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25  structures 8357  species 0  interactions 22456  sequences 134  architectures

Family: Peptidase_S26 (PF10502)

Summary: Signal peptidase, peptidase S26

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Signal peptidase, peptidase S26 Provide feedback

This is a family of membrane signal serine endopeptidases which function in the processing of newly-synthesised secreted proteins. Peptidase S26 removes the hydrophobic, N-terminal, signal peptides as proteins are translocated across membranes. The active site residues take the form of a catalytic dyad that is Ser, Lys in subfamily S26A; the Ser is the nucleophile in catalysis, and the Lys is the general base.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR019533

This entry represents a domain found in some members of the S26A/S25C family of serine endopeptidases. Peptidases S26A (signal peptidase I) removes the hydrophobic, N-terminal signal peptides as proteins are translocated across membranes. Peptidases 26C (TraF signal peptidase) are found in operons that encode elements of conjugative transfer systems.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Peptidase_SF (CL0299), which has the following description:

This clan includes the peptidase S24 and S26 families. These families adopt a mainly beta fold. Members of the family S24 have an additional C-terminal domain containing a bundle of three helices presumably important for binding DNA.

The clan contains the following 3 members:

Peptidase_S24 Peptidase_S26 Phage_CI_C

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(71)
Full
(22456)
Representative proteomes UniProt
(89423)
RP15
(3156)
RP35
(10881)
RP55
(21724)
RP75
(35618)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(71)
Full
(22456)
Representative proteomes UniProt
(89423)
RP15
(3156)
RP35
(10881)
RP55
(21724)
RP75
(35618)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(71)
Full
(22456)
Representative proteomes UniProt
(89423)
RP15
(3156)
RP35
(10881)
RP55
(21724)
RP75
(35618)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Manual
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Mistry J , Rawlings ND
Number in seed: 71
Number in full: 22456
Average length of the domain: 153.50 aa
Average identity of full alignment: 23 %
Average coverage of the sequence by the domain: 71.64 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 22.9 22.9
Trusted cut-off 22.9 22.9
Noise cut-off 22.8 22.8
Model length: 170
Family (HMM) version: 11
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
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Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Peptidase_S26 domain has been found. There are 25 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0P0VT29 View 3D Structure Click here
A0A0P0VT29 View 3D Structure Click here
A0A0R0GQS6 View 3D Structure Click here
A0A1D6EFB1 View 3D Structure Click here
A0A1D6EFB1 View 3D Structure Click here
A0A1D6F845 View 3D Structure Click here
A0A1D6GGF0 View 3D Structure Click here
A0A1D6H558 View 3D Structure Click here
A0A1D6I0D8 View 3D Structure Click here
A0A1D6I5Q0 View 3D Structure Click here
A0A1D6JNR1 View 3D Structure Click here
A0A1D6JNR1 View 3D Structure Click here
A0A1D6L5X4 View 3D Structure Click here
A0A1D6L5X4 View 3D Structure Click here
A0A1D6L610 View 3D Structure Click here
A0A1D6NB37 View 3D Structure Click here
A0A1D6PQA1 View 3D Structure Click here
A0A1D6PQA1 View 3D Structure Click here
A0A1D8PN24 View 3D Structure Click here
A0A1D8PN24 View 3D Structure Click here
A0A2R8PY00 View 3D Structure Click here
A0A368UMI2 View 3D Structure Click here
A0A5K1K8B7 View 3D Structure Click here
A4ICW7 View 3D Structure Click here
B4FU77 View 3D Structure Click here
B6UIG2 View 3D Structure Click here
B6UIG2 View 3D Structure Click here
C6SYB4 View 3D Structure Click here
C6SYB4 View 3D Structure Click here
D3ZWF3 View 3D Structure Click here
D3ZWF3 View 3D Structure Click here
E7FGX8 View 3D Structure Click here
E7FGX8 View 3D Structure Click here
I1JTG1 View 3D Structure Click here
I1K5V4 View 3D Structure Click here
I1KAD4 View 3D Structure Click here
I1KQ16 View 3D Structure Click here
I1M0L4 View 3D Structure Click here
I1M0Q9 View 3D Structure Click here
I1M2T2 View 3D Structure Click here
I1M2T2 View 3D Structure Click here
I1MIY3 View 3D Structure Click here
I1N2W8 View 3D Structure Click here
I1N2W8 View 3D Structure Click here
K7M0K7 View 3D Structure Click here
K7TXB6 View 3D Structure Click here
K7TXB6 View 3D Structure Click here
O04348 View 3D Structure Click here
O74800 View 3D Structure Click here
O74800 View 3D Structure Click here
P00803 View 3D Structure Click here
P28627 View 3D Structure Click here
P28627 View 3D Structure Click here
P46972 View 3D Structure Click here
P46972 View 3D Structure Click here
P9WKA1 View 3D Structure Click here
Q0IRL1 View 3D Structure Click here
Q0IRL1 View 3D Structure Click here
Q2FZT7 View 3D Structure Click here
Q2FZT8 View 3D Structure Click here
Q4CNX2 View 3D Structure Click here
Q4D5W8 View 3D Structure Click here
Q4DIR9 View 3D Structure Click here
Q4DSS4 View 3D Structure Click here
Q4QQ12 View 3D Structure Click here
Q4QQ12 View 3D Structure Click here
Q54RP1 View 3D Structure Click here
Q54RP1 View 3D Structure Click here
Q5AHZ1 View 3D Structure Click here
Q5BIV4 View 3D Structure Click here
Q5BIV4 View 3D Structure Click here
Q67UZ3 View 3D Structure Click here
Q67XF2 View 3D Structure Click here
Q67XF2 View 3D Structure Click here
Q6AZD4 View 3D Structure Click here
Q6AZD4 View 3D Structure Click here
Q6ERV1 View 3D Structure Click here
Q6NLT8 View 3D Structure Click here
Q6NLT8 View 3D Structure Click here
Q7XS59 View 3D Structure Click here
Q7XS59 View 3D Structure Click here
Q7Y0D0 View 3D Structure Click here
Q8BPT6 View 3D Structure Click here
Q8BPT6 View 3D Structure Click here
Q8H0W1 View 3D Structure Click here
Q96LU5 View 3D Structure Click here
Q96LU5 View 3D Structure Click here
Q96T52 View 3D Structure Click here
Q96T52 View 3D Structure Click here
Q9CQU8 View 3D Structure Click here
Q9CQU8 View 3D Structure Click here
Q9M9Z2 View 3D Structure Click here
Q9N371 View 3D Structure Click here
Q9N371 View 3D Structure Click here
Q9S724 View 3D Structure Click here
Q9S724 View 3D Structure Click here
Q9UST2 View 3D Structure Click here
Q9VXR8 View 3D Structure Click here
Q9XVD2 View 3D Structure Click here
Q9XVD2 View 3D Structure Click here