interaction between molecules.[3] Furthermore, tyrosine kinases function in many signal transduction cascades wherein extracellular signals are transmitted through the cell membrane to the cytoplasm and often to the nucleus, where gene expression may be modified.[3] Finally mutations can cause some tyrosine kinases to become constitutively active, a nonstop functional state that may contribute to initiation or progression of cancer.

Tyrosine kinases function in a variety of processes, pathways, and actions, and are responsible for key events in the body. The receptor tyrosine kinases function in transmembrane signaling, whereas tyrosine kinases within the cell function in signal transduction to the nucleus.[4] Tyrosine kinase activity in the nucleus involves cell-cycle control and properties of transcription factors.[3] In this way, in fact, tyrosine kinase activity is involved in mitogenesis, or the induction of mitosis in a cell; proteins in the cytosol and proteins in the nucleus are phosphorylated at tyrosine residues during this process.[3] Cellular growth and reproduction may rely to some degree on tyrosine kinase. Tyrosine kinase function has been observed in the nuclear matrix, which comprises not the chromatin but rather the nuclear envelope and a “fibrous web” that serves to physically stabilize DNA.[3] To be specific, Lyn, a type of kinase in the Src family that was identified in the nuclear matrix, appears to control the cell cycle. Src family tyrosine kinases are closely related but demonstrate a wide variety of functionality. Roles or expressions of Src family tyrosine kinases vary significantly according to cell type, as well as during cell growth and differentiation.[3] Lyn and Src family tyrosine kinases in general have been known to function in signal transduction pathways.[3] There is evidence that Lyn is localized at the cell membrane; Lyn is associated both physically and functionally with a variety of receptor molecules.[3]

Fibroblasts – a type of cell that synthesizes the extracellular matrix and collagen and is involved in wound healing – that have been transformed by the polyomavirus possess higher tyrosine activity in the cellular matrix. Furthermore, tyrosine kinase activity has been determined to be correlated to cellular transformation.[3] It has also been demonstrated that phosphorylation of a middle-T antigen on tyrosine is also associated with cell transformation, a change that is similar to cellular growth or reproduction.[3]

The transmission of mechanical force and regulatory signals are quite fundamental in the normal survival of a living organism. Protein tyrosine kinase plays a role in this task, too. A protein tyrosine kinase called pp125 is likely at hand in the influence of cellular focal adhesions, as indicated by an immunofluorescent localization of the said kinase. Focal adhesions are macromolecular structures that function in the transmission of mechanical force and regulatory signals.[5] Among the scientific community, pp125 is also referred to as FAK (focal adhesion kinase), due to its aforementioned presence in cellular focal adhesions. The protein tyrosine kinase pp125 is one of the major phosphotyrosine–containing proteins in unaffected (untransformed) avian and rodent fibroblast cells (fibroblast cells are explained above in some detail).[5] Fibroblasts are a cell type responsible for wound healing and cell structure in animals, among a number of other relatively minor but important jobs that take place often or occasionally. The sequence and structure of pp125, when compared to National Biomedical Research Foundation and GenBank data bases,[5] may be quite unique, meaning that it could be a new member of the protein tyrosine kinase family. This protein tyrosine kinase is up to about 70% unique compared to some other protein tyrosine kinases, a figure that is unlike those between actual members of an established protein tyrosine kinase family.[5] Also, the amino acid sequence that was observed indirectly signifies that it is associated with the cytoplasm, dubbing it one in a large group of cytoplasmic protein tyrosine kinases.[5] It was discovered when monoclonal antibodies were observed to recognize it.[5] Monoclonal antibodies, from chicken embryo cells transformed by pp60v-src, recognize seven different phosphotyrosine-containing proteins.[5] One of these monoclonal antibodies, named 2A7, recognizes pp125, support for the idea that pp125 is, in fact, a protein tyrosine kinase.[5]

Cellular proliferation, as explained in some detail above, may rely in some part on tyrosine kinase.[3] Tyrosine kinase function has been observed in the nuclear matrix. Lyn, the type of kinase that was the first to be discovered in the nuclear matrix, is part of Src family of tyrosine kinases, which can be contained in the nucleus of differentiating, calcium-provoked kertinocytes. Lyn, in the nuclear matrix, among the nuclear envelope and the “fibrous web” that physically stabilizes DNA, was found functioning in association with the matrix. Also, it appeared to be conditional to cell cycle.[3] The contribution of the Lyn protein to the total tyrosine kinase activity within the nuclear matrix is unknown, however; because the Lyn was extracted only partially, an accurate measurement of its activity could not be managed.[3] Indications, as such, are that, according to Vegesna et al. (1996), Lyn polypeptides are associated with tyrosine kinase activity in the nuclear matrix. The extracted Lyn was enzymatically active, offering support for this notion.

Yet another possible and probable role of protein tyrosine kinase is that in the event of circulatory failure and organ dysfunction caused by endotoxin in rats, where the effects of inhibitors tyrphostin and genistein are involved with protein tyrosine kinase.[4] Signals in the surroundings received by receptors in the membranes of cells are transmitted into the cell cytoplasm. Transmembrane signaling due to receptor tyrosine kinases, according to Bae et al. (2009), relies heavily on interactions, for example, mediated by the SH2 protein domain; it has been determined via experimentation that the SH2 protein domain selectivity is functional in mediating cellular processes involving tyrosine kinase. Receptor tyrosine kinases may, by this method, influence growth factor receptor signaling. This is one of the more fundamental cellular communication functions metazoans.[6]

Regulation

Major changes are sometimes induced when the tyrosine kinase enzyme is affected by other factors. One of the factors is a molecule that is bound reversibly by a protein, called a ligand. A number of receptor tyrosine kinases, though certainly not all, do not perform protein-kinase activity until they are occupied, or activated, by one of these ligands.[2] Although more research indicates that receptors remain active within endosomes, it was once thought that endocytosis caused by ligands was the event responsible for the process in which receptors are inactivated. Activated receptor tyrosine kinase receptors are internalized (recycled back into the system) in short time and are ultimately delivered to lysosomes, where they become work-adjacent to the catabolic acid hydrolases that partake in digestion. Internalized signaling complexes are involved in different roles in different receptor tyrosine kinase systems, the specifics of which were researched.[7] In addition, ligands participate in reversible binding, with inhibitors binding non-covalently (inhibition of different types are effected depending on whether these inhibitors bind the enzyme, the enzyme-substrate complex, or both). Multivalency, which is an attribute that bears particular interest to some people involved in related scientific research, is a phenomenon characterized by the concurrent binding of several ligands positioned on one unit to several coinciding receptors on another.[8] In any case, the binding of the ligand to its partner is apparent owing to the effects that it can have on the functionality of many proteins.[2] Ligand-activated receptor tyrosine kinases, as they are sometimes referred to, demonstrate a unique attribute. Once a tyrosine receptor kinase is bonded to its ligand, it is able to bind to tyrosine kinase residing in the cytosol of the cell.[2]

Erythrocytes as an example

An example of this trigger-system in action is the process by which the formation of erythrocytes is regulated. Mammals possess this system, which begins in the kidneys where the developmental signal is manufactured.[2] The developmental signal, also called a cytokine, is erythropoietin in this case. (Cytokines are key regulators of hematopoietic cell proliferation and differentiation.) Erythropoietin's activity is initiated when hematopoietic cytokine receptors become activated.[9] In erythrocyte regulation, erythropoietin is a protein containing 165 amino acids that plays a role in activating the cytoplasmic protein kinase JAK.[2] The results of some newer research have also indicated that the aforementioned cytokine receptors function with members of the JAK tyrosine kinase family. The cytokine receptors activate the JAK kinases. This then results in the phosphorylation of several signaling proteins located in the cell membrane. This subsequently affects both the stimulation of ligand-mediated receptors and intracellular signaling pathway activation.[9] Substrates for JAK kinases mediate some gene responses and more.[9] The process is also responsible for mediating the production of blood cells.[2] In this case, erythropoietin binds to the corresponding plasma membrane receptor, dimerizing the receptor.[2] The dimer is responsible for activating the kinase JAK via binding.[2] Tyrosine residues located in the cytoplasmic domain of the erythropoietin receptor are consequently phosphorylated by the activated protein kinase JAK.[2] Overall, this is also how a receptor tyrosine kinase might be activated by a ligand to regulate erythrocyte formation.

Other examples

Additional instances of factor-influenced protein tyrosine kinase activity, similar to this one, exist. An adapter protein such as Grb2 will bind to phosphate-tyrosine residues under the influence of receptor protein kinases. This mechanism is an ordinary one that provokes protein-protein interactions.[2]

Furthermore, to illustrate an extra circumstance, insulin-associated factors have been determined to influence tyrosine kinase. Insulin receptor substrates are molecules that function in signaling by regulating the effects of insulin.[2] Many receptor enzymes have closely related structure and receptor tyrosine kinase activity, and it is said by Lehninger (2008) that the foundational or prototypical receptor enzyme, is insulin. Insulin receptor substrates IRS2 and IRS3 each have unique characteristic tissue function and distribution that serves to enhance signaling capabilities in pathways that are initiated by receptor tyrosine kinases.[2] Activated IRS-1 molecules enhance the signal created by insulin.[2] The insulin receptor system, in contrast, appears to diminish the efficacy of endosomal signaling.[7]

The epidermal growth factor receptor system, as such, has been used as an intermediate example.[7] Some signals are produced from the actual cell surface in this case but other signals seem to emanate from within the endosomes. This variety of function may be a means to create ligand-specific signals.[7] This supports the notion that trafficking, a term for the modification of proteins subsequent to mRNA translation, may be vital to the function of receptor signaling.

Structure

Included in a number of the structural features that can be recognized in all protein tyrosine kinases are an ATP binding site, three residues that are thought to be associated with the function of the third phosphate group (often called the gamma-phosphate group) of an ATP molecule bound to the enzyme, and a possible catalytic site of the enzyme that is an amino acid.[5] Also very common among protein tyrosine kinases are two peptide sequences.[5]

There are over 100 3D structures of tyrosine kinases available at the Protein Data Bank. An example is PDB: 1IRK​, the crystal structure of the tyrosine kinase domain of the human insulin receptor.

Families

The tyrosine kinases are divided into two main families:

More than 90 protein tyrosine kinases (PTKs) have been found in the human genome. They are divided into two classes, receptor and non-receptor tyrosine kinases.

Receptor

By 2004, 58 receptor tyrosine kinases (RTKs) were known, grouped into 20 subfamilies. They play pivotal roles in diverse cellular activities including growth (by signaling neurotrophins), differentiation, metabolism, adhesion, motility, death.[10] RTKs are composed of an extracellular domain, which is able to bind a specific ligand, a transmembrane domain, and an intracellular catalytic domain, which is able to bind and phosphorylate selected substrates. Binding of a ligand to the extracellular region causes a series of structural rearrangements in the RTK that lead to its enzymatic activation. In particular, movement of some parts of the kinase domain gives free access to adenosine triphosphate (ATP) and the substrate to the active site. This triggers a cascade of events through phosphorylation of intracellular proteins that ultimately transmit ("transduce") the extracellular signal to the nucleus, causing changes in gene expression. Many RTKs are involved in oncogenesis, either by gene mutation, or chromosome translocation,[11] or simply by over-expression. In every case, the result is a hyper-active kinase, that confers an aberrant, ligand-independent, non-regulated growth stimulus to the cancer cells.

Cytoplasmic/non-receptor

In humans, there are 32 cytoplasmic protein tyrosine kinases (EC 2.7.10.2).

The first non-receptor tyrosine kinase identified was the v-src oncogenic protein. Most animal cells contain one or more members of the Src family of tyrosine kinases. A chicken sarcoma virus was found to carry mutated versions of the normal cellular Src gene.[citation needed] The mutated v-src gene has lost the normal built-in inhibition of enzyme activity that is characteristic of cellular SRC (c-src) genes. SRC family members have been found to regulate many cellular processes. For example, the T-cell antigen receptor leads to intracellular signalling by activation of Lck and Fyn, two proteins that are structurally similar to Src.[citation needed]

Clinical significance

Tyrosine kinases are particularly important today because of their implications in the treatment of cancer. A mutation that causes certain tyrosine kinases to be constitutively active has been associated with several cancers. Imatinib (brand names Gleevec and Glivec) is a drug able to bind the catalytic cleft of these tyrosine kinases, inhibiting its activity.[12]

Tyrosine kinase activity is also significantly involved in other events that are sometimes considered highly unfavorable. For instance, enhanced activity of the enzyme has been implicated in the derangement of the function of certain systems, such as cell division. Also included are numerous diseases related to local inflammation such as atherosclerosis and psoriasis, or systemic inflammation such as sepsis and septic shock.[4] A number of viruses target tyrosine kinase function during infection. The polyoma virus affects tyrosine kinase activity inside the nuclear matrix.[3] Fibroblasts are cells involved in wound healing and cell structure formation in mammalian cells. When these cells are transformed by the polyoma virus, higher tyrosine activity is observed in the cellular matrix, which is also correlated to cellular proliferation.[3] Another virus that targets tyrosine kinase is the Rous sarcoma virus, a retrovirus that causes sarcoma in chickens. Infected cells display obvious structure modifications and cell growth regulation that is extremely unusual.[5] Protein tyrosine kinases that are encoded by the Rous sarcoma virus cause cellular transformation, and are termed oncoproteins.[5] In addition, tyrosine kinase can sometimes function incorrectly in such a way that leads to non-small cell lung cancer.[13] A common, widespread cancer, non-small cell lung cancer is the cause of death in more people than the total number in breast, colorectal, and prostate cancer together.[13]

Research has shown that protein phosphorylation occurs on residues of tyrosine by both transmembrane receptor- and membrane-associated protein tyrosine kinases in normal cells.[5] Phosphorylation plays a significant role in cellular signalling that regulates the number and variety of growth factors.[5] This is evidenced by the observation that cells affected by the Rous sarcoma virus display obvious structural modifications and a total lack of normal cell growth regulation.[5] Rous sarcoma virus-encoded oncoproteins are protein tyrosine kinases that are the cause of, and are required for, this cellular transformation.[5] Tyrosine phosphorylation activity also increases or decreases in conjunction with changes in cell composition and growth regulation.[5] In this way, a certain transformation exhibited by cells is dependent on a role that tyrosine kinase demonstrates.[5] Protein tyrosine kinases, have a major role in the activation of lymphocytes.[5] In addition, they are functional in mediating communication pathways in cell types such as adrenal chromaffin, platelets, and neural cells.[5]

A tyrosine kinase can become an unregulated enzyme within an organism due to influences discussed, such as mutations and more. This behavior causes havoc; essential processes become disorganized. Systems on which the organism relies malfunction, resulting often in cancers. Preventing this type of circumstance is highly desirable. Much research has already noted the significant effect that inhibitors of the radically functioning protein tyrosine kinase enzymes have on related ailments.[citation needed] (See Tyrosine-kinase inhibitor )

Non-small cell lung cancer

Cancer’s response to an inhibitor of tyrosine kinase was assessed in a clinical trial.[13] In this case, Gefitinib is the inhibitor of tyrosine kinase. Incorrect tyrosine kinase function can lead to non-small cell lung cancer.[14] Gefitinib is a tyrosine kinase inhibitor that targets the epidermal growth factor receptor, inducing favorable outcomes in patients with non-small cell lung cancers. A common, widespread cancer, non-small cell lung cancer is the cause of death in more people than breast, colorectal, and prostate cancer together.[13] This is strong motivation to perform research on tyrosine kinase inhibitors as potential targets in cancer treatment. Gefitinib, functioning as an epidermal growth factor receptor tyrosine kinase inhibitor, improved symptoms related to non-small cell lung cancer and resulted in radiographic tumor regressions.[13] This is an example of the efficacy of such an inhibitor. The process of inhibition shows how the cancer sustains. Mutations in the epidermal growth factor receptor activate signalling pathways that promote cell survival. Non-small cell lung cancer cells become dependent on these survival signals. Gefitinib’s inhibition of the survival signals may be a contributing factor to its efficacy as a drug for non-small cell cancer treatment.[14]

Gefitinib is well endured by humans, and treatment resulted in a symptom improvement rate of 43% (with 95% confidence in a 33%–53% interval) for patients that received 250 mg of Gefitinib and 35% (with 95% confidence in a 26%–45% interval) for those that received 500 mg.[13] In the trial, epidermal growth factor receptor showed a rapid response to the inhibitor, as demonstrated by the improvement of the cancer symptoms. In each group, improvements were noted after a single week of epidermal growth factor receptor tyrosine kinase inhibitor treatment.[13] Gefitinib application once per day caused “rapid” symptom improvement and tumor regressions in non-small cell lung cancer patients.[13] In the field of medical research, this is an especially significant example of the use of an inhibitor to treat tyrosine kinase-associated cancer. Chemotherapy, surgery, and radiotherapy were the only major options available prior to the discoveries made in this trial. The side-effects of Gefitinib oral treatment once per day were considered significant. Diarrhea was reported in 57% of patients in the 250 mg group and in 75% of the 500 mg group.[13] One patient had diarrhea more severe than Grade 2, with up to six bowel movements in only one day.[13] Also, a death occurred possibly due to epidermal growth factor receptor tyrosine kinase inhibitor treatment; however, the correlation is not exactly clear.[13] In addition, skin toxicity was observed in 62% of patients in the 250 mg group. Nevertheless, the side-effects of Gefitinib were only “generally mild, manageable, noncumulative, and reversible.”[13] Unfortunately, ceasing to take the inhibitor may be the only reversal strategy of the unfavorable symptoms.[13] Gefitinib still represents a reasonably safe and effective treatment compared to other cancer therapies.

Furthermore, epidermal growth factor receptor plays a crucial role in tumorigenesis, which is the production of a new tumor.[15] By 2010 Two monoclonal antibodies and another small-molecule tyrosine kinase inhibitor called Erlotinib had also been developed to treat cancer.[15]

July 12, 2013 FDA approved afatinib "multiple recepptor, irreversible TKI" for the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have epidermal growth factor receptor (EGFR) mutation

Chronic myeloid leukemia

BCR-ABL is a constitutively activated tyrosine kinase that is associated with chronic myeloid leukemia. It is formed from a fusion gene when pieces of chromosomes 9 and 22 break off and trade places. The ABL gene from chromosome 9 joins to the BCR gene on chromosome 22, to form the BCR-ABL fusion gene.[16] Tyrosine kinase activity is crucial for the transformation of BCR-ABL. Therefore, inhibiting it improves cancer symptoms. Among currently available inhibitors to treat CML are imatinib, dasatinib, nilotinib, bosutinib and ponatinib.

Gastrointestinal stromal tumors

Gastrointestinal stromal tumors (GIST) are known to withstand cancer chemotherapy treatment and do not respond to any kind of therapy (in 2001) in advanced cases. However, tyrosine kinase inhibitor STI571 (imatinib) is effective in the treatment of patients with metastatic gastrointestinal stromal tumors.[17] Gastrointestinal stromal tumors consist of a cluster of mesenchymal neoplasms that are formed from precursors to cells that make up the connective-tissue in the gastrointestinal tract.[17] Most of these tumors are found in the stomach, though they can also be located in the small intestine or elsewhere in the intestinal tract. The cells of these tumors have a growth factor receptor associated with tyrosine kinase activity.[17] This growth factor receptor is called c-kit and is produced by a proto-oncogene (c-kit). Mutation of c-kit causes the constitutive activity of tyrosine kinase, which results in cancerous gastrointestinal stromal tumors. Results of c-kit mutation include unrestricted tyrosine kinase activity and cell proliferation, unregulated phosphorylation of c-kit, and disruption of some communication pathways.[17] Therapy with imatinib can inhibit the non-normal cell signaling mechanisms in gastrointestinal stromal tumors. This results in significant responses in patients and sustained disease control. By 2001 it was no longer doubted that this inhibitor can be effective and safe in humans.[7] In similar manner, protein tyrosine kinase inhibitor STI571 was found to significantly reduce the physical size of tumors; they decreased roughly 65% in size in 4 months of trialing, and continued to diminish. New lesions did not appear, and a number of the liver metastases completely reduced to non-existence. The single patient in the study remained healthy following treatment.[17] There are no effective means of treatment for advanced gastrointestinal stromal tumors, but that STI571 represents an effective treatment in early stage cancer associated with constitutively active c-kit, by inhibiting unfavourable tyrosine kinase activity.[17]

Inhibitors

To reduce enzyme activity, inhibitor molecules bind to enzymes. Reducing enzyme activity can disable a pathogen or correct an incorrectly function system; as such, many enzyme inhibitors are developed to be used as drugs for the general public.

GIST and Imatinib

Gastrointestinal stromal tumors (GIST) are mesenchymal tumors that affect the gastrointestinal tract.[18] Treatment options have been limited.[18] However Imatinib, as an inhibitor to the malfunctioning enzyme, can be effective.[18]

Chronic myelogenous leukemia and nilotinib

If imatinib does not work, patients with advanced chronic myelogenous leukemia can use nilotinib, dasatinib, bosutinib, ponatinib, or another inhibitor to the malfunction enzyme that causes the leukemia.[19] This inhibitor is a highly selective Bcr-Abl tyrosine kinase inhibitor.[19]

Others

Sunitinib is an oral tyrosine kinase inhibitor that acts upon vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), stem cell factor receptor, and colony-stimulating factor-1 receptor (Burstein et al. 2008)

Gefitinib and erlotinib inhibit the tyrosine kinase domain of epidermal growth factor receptor (EGFR), and can be used to treat lung and pancreatic cancer where there is often over-expression of this cell-surface receptor tyrosine kinase.

Kinase inhibitors can also be mediated. Paracrine signalling mediates the response to epidermal growth factor receptor kinase inhibitors. Paracrine activates epidermal growth factor receptor in endothelial cells of the tumor to do this.[20]

Examples

Human proteins containing this domain include:

AATK; ABL; ABL2; ALK; AXL; BLK; BMX; BTK; CSF1R; CSK; DDR1; DDR2; EGFR; EPHA1; EPHA2; EPHA3; EPHA4; EPHA5; EPHA6; EPHA7; EPHA8; EPHA10; EPHB1; EPHB2; EPHB3; EPHB4; EPHB6; ERBB2; ERBB3; ERBB4; FER; FES; FGFR1; FGFR2; FGFR3; FGFR4; FGR; FLT1; FLT3; FLT4; FRK; FYN; GSG2; HCK; IGF1R; ILK; INSR; INSRR; IRAK4; ITK; JAK1; JAK2; JAK3; KDR; KIT; KSR1; LCK; LMTK2; LMTK3; LTK; LYN; MATK; MERTK; MET; MLTK; MST1R; MUSK; NPR1; NTRK1; NTRK2; NTRK3; PDGFRA; PDGFRB; PLK4; PTK2; PTK2B; PTK6; PTK7; RET; ROR1; ROR2; ROS1; RYK; SGK493; SRC; SRMS; STYK1; SYK; TEC; TEK; TEX14; TIE1; TNK1; TNK2; TNNI3K; TXK; TYK2; TYRO3; YES1; ZAP70

See also

References

  1. ^ Hanks SK, Quinn AM, Hunter T (July 1988). "The protein kinase family: conserved features and deduced phylogeny of the catalytic domains". Science. 241 (4861): 42–52. doi:10.1126/science.3291115. PMID 3291115.
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  3. ^ a b c d e f g h i j k l m n o Radha V, Nambirajan S, Swarup G (March 1996). "Association of Lyn tyrosine kinase with the nuclear matrix and cell-cycle-dependent changes in matrix-associated tyrosine kinase activity". European Journal of Biochemistry. 236 (2): 352–9. doi:10.1111/j.1432-1033.1996.00352.x. PMID 8612602.
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  5. ^ a b c d e f g h i j k l m n o p q r s t Schaller MD, Borgman CA, Cobb BS, Vines RR, Reynolds AB, Parsons JT (June 1992). "pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions". Proceedings of the National Academy of Sciences of the United States of America. 89 (11): 5192–6. doi:10.1073/pnas.89.11.5192. PMC 49256. PMID 1594631.
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  18. ^ a b c Blanke CD, Demetri GD, von Mehren M, Heinrich MC, Eisenberg B, Fletcher JA, Corless CL, Fletcher CD, Roberts PJ, Heinz D, Wehre E, Nikolova Z, Joensuu H (February 2008). "Long-term results from a randomized phase II trial of standard- versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT". Journal of Clinical Oncology. 26 (4): 620–5. CiteSeerX 10.1.1.690.6356. doi:10.1200/JCO.2007.13.4403. PMID 18235121.
  19. ^ a b le Coutre P, Ottmann OG, Giles F, Kim DW, Cortes J, Gattermann N, Apperley JF, Larson RA, Abruzzese E, O'Brien SG, Kuliczkowski K, Hochhaus A, Mahon FX, Saglio G, Gobbi M, Kwong YL, Baccarani M, Hughes T, Martinelli G, Radich JP, Zheng M, Shou Y, Kantarjian H (February 2008). "Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is active in patients with imatinib-resistant or -intolerant accelerated-phase chronic myelogenous leukemia". Blood. 111 (4): 1834–9. doi:10.1182/blood-2007-04-083196. PMID 18048643.
  20. ^ Kuwai T, Nakamura T, Sasaki T, Kim SJ, Fan D, Villares GJ, Zigler M, Wang H, Bar-Eli M, Kerbel RS, Fidler IJ (May 2008). "Phosphorylated epidermal growth factor receptor on tumor-associated endothelial cells is a primary target for therapy with tyrosine kinase inhibitors". Neoplasia. 10 (5): 489–500. doi:10.1593/neo.08200. PMC 2373870. PMID 18472966.

External links


This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Protein tyrosine and serine/threonine kinase Provide feedback

Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity [1]; Serine/threonine-protein kinases, tyrosine-protein kinases, and dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins). This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. It does not include the catalytic domain of dual specificity kinases.

Literature references

  1. Hanks SK, Quinn AM, Hunter T;, Science. 1988;241:42-52.: The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. PUBMED:3291115 EPMC:3291115

  2. Hanks SK, Quinn AM; , Methods Enzymol 1991;200:38-62.: Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. PUBMED:1956325 EPMC:1956325

  3. Hanks SK, Hunter T; , FASEB J 1995;9:576-596.: Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. PUBMED:7768349 EPMC:7768349

  4. Hunter T, Plowman GD; , Trends Biochem Sci 1997;22:18-22.: The protein kinases of budding yeast: six score and more. PUBMED:9020587 EPMC:9020587


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR001245

Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity [ PUBMED:3291115 ]:

  • Serine/threonine-protein kinases
  • Tyrosine-protein kinases
  • Dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)

Protein kinase function is evolutionarily conserved from Escherichia coli to human [ PUBMED:12471243 ]. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation [ PUBMED:12368087 ]. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [ PUBMED:15078142 ], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [ PUBMED:15320712 ].

This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. It does not include catalytic domain of dual specificity kinases.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan PKinase (CL0016), which has the following description:

This superfamily includes the Serine/Threonine- and Tyrosine- protein kinases as well as related kinases that act on non-protein substrates.

The clan contains the following 40 members:

ABC1 AceK Act-Frag_cataly Alpha_kinase APH APH_6_hur Choline_kinase CotH DUF1679 DUF2252 DUF4135 DUF5898 EcKL Fam20C Fructosamin_kin FTA2 Haspin_kinase HipA_C Ins_P5_2-kin IPK IucA_IucC Kdo Kinase-like Kinase-PolyVal KIND Pan3_PK PI3_PI4_kinase PIP49_C PIP5K PK_Tyr_Ser-Thr Pkinase Pkinase_fungal Pox_ser-thr_kin RIO1 Seadorna_VP7 TCAD9 UL97 WaaY YrbL-PhoP_reg YukC

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(119)
Full
(187300)
Representative proteomes UniProt
(300896)
RP15
(32464)
RP35
(90091)
RP55
(158695)
RP75
(205823)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(119)
Full
(187300)
Representative proteomes UniProt
(300896)
RP15
(32464)
RP35
(90091)
RP55
(158695)
RP75
(205823)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(119)
Full
(187300)
Representative proteomes UniProt
(300896)
RP15
(32464)
RP35
(90091)
RP55
(158695)
RP75
(205823)
Raw Stockholm Download     Download   Download        
Gzipped Download     Download   Download        

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Unknown
Previous IDs: Pkinase_Tyr;
Type: Domain
Sequence Ontology: SO:0000417
Author: Studholme DJ
Number in seed: 119
Number in full: 187300
Average length of the domain: 231.90 aa
Average identity of full alignment: 24 %
Average coverage of the sequence by the domain: 35.05 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 23.1 23.1
Trusted cut-off 23.1 23.1
Noise cut-off 23.0 23.0
Model length: 259
Family (HMM) version: 19
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the PK_Tyr_Ser-Thr domain has been found. There are 2991 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

Loading structure mapping...

AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A061ADQ6 View 3D Structure Click here
A0A078BQP2 View 3D Structure Click here
A0A096QLV7 View 3D Structure Click here
A0A096T7Z1 View 3D Structure Click here
A0A096UDL3 View 3D Structure Click here
A0A0A0MPK4 View 3D Structure Click here
A0A0B4J3H6 View 3D Structure Click here
A0A0B4K7J3 View 3D Structure Click here
A0A0G2JW59 View 3D Structure Click here
A0A0G2JY48 View 3D Structure Click here
A0A0G2K134 View 3D Structure Click here
A0A0G2K210 View 3D Structure Click here
A0A0G2KA94 View 3D Structure Click here
A0A0G2KGK2 View 3D Structure Click here
A0A0G2L6L8 View 3D Structure Click here
A0A0H2UKT8 View 3D Structure Click here
A0A0H2UKW5 View 3D Structure Click here
A0A0K3ARA3 View 3D Structure Click here
A0A0K3AV08 View 3D Structure Click here
A0A0N7KCC6 View 3D Structure Click here
A0A0N7KCU3 View 3D Structure Click here
A0A0N7KCU3 View 3D Structure Click here
A0A0N7KH38 View 3D Structure Click here
A0A0N7KHL0 View 3D Structure Click here
A0A0N7KJP7 View 3D Structure Click here
A0A0N7KJS0 View 3D Structure Click here
A0A0N7KKC7 View 3D Structure Click here
A0A0N7KKF3 View 3D Structure Click here
A0A0N7KL32 View 3D Structure Click here
A0A0N7KL44 View 3D Structure Click here
A0A0N7KNG2 View 3D Structure Click here
A0A0N7KNG2 View 3D Structure Click here
A0A0N7KNK9 View 3D Structure Click here
A0A0N7KNL2 View 3D Structure Click here
A0A0N7KNW9 View 3D Structure Click here
A0A0N7KQ36 View 3D Structure Click here
A0A0N7KQM4 View 3D Structure Click here
A0A0N7KQM4 View 3D Structure Click here
A0A0N7KR97 View 3D Structure Click here
A0A0N7KRC9 View 3D Structure Click here
A0A0N7KT20 View 3D Structure Click here
A0A0N7KT65 View 3D Structure Click here
A0A0N7KTC7 View 3D Structure Click here
A0A0N7KTD6 View 3D Structure Click here
A0A0N7KTH7 View 3D Structure Click here
A0A0P0UXM0 View 3D Structure Click here
A0A0P0UXP2 View 3D Structure Click here
A0A0P0UXQ9 View 3D Structure Click here
A0A0P0UY10 View 3D Structure Click here
A0A0P0UYG1 View 3D Structure Click here
A0A0P0V290 View 3D Structure Click here
A0A0P0V3S2 View 3D Structure Click here
A0A0P0V3S8 View 3D Structure Click here
A0A0P0V497 View 3D Structure Click here
A0A0P0V4D1 View 3D Structure Click here
A0A0P0V6U7 View 3D Structure Click here
A0A0P0V818 View 3D Structure Click here
A0A0P0V9F1 View 3D Structure Click here
A0A0P0V9G7 View 3D Structure Click here
A0A0P0V9M1 View 3D Structure Click here
A0A0P0V9U1 View 3D Structure Click here
A0A0P0VCW0 View 3D Structure Click here
A0A0P0VDI8 View 3D Structure Click here
A0A0P0VDQ9 View 3D Structure Click here
A0A0P0VEY1 View 3D Structure Click here
A0A0P0VFB2 View 3D Structure Click here
A0A0P0VG12 View 3D Structure Click here
A0A0P0VGB8 View 3D Structure Click here
A0A0P0VHD2 View 3D Structure Click here
A0A0P0VJX9 View 3D Structure Click here
A0A0P0VN93 View 3D Structure Click here
A0A0P0VQA6 View 3D Structure Click here
A0A0P0VQR0 View 3D Structure Click here
A0A0P0VQZ4 View 3D Structure Click here
A0A0P0VR11 View 3D Structure Click here
A0A0P0VTK6 View 3D Structure Click here
A0A0P0VUY2 View 3D Structure Click here
A0A0P0VYC3 View 3D Structure Click here
A0A0P0W282 View 3D Structure Click here
A0A0P0W3C8 View 3D Structure Click here
A0A0P0W3M6 View 3D Structure Click here
A0A0P0W456 View 3D Structure Click here
A0A0P0W6L0 View 3D Structure Click here
A0A0P0W6Q5 View 3D Structure Click here
A0A0P0W6Z5 View 3D Structure Click here
A0A0P0W777 View 3D Structure Click here
A0A0P0W899 View 3D Structure Click here
A0A0P0W950 View 3D Structure Click here
A0A0P0WBD3 View 3D Structure Click here
A0A0P0WF66 View 3D Structure Click here
A0A0P0WF77 View 3D Structure Click here
A0A0P0WF87 View 3D Structure Click here
A0A0P0WF95 View 3D Structure Click here
A0A0P0WFH6 View 3D Structure Click here
A0A0P0WGQ6 View 3D Structure Click here
A0A0P0WHS6 View 3D Structure Click here
A0A0P0WJV8 View 3D Structure Click here
A0A0P0WK53 View 3D Structure Click here
A0A0P0WKH3 View 3D Structure Click here
A0A0P0WKX1 View 3D Structure Click here
A0A0P0WLE3 View 3D Structure Click here
A0A0P0WPP1 View 3D Structure Click here
A0A0P0WPZ4 View 3D Structure Click here
A0A0P0WPZ5 View 3D Structure Click here
A0A0P0WQ48 View 3D Structure Click here
A0A0P0WQI5 View 3D Structure Click here
A0A0P0WR41 View 3D Structure Click here
A0A0P0WRM0 View 3D Structure Click here
A0A0P0WTA9 View 3D Structure Click here
A0A0P0WX42 View 3D Structure Click here
A0A0P0WYQ5 View 3D Structure Click here
A0A0P0WZH7 View 3D Structure Click here
A0A0P0X115 View 3D Structure Click here
A0A0P0X3A4 View 3D Structure Click here
A0A0P0X3R1 View 3D Structure Click here
A0A0P0X5A7 View 3D Structure Click here
A0A0P0X5D2 View 3D Structure Click here
A0A0P0X5M6 View 3D Structure Click here
A0A0P0X648 View 3D Structure Click here
A0A0P0X671 View 3D Structure Click here
A0A0P0X6D5 View 3D Structure Click here
A0A0P0X6M1 View 3D Structure Click here
A0A0P0X7E8 View 3D Structure Click here
A0A0P0X7K2 View 3D Structure Click here
A0A0P0X7K2 View 3D Structure Click here
A0A0P0X7Q1 View 3D Structure Click here
A0A0P0X7T6 View 3D Structure Click here
A0A0P0X9Z0 View 3D Structure Click here
A0A0P0XCI7 View 3D Structure Click here
A0A0P0XDF2 View 3D Structure Click here
A0A0P0XDF8 View 3D Structure Click here
A0A0P0XF07 View 3D Structure Click here
A0A0P0XHB5 View 3D Structure Click here
A0A0P0XHR4 View 3D Structure Click here
A0A0P0XI97 View 3D Structure Click here
A0A0P0XII1 View 3D Structure Click here
A0A0P0XJE6 View 3D Structure Click here
A0A0P0XK25 View 3D Structure Click here
A0A0P0XKH9 View 3D Structure Click here
A0A0P0XKH9 View 3D Structure Click here
A0A0P0XKJ4 View 3D Structure Click here
A0A0P0XKU7 View 3D Structure Click here
A0A0P0XLA2 View 3D Structure Click here
A0A0P0XLH2 View 3D Structure Click here
A0A0P0XLK2 View 3D Structure Click here
A0A0P0XLS4 View 3D Structure Click here
A0A0P0XLU8 View 3D Structure Click here
A0A0P0XLW7 View 3D Structure Click here
A0A0P0XM28 View 3D Structure Click here
A0A0P0XMD4 View 3D Structure Click here
A0A0P0XMF0 View 3D Structure Click here
A0A0P0XML9 View 3D Structure Click here
A0A0P0XN81 View 3D Structure Click here
A0A0P0XPL0 View 3D Structure Click here
A0A0P0XPP4 View 3D Structure Click here
A0A0P0XPZ9 View 3D Structure Click here
A0A0P0XQ04 View 3D Structure Click here
A0A0P0XQ32 View 3D Structure Click here
A0A0P0XQJ7 View 3D Structure Click here
A0A0P0XQJ7 View 3D Structure Click here
A0A0P0XQM6 View 3D Structure Click here
A0A0P0XR76 View 3D Structure Click here
A0A0P0XRC1 View 3D Structure Click here
A0A0P0XRC3 View 3D Structure Click here
A0A0P0XRM2 View 3D Structure Click here
A0A0P0XRM2 View 3D Structure Click here
A0A0P0XRU9 View 3D Structure Click here
A0A0P0XS42 View 3D Structure Click here
A0A0P0XSB2 View 3D Structure Click here
A0A0P0XSR8 View 3D Structure Click here
A0A0P0XZG4 View 3D Structure Click here
A0A0P0Y0Y5 View 3D Structure Click here
A0A0P0Y1F5 View 3D Structure Click here
A0A0P0Y1K1 View 3D Structure Click here
A0A0P0Y1W9 View 3D Structure Click here
A0A0P0Y3G5 View 3D Structure Click here
A0A0P0Y4D1 View 3D Structure Click here
A0A0P0Y544 View 3D Structure Click here
A0A0P0Y563 View 3D Structure Click here
A0A0P0Y5F3 View 3D Structure Click here
A0A0P0Y5G2 View 3D Structure Click here
A0A0P0Y5G7 View 3D Structure Click here
A0A0P0Y5I3 View 3D Structure Click here
A0A0P0Y5K2 View 3D Structure Click here
A0A0P0Y5L0 View 3D Structure Click here
A0A0P0Y5N1 View 3D Structure Click here
A0A0P0Y5S0 View 3D Structure Click here
A0A0P0Y5Z4 View 3D Structure Click here
A0A0P0Y627 View 3D Structure Click here
A0A0P0YAB3 View 3D Structure Click here
A0A0P0YBK6 View 3D Structure Click here
A0A0P0YBU6 View 3D Structure Click here
A0A0P0YCZ3 View 3D Structure Click here
A0A0R0E2W3 View 3D Structure Click here
A0A0R0E2Z1 View 3D Structure Click here
A0A0R0E332 View 3D Structure Click here
A0A0R0E6U1 View 3D Structure Click here
A0A0R0EB22 View 3D Structure Click here
A0A0R0EBB8 View 3D Structure Click here
A0A0R0EBF0 View 3D Structure Click here
A0A0R0EBJ7 View 3D Structure Click here
A0A0R0EC29 View 3D Structure Click here
A0A0R0ECE5 View 3D Structure Click here
A0A0R0EDF6 View 3D Structure Click here
A0A0R0EG63 View 3D Structure Click here
A0A0R0EHM4 View 3D Structure Click here
A0A0R0EJA0 View 3D Structure Click here
A0A0R0EKD2 View 3D Structure Click here
A0A0R0EMG6 View 3D Structure Click here
A0A0R0EML4 View 3D Structure Click here
A0A0R0EMZ6 View 3D Structure Click here
A0A0R0ENE8 View 3D Structure Click here
A0A0R0EQY1 View 3D Structure Click here
A0A0R0ER32 View 3D Structure Click here
A0A0R0ERG6 View 3D Structure Click here
A0A0R0EVN8 View 3D Structure Click here
A0A0R0EYP5 View 3D Structure Click here
A0A0R0EZH3 View 3D Structure Click here
A0A0R0F002 View 3D Structure Click here
A0A0R0F1G0 View 3D Structure Click here
A0A0R0F325 View 3D Structure Click here
A0A0R0F4A1 View 3D Structure Click here
A0A0R0F4R7 View 3D Structure Click here
A0A0R0F4U7 View 3D Structure Click here
A0A0R0F4Z2 View 3D Structure Click here
A0A0R0F581 View 3D Structure Click here
A0A0R0F6S5 View 3D Structure Click here
A0A0R0F8T7 View 3D Structure Click here
A0A0R0FC26 View 3D Structure Click here
A0A0R0FC81 View 3D Structure Click here
A0A0R0FDG2 View 3D Structure Click here
A0A0R0FDG4 View 3D Structure Click here
A0A0R0FGG9 View 3D Structure Click here
A0A0R0FGJ1 View 3D Structure Click here
A0A0R0FL96 View 3D Structure Click here
A0A0R0FLI5 View 3D Structure Click here
A0A0R0FM08 View 3D Structure Click here
A0A0R0FPB3 View 3D Structure Click here
A0A0R0FPN2 View 3D Structure Click here
A0A0R0FSP4 View 3D Structure Click here
A0A0R0FSQ6 View 3D Structure Click here
A0A0R0FVB4 View 3D Structure Click here
A0A0R0FW81 View 3D Structure Click here
A0A0R0FWL3 View 3D Structure Click here
A0A0R0FWY9 View 3D Structure Click here
A0A0R0FWY9 View 3D Structure Click here
A0A0R0FX72 View 3D Structure Click here
A0A0R0FXR9 View 3D Structure Click here
A0A0R0FZ89 View 3D Structure Click here
A0A0R0FZL0 View 3D Structure Click here
A0A0R0G011 View 3D Structure Click here
A0A0R0G011 View 3D Structure Click here
A0A0R0G1N4 View 3D Structure Click here
A0A0R0G3T6 View 3D Structure Click here
A0A0R0G4E6 View 3D Structure Click here
A0A0R0G587 View 3D Structure Click here
A0A0R0G5X7 View 3D Structure Click here
A0A0R0G5Y0 View 3D Structure Click here
A0A0R0G645 View 3D Structure Click here
A0A0R0G676 View 3D Structure Click here
A0A0R0G6Z9 View 3D Structure Click here
A0A0R0G8W2 View 3D Structure Click here
A0A0R0G8Z7 View 3D Structure Click here
A0A0R0G9C9 View 3D Structure Click here
A0A0R0G9R2 View 3D Structure Click here
A0A0R0GA79 View 3D Structure Click here
A0A0R0GAP8 View 3D Structure Click here
A0A0R0GBH3 View 3D Structure Click here
A0A0R0GCN8 View 3D Structure Click here
A0A0R0GHM5 View 3D Structure Click here
A0A0R0GIH9 View 3D Structure Click here
A0A0R0GIK5 View 3D Structure Click here
A0A0R0GIX6 View 3D Structure Click here
A0A0R0GJD8 View 3D Structure Click here
A0A0R0GLB6 View 3D Structure Click here
A0A0R0GPJ5 View 3D Structure Click here
A0A0R0GSW4 View 3D Structure Click here
A0A0R0GT27 View 3D Structure Click here
A0A0R0GT69 View 3D Structure Click here
A0A0R0GTK5 View 3D Structure Click here
A0A0R0GUE9 View 3D Structure Click here
A0A0R0GV60 View 3D Structure Click here
A0A0R0GX78 View 3D Structure Click here
A0A0R0GZH7 View 3D Structure Click here
A0A0R0H043 View 3D Structure Click here
A0A0R0H1X9 View 3D Structure Click here
A0A0R0H291 View 3D Structure Click here
A0A0R0H4C9 View 3D Structure Click here
A0A0R0H4C9 View 3D Structure Click here
A0A0R0H4D4 View 3D Structure Click here
A0A0R0H5T0 View 3D Structure Click here
A0A0R0H5Y2 View 3D Structure Click here
A0A0R0H697 View 3D Structure Click here
A0A0R0H8S0 View 3D Structure Click here
A0A0R0H9A9 View 3D Structure Click here
A0A0R0HA91 View 3D Structure Click here
A0A0R0HCH7 View 3D Structure Click here
A0A0R0HDR1 View 3D Structure Click here
A0A0R0HDU4 View 3D Structure Click here
A0A0R0HES2 View 3D Structure Click here
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