Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
59  structures 451  species 0  interactions 16500  sequences 887  architectures

Family: TIR (PF01582)

Summary: TIR domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Toll-Interleukin receptor". More...

Toll-Interleukin receptor Edit Wikipedia article

TIR domain
PDB 2js7 EBI.png
Structure of the MyD88 TIR domain
Identifiers
SymbolTIR
PfamPF01582
InterProIPR000157
SCOPe1fyv / SUPFAM
OPM superfamily289
OPM protein2mk9
Membranome7

The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signaling domain found in MyD88, interleukin-1 receptors, Toll receptors and many plant R proteins. It contains three highly conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 (UniProt Q99836) and TOLLIP (Toll interacting protein, UniProt Q9H0E2). In turn, these associate with various kinases to set off signaling cascades.

In Drosophila melanogaster the Toll protein is involved in establishment of dorso-ventral polarity in the embryo. In addition, members of the Toll family play a key role in innate antibacterial and antifungal immunity in insects as well as in mammals. These proteins are type-I transmembrane receptors that share an intracellular 200 residue domain with the interleukin-1 receptor (IL-1R), the Toll/IL-1R homologous region (TIR). The similarity between Toll-like receptors (TLRs) and IL-1R is not restricted to sequence homology since these proteins also share a similar signaling pathway. They both induce the activation of a Rel type transcription factor via an adaptor protein and a protein kinase.[1] MyD88, a cytoplasmic adaptor protein found in mammals, contains a TIR domain associated to a DEATH domain (see InterProIPR000488).[1][2][3] Besides the mammalian and Drosophila melanogaster proteins, a TIR domain is also found in a number of plant proteins implicated in host defense.[4] As MyD88, these proteins are cytoplasmic.

Site directed mutagenesis and deletion analysis have shown that the TIR domain is essential for Toll and IL-1R activities. Sequence analysis have revealed the presence of three highly conserved regions among the different members of the family: box 1 (FDAFISY), box 2 (GYKLC-RD-PG), and box 3 (a conserved W surrounded by basic residues). It has been proposed that boxes 1 and 2 are involved in the binding of proteins involved in signaling, whereas box 3 is primarily involved in directing localization of receptor, perhaps through interactions with cytoskeletal elements.[5]

Subfamilies

Human proteins containing this domain

IL18R1; IL18RAP; IL1R1; IL1RAP; IL1RAPL1; IL1RAPL2; IL1RL1; IL1RL2; MYD88; SIGIRR; TLR1; TLR10; TLR2; TLR3; TLR4; TLR5; TLR6; TLR7; TLR8; TLR9;

References

  1. ^ a b Bonnert TP, Garka KE, Parnet P, Sims JE, Mitcham JL, Gerhart MJ, Slack JL, Gayle MA, Dower SK (1996). "T1/ST2 signaling establishes it as a member of an expanding interleukin-1 receptor family". J. Biol. Chem. 271 (10): 5777–5783. doi:10.1074/jbc.271.10.5777. PMID 8621445.
  2. ^ Dixit VM, Muzio M, Ni J, Feng P (1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science. 278 (5343): 1612–1615. doi:10.1126/science.278.5343.1612. PMID 9374458.
  3. ^ Anderson KV (2000). "Toll signaling pathways in the innate immune response". Curr. Opin. Immunol. 12 (1): 13–19. doi:10.1016/s0952-7915(99)00045-x. PMID 10679407.
  4. ^ Van der Biezen EA, Jones JD (1998). "Plant disease-resistance proteins and the gene-for-gene concept". Trends Biochem. Sci. 23 (12): 454–456. doi:10.1016/s0968-0004(98)01311-5. PMID 9868361.
  5. ^ Bonnert TP, Sims JE, Schooley K, Mitcham JL, Slack JL, Dower SK, Qwarnstrom EE (2000). "Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways". J. Biol. Chem. 275 (7): 4670–4678. doi:10.1074/jbc.275.7.4670. PMID 10671496.
This article incorporates text from the public domain Pfam and InterPro: IPR000157

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

TIR domain Provide feedback

The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 (Q99836) and TOLLIP (Toll interacting protein, Q9H0E2). In turn, these associate with various kinases to set off signalling cascades [3].

Literature references

  1. Bonnert TP, Garka KE, Parnet P, Sonoda G, Testa JR, Sims JE; , FEBS Lett 1997;402:81-84.: The cloning and characterization of human MyD88: a member of an IL-1 receptor related family. PUBMED:9013863 EPMC:9013863

  2. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr; , Nature 1997;388:394-397.: A human homologue of the Drosophila Toll protein signals activation of adaptive immunity [see comments] PUBMED:9237759 EPMC:9237759

  3. Armant MA, Fenton MJ; , Genome Biol 2002;3:REVIEWS3011.: Toll-like receptors: a family of pattern-recognition receptors in mammals. PUBMED:12186654 EPMC:12186654


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR000157

Toll proteins or Toll-like receptors (TLRs) and the interleukin-1 receptor (IL-1R) superfamily are both involved in innate antibacterial and antifungal immunity in insects as well as in mammals. These receptors share a conserved cytoplasmic domain of approximately 200 amino acids, known as the Toll/IL-1R homologous region (TIR). The similarity between TLRs and IL-1Rs is not restricted to sequence homology since these proteins also share a similar signaling pathway. They both induce the activation of a Rel type transcription factor via an adaptor protein and a protein kinase [ PUBMED:10231569 ]. Interestingly, MyD88, a cytoplasmic adaptor protein found in mammals, contains a TIR domain associated to a DEATH domain [ PUBMED:8621445 , PUBMED:9374458 , PUBMED:10679407 ]. Besides the mammalian and Drosophila proteins, a TIR domain is also found in a number of plant cytoplasmic proteins implicated in host defense [Van der Biezen E.A., Jones J.D., Trends Biochem. Sci. 23:454-456(1998)].

Site directed mutagenesis and deletion analysis have shown that the TIR domain is essential for Toll and IL-1R activities. Sequence analysis have revealed the presence of three highly conserved regions among the different members of the family: box 1 (FDAFISY), box 2 (GYKLC-RD-PG), and box 3 (a conserved W surrounded by basic residues). It has been proposed that boxes 1 and 2 are involved in the binding of proteins involved in signalling, whereas box 3 is primarily involved in directing localization of receptor, perhaps through interactions with cytoskeletal elements [ PUBMED:10671496 ].

Resolution of the crystal structures of the TIR domains of human Toll-like receptors 1 and 2 has shown that they contain a central five-stranded parallel beta-sheet that is surrounded by a total of five helices on both sides [ PUBMED:11081518 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

Loading domain graphics...

Pfam Clan

This family is a member of clan STIR (CL0173), which has the following description:

Both members of this clan are thought to be involved in TOLL/IL1R-like pathways, by mediating protein-protein interactions between pathway components. The N-termini of SEFIR and TIR domains are similar, but the domains are more divergent towards the C-terminus [1].

The clan contains the following 6 members:

DUF1863 SEFIR TIR TIR-like TIR_2 TIR_3

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(23)
Full
(16500)
Representative proteomes UniProt
(30812)
RP15
(3139)
RP35
(8428)
RP55
(14781)
RP75
(19372)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(23)
Full
(16500)
Representative proteomes UniProt
(30812)
RP15
(3139)
RP35
(8428)
RP55
(14781)
RP75
(19372)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(23)
Full
(16500)
Representative proteomes UniProt
(30812)
RP15
(3139)
RP35
(8428)
RP55
(14781)
RP75
(19372)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_571 (release 4.1)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Bateman A
Number in seed: 23
Number in full: 16500
Average length of the domain: 158.30 aa
Average identity of full alignment: 22 %
Average coverage of the sequence by the domain: 21.77 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.3 21.3
Trusted cut-off 21.3 21.3
Noise cut-off 21.2 21.2
Model length: 176
Family (HMM) version: 22
Download: download the raw HMM for this family

Species distribution

Sunburst controls

Hide

Weight segments by...


Change the size of the sunburst

Small
Large

Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

Align selected sequences to HMM

Generate a FASTA-format file

Clear selection

This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

Loading sunburst data...

Tree controls

Hide

The tree shows the occurrence of this domain across different species. More...

Loading...

Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the TIR domain has been found. There are 59 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

Loading structure mapping...

AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2K2K7 View 3D Structure Click here
A0A0G2KM01 View 3D Structure Click here
A0A0R0E2U1 View 3D Structure Click here
A0A0R0E307 View 3D Structure Click here
A0A0R0E5K4 View 3D Structure Click here
A0A0R0E807 View 3D Structure Click here
A0A0R0EE48 View 3D Structure Click here
A0A0R0EJF1 View 3D Structure Click here
A0A0R0F079 View 3D Structure Click here
A0A0R0FKV4 View 3D Structure Click here
A0A0R0FN48 View 3D Structure Click here
A0A0R0FN84 View 3D Structure Click here
A0A0R0FQ34 View 3D Structure Click here
A0A0R0FQ34 View 3D Structure Click here
A0A0R0FQC6 View 3D Structure Click here
A0A0R0FQD0 View 3D Structure Click here
A0A0R0FQD6 View 3D Structure Click here
A0A0R0FT41 View 3D Structure Click here
A0A0R0FT79 View 3D Structure Click here
A0A0R0FTC3 View 3D Structure Click here
A0A0R0FTD8 View 3D Structure Click here
A0A0R0FTF9 View 3D Structure Click here
A0A0R0FTG2 View 3D Structure Click here
A0A0R0FTH7 View 3D Structure Click here
A0A0R0FTY7 View 3D Structure Click here
A0A0R0FZ27 View 3D Structure Click here
A0A0R0FZL1 View 3D Structure Click here
A0A0R0G0Q0 View 3D Structure Click here
A0A0R0G194 View 3D Structure Click here
A0A0R0G1J4 View 3D Structure Click here
A0A0R0G1P5 View 3D Structure Click here
A0A0R0G1P9 View 3D Structure Click here
A0A0R0G1Y1 View 3D Structure Click here
A0A0R0G203 View 3D Structure Click here
A0A0R0G2F8 View 3D Structure Click here
A0A0R0G4T7 View 3D Structure Click here
A0A0R0G4X0 View 3D Structure Click here
A0A0R0G9S6 View 3D Structure Click here
A0A0R0G9U0 View 3D Structure Click here
A0A0R0GJV2 View 3D Structure Click here
A0A0R0GKC9 View 3D Structure Click here
A0A0R0GQV9 View 3D Structure Click here
A0A0R0GW30 View 3D Structure Click here
A0A0R0H572 View 3D Structure Click here
A0A0R0H5P2 View 3D Structure Click here
A0A0R0HAA3 View 3D Structure Click here
A0A0R0HDM9 View 3D Structure Click here
A0A0R0HEA3 View 3D Structure Click here
A0A0R0HG01 View 3D Structure Click here
A0A0R0HV98 View 3D Structure Click here
A0A0R0IAY8 View 3D Structure Click here
A0A0R0IDT0 View 3D Structure Click here
A0A0R0IEZ9 View 3D Structure Click here
A0A0R0IFK2 View 3D Structure Click here
A0A0R0IMV1 View 3D Structure Click here
A0A0R0J042 View 3D Structure Click here
A0A0R0J0J4 View 3D Structure Click here
A0A0R0J4I4 View 3D Structure Click here
A0A0R0J6E0 View 3D Structure Click here
A0A0R0JJM6 View 3D Structure Click here
A0A0R0JKE6 View 3D Structure Click here
A0A0R0JLQ6 View 3D Structure Click here
A0A0R0JLQ8 View 3D Structure Click here
A0A0R0JLW9 View 3D Structure Click here
A0A0R0JM06 View 3D Structure Click here
A0A0R0JM07 View 3D Structure Click here
A0A0R0JM07 View 3D Structure Click here
A0A0R0JM07 View 3D Structure Click here
A0A0R0JM20 View 3D Structure Click here
A0A0R0JT19 View 3D Structure Click here
A0A0R0JT99 View 3D Structure Click here
A0A0R0JT99 View 3D Structure Click here
A0A0R0JT99 View 3D Structure Click here
A0A0R0JTT7 View 3D Structure Click here
A0A0R0JXY0 View 3D Structure Click here
A0A0R0JXY0 View 3D Structure Click here
A0A0R0KB65 View 3D Structure Click here
A0A0R0KES8 View 3D Structure Click here
A0A0R0KET5 View 3D Structure Click here
A0A0R0KFL6 View 3D Structure Click here
A0A0R0KGG0 View 3D Structure Click here
A0A0R0KLY1 View 3D Structure Click here
A0A0R0KP92 View 3D Structure Click here
A0A0R0KQA9 View 3D Structure Click here
A0A0R0KY80 View 3D Structure Click here
A0A0R0KZP3 View 3D Structure Click here
A0A0R0L0H1 View 3D Structure Click here
A0A0R0L2V4 View 3D Structure Click here
A0A0R0L5W8 View 3D Structure Click here
A0A0R0L6J4 View 3D Structure Click here
A0A0R0LCQ5 View 3D Structure Click here
A0A0R4IQ68 View 3D Structure Click here
A0A0R4IW15 View 3D Structure Click here
A0A0R4J566 View 3D Structure Click here
A0A0R4J566 View 3D Structure Click here
A0A0U1RS05 View 3D Structure Click here
A0A1D6EZ52 View 3D Structure Click here
A0A1D6F8N7 View 3D Structure Click here
A0A1D6IGT2 View 3D Structure Click here
A0A1I9LTD7 View 3D Structure Click here
A0A1P8AT27 View 3D Structure Click here
A0A1P8B096 View 3D Structure Click here
A0A1P8B6A5 View 3D Structure Click here
A0A1P8B6H3 View 3D Structure Click here
A0A1P8B8A2 View 3D Structure Click here
A0A1P8B9V7 View 3D Structure Click here
A0A1P8BDK2 View 3D Structure Click here
A0A1P8BGN2 View 3D Structure Click here
A0A1W2Q6G2 View 3D Structure Click here
A0A286Y971 View 3D Structure Click here
A0A2R8Q5A0 View 3D Structure Click here
A0A2R8Q6Z1 View 3D Structure Click here
A0A2R8Q9M5 View 3D Structure Click here
A0A2R8QA47 View 3D Structure Click here
A0A2R8QFY0 View 3D Structure Click here
A0A2R8QI87 View 3D Structure Click here
A0A2R8QL77 View 3D Structure Click here
A0A2R8RHT2 View 3D Structure Click here
A0A2R8RJA1 View 3D Structure Click here
A0A2R8RTN4 View 3D Structure Click here
A0A2R8RXV2 View 3D Structure Click here
A0A368UID3 View 3D Structure Click here
A0A368UIT8 View 3D Structure Click here
A0A368UJK8 View 3D Structure Click here
A0A368UL68 View 3D Structure Click here
A1ZBR2 View 3D Structure Click here
A3KH14 View 3D Structure Click here
A4JYJ7 View 3D Structure Click here
A5H2Z9 View 3D Structure Click here
A5H300 View 3D Structure Click here
B3H776 View 3D Structure Click here
B6ZK76 View 3D Structure Click here
B6ZK77 View 3D Structure Click here
B8A689 View 3D Structure Click here
B8A691 View 3D Structure Click here
C6THX9 View 3D Structure Click here
C6TIX3 View 3D Structure Click here
C6TIX3 View 3D Structure Click here
C6ZS22 View 3D Structure Click here
C6ZS32 View 3D Structure Click here
C6ZS32 View 3D Structure Click here
C6ZS33 View 3D Structure Click here
C6ZS34 View 3D Structure Click here
D3ZCT3 View 3D Structure Click here
D3ZRM2 View 3D Structure Click here
D6PT14 View 3D Structure Click here
E7F5V6 View 3D Structure Click here
E7FGC6 View 3D Structure Click here
E9PTD9 View 3D Structure Click here
E9PTL5 View 3D Structure Click here
F1LN63 View 3D Structure Click here
F1QE87 View 3D Structure Click here
F1QMN8 View 3D Structure Click here
F1QRG0 View 3D Structure Click here
F1QWS9 View 3D Structure Click here
F1R2P4 View 3D Structure Click here
F4HR53 View 3D Structure Click here
F4HR54 View 3D Structure Click here
F4HR54 View 3D Structure Click here
F4HT77 View 3D Structure Click here
F4I270 View 3D Structure Click here
F4I3S8 View 3D Structure Click here
F4I552 View 3D Structure Click here
F4I594 View 3D Structure Click here
F4I871 View 3D Structure Click here
F4I901 View 3D Structure Click here
F4I902 View 3D Structure Click here
F4I9F1 View 3D Structure Click here
F4I9N5 View 3D Structure Click here
F4IBL4 View 3D Structure Click here
F4IER8 View 3D Structure Click here
F4IEZ7 View 3D Structure Click here
F4IF04 View 3D Structure Click here
F4IMF2 View 3D Structure Click here
F4ISS7 View 3D Structure Click here
F4IUF0 View 3D Structure Click here
F4J339 View 3D Structure Click here
F4J359 View 3D Structure Click here
F4J361 View 3D Structure Click here
F4JK03 View 3D Structure Click here
F4JNA9 View 3D Structure Click here
F4JNB2 View 3D Structure Click here
F4JNB7 View 3D Structure Click here
F4JNB9 View 3D Structure Click here
F4JNL1 View 3D Structure Click here
F4JNL1 View 3D Structure Click here
F4JNL2 View 3D Structure Click here
F4JT78 View 3D Structure Click here
F4JT78 View 3D Structure Click here
F4JT80 View 3D Structure Click here
F4JT82 View 3D Structure Click here
F4JT82 View 3D Structure Click here
F4JU08 View 3D Structure Click here
F4JU09 View 3D Structure Click here
F4JU10 View 3D Structure Click here
F4JWL7 View 3D Structure Click here
F4JWL8 View 3D Structure Click here
F4JWM0 View 3D Structure Click here
F4JYI4 View 3D Structure Click here
F4K383 View 3D Structure Click here
F4KD45 View 3D Structure Click here
F4KD49 View 3D Structure Click here
F4KFY5 View 3D Structure Click here
F4KHH8 View 3D Structure Click here
F4KHI3 View 3D Structure Click here
F4KIF3 View 3D Structure Click here
F8W4F1 View 3D Structure Click here
G3V695 View 3D Structure Click here
G3V6F8 View 3D Structure Click here
I1J5H4 View 3D Structure Click here
I1JJ81 View 3D Structure Click here
I1JJ81 View 3D Structure Click here
I1JM77 View 3D Structure Click here
I1KDZ9 View 3D Structure Click here
I1KE91 View 3D Structure Click here
I1KE93 View 3D Structure Click here
I1KE99 View 3D Structure Click here
I1KEB4 View 3D Structure Click here
I1KEG1 View 3D Structure Click here
I1KEV5 View 3D Structure Click here
I1L1A5 View 3D Structure Click here
I1LSM9 View 3D Structure Click here
I1LUY0 View 3D Structure Click here
I1LWA0 View 3D Structure Click here
I1M0P9 View 3D Structure Click here
I1M0S0 View 3D Structure Click here
I1MD01 View 3D Structure Click here
I1MM77 View 3D Structure Click here
I1MM78 View 3D Structure Click here
I1MMX8 View 3D Structure Click here
I1MNC5 View 3D Structure Click here
I1MNC7 View 3D Structure Click here
I1MND4 View 3D Structure Click here
I1MND5 View 3D Structure Click here
I1MQE7 View 3D Structure Click here
I1MQI3 View 3D Structure Click here
I1N650 View 3D Structure Click here
I1N6X6 View 3D Structure Click here
K7K1I4 View 3D Structure Click here
K7K1J3 View 3D Structure Click here
K7K360 View 3D Structure Click here
K7K361 View 3D Structure Click here
K7K3C5 View 3D Structure Click here
K7K3H1 View 3D Structure Click here
K7K3H2 View 3D Structure Click here
K7K612 View 3D Structure Click here
K7K6E2 View 3D Structure Click here
K7K9I6 View 3D Structure Click here
K7KB13 View 3D Structure Click here
K7KBB1 View 3D Structure Click here
K7KBB2 View 3D Structure Click here
K7KCX0 View 3D Structure Click here
K7KCX9 View 3D Structure Click here
K7KCZ9 View 3D Structure Click here
K7KD03 View 3D Structure Click here
K7KDG9 View 3D Structure Click here
K7KDI2 View 3D Structure Click here
K7KDW3 View 3D Structure Click here
K7KDW5 View 3D Structure Click here
K7KPR3 View 3D Structure Click here
K7KPR3 View 3D Structure Click here
K7KQM9 View 3D Structure Click here
K7KV37 View 3D Structure Click here
K7KXC7 View 3D Structure Click here
K7KXJ1 View 3D Structure Click here
K7KXJ4 View 3D Structure Click here
K7KXJ4 View 3D Structure Click here
K7KXK7 View 3D Structure Click here
K7KXK7 View 3D Structure Click here
K7KXM9 View 3D Structure Click here
K7KXM9 View 3D Structure Click here
K7KXM9 View 3D Structure Click here
K7KYE4 View 3D Structure Click here
K7KZI3 View 3D Structure Click here
K7L0Z9 View 3D Structure Click here
K7L7M1 View 3D Structure Click here
K7L9P4 View 3D Structure Click here
K7L9Q3 View 3D Structure Click here
K7L9U4 View 3D Structure Click here
K7L9W1 View 3D Structure Click here
K7L9W3 View 3D Structure Click here
K7LBZ9 View 3D Structure Click here
K7LC01 View 3D Structure Click here
K7LE88 View 3D Structure Click here
K7LQJ9 View 3D Structure Click here
K7LSQ4 View 3D Structure Click here
K7LUI6 View 3D Structure Click here
K7LUI7 View 3D Structure Click here
K7LUJ2 View 3D Structure Click here
K7LW75 View 3D Structure Click here
K7LWN3 View 3D Structure Click here
K7LWN5 View 3D Structure Click here
K7LWN7 View 3D Structure Click here
K7LYT2 View 3D Structure Click here
K7M4Z6 View 3D Structure Click here
K7M6W8 View 3D Structure Click here
K7MA27 View 3D Structure Click here
K7MBP2 View 3D Structure Click here
K7MDC7 View 3D Structure Click here
K7MDD3 View 3D Structure Click here
K7MEG0 View 3D Structure Click here
K7MG05 View 3D Structure Click here
K7MG09 View 3D Structure Click here
K7MH68 View 3D Structure Click here
K7MH77 View 3D Structure Click here
K7MHM2 View 3D Structure Click here
K7MHM5 View 3D Structure Click here
K7MHM7 View 3D Structure Click here
K7MIT8 View 3D Structure Click here
K7MIY3 View 3D Structure Click here
K7MIY7 View 3D Structure Click here
K7MIY8 View 3D Structure Click here
K7MIZ0 View 3D Structure Click here
K7MMQ0 View 3D Structure Click here
K7MRQ4 View 3D Structure Click here
K7MWR8 View 3D Structure Click here
K7MWR9 View 3D Structure Click here
K7N0U7 View 3D Structure Click here
K7N1C6 View 3D Structure Click here
M0RAA8 View 3D Structure Click here
O00206 View 3D Structure Click here
O15455 View 3D Structure Click here
O23530 View 3D Structure Click here
O23534 View 3D Structure Click here
O48573 View 3D Structure Click here
O49471 View 3D Structure Click here
O60602 View 3D Structure Click here
O60603 View 3D Structure Click here
O65506 View 3D Structure Click here
O65506 View 3D Structure Click here
O65507 View 3D Structure Click here
O80617 View 3D Structure Click here
O81430 View 3D Structure Click here
O82500 View 3D Structure Click here
O95256 View 3D Structure Click here
P08953 View 3D Structure Click here
P13504 View 3D Structure Click here
P14719 View 3D Structure Click here
P14778 View 3D Structure Click here
P22366 View 3D Structure Click here
P58681 View 3D Structure Click here
P58682 View 3D Structure Click here
P59823 View 3D Structure Click here
P59824 View 3D Structure Click here
Q01638 View 3D Structure Click here
Q02955 View 3D Structure Click here
Q0WPW2 View 3D Structure Click here
Q0WSX8 View 3D Structure Click here
Q13478 View 3D Structure Click here
Q15399 View 3D Structure Click here
Q3EBZ1 View 3D Structure Click here
Q3EDF9 View 3D Structure Click here
Q4V892 View 3D Structure Click here
Q56XU3 View 3D Structure Click here
Q56XU3 View 3D Structure Click here
Q5XJ85 View 3D Structure Click here
Q61098 View 3D Structure Click here
Q61730 View 3D Structure Click here
Q62611 View 3D Structure Click here
Q62929 View 3D Structure Click here
Q63621 View 3D Structure Click here
Q6IA17 View 3D Structure Click here
Q6NPD9 View 3D Structure Click here
Q6R5N8 View 3D Structure Click here
Q6Y1S1 View 3D Structure Click here
Q7K105 View 3D Structure Click here
Q84ZU9 View 3D Structure Click here
Q84ZV1 View 3D Structure Click here
Q84ZV4 View 3D Structure Click here
Q8H1N6 View 3D Structure Click here
Q8H6S7 View 3D Structure Click here
Q99836 View 3D Structure Click here
Q99MB1 View 3D Structure Click here
Q9BXR5 View 3D Structure Click here
Q9C515 View 3D Structure Click here
Q9C5Q9 View 3D Structure Click here
Q9C7X0 View 3D Structure Click here
Q9C931 View 3D Structure Click here
Q9CAD8 View 3D Structure Click here
Q9CAD9 View 3D Structure Click here
Q9CAE0 View 3D Structure Click here
Q9CAK0 View 3D Structure Click here
Q9CAK1 View 3D Structure Click here
Q9EPQ1 View 3D Structure Click here
Q9EPW9 View 3D Structure Click here
Q9EQU3 View 3D Structure Click here
Q9ERS6 View 3D Structure Click here
Q9ERS7 View 3D Structure Click here
Q9FFS5 View 3D Structure Click here
Q9FFS6 View 3D Structure Click here
Q9FGT2 View 3D Structure Click here
Q9FH20 View 3D Structure Click here
Q9FHE5 View 3D Structure Click here
Q9FHE8 View 3D Structure Click here
Q9FHE9 View 3D Structure Click here
Q9FHF0 View 3D Structure Click here
Q9FHF4 View 3D Structure Click here
Q9FHF6 View 3D Structure Click here
Q9FHG0 View 3D Structure Click here
Q9FI14 View 3D Structure Click here
Q9FJG4 View 3D Structure Click here
Q9FKB9 View 3D Structure Click here
Q9FKE2 View 3D Structure Click here
Q9FKE3 View 3D Structure Click here
Q9FKE3 View 3D Structure Click here
Q9FKM8 View 3D Structure Click here
Q9FKM9 View 3D Structure Click here
Q9FKR7 View 3D Structure Click here
Q9FL35 View 3D Structure Click here
Q9FLA7 View 3D Structure Click here
Q9FMB7 View 3D Structure Click here
Q9FN83 View 3D Structure Click here
Q9FT77 View 3D Structure Click here
Q9FVT6 View 3D Structure Click here
Q9FVT9 View 3D Structure Click here
Q9FXA6 View 3D Structure Click here
Q9HB29 View 3D Structure Click here
Q9JLF7 View 3D Structure Click here
Q9JLZ8 View 3D Structure Click here
Q9LFN1 View 3D Structure Click here
Q9LSX5 View 3D Structure Click here
Q9LUJ8 View 3D Structure Click here
Q9M0Q0 View 3D Structure Click here
Q9M285 View 3D Structure Click here
Q9M8X8 View 3D Structure Click here
Q9NP60 View 3D Structure Click here
Q9NPH3 View 3D Structure Click here
Q9NR96 View 3D Structure Click here
Q9NR97 View 3D Structure Click here
Q9NYK1 View 3D Structure Click here
Q9NZN1 View 3D Structure Click here
Q9QUK6 View 3D Structure Click here
Q9QUN7 View 3D Structure Click here
Q9QX05 View 3D Structure Click here
Q9SCZ2 View 3D Structure Click here
Q9SCZ3 View 3D Structure Click here
Q9SKM4 View 3D Structure Click here
Q9SSN1 View 3D Structure Click here
Q9SSN2 View 3D Structure Click here
Q9SSN3 View 3D Structure Click here
Q9SSN4 View 3D Structure Click here
Q9SSN5 View 3D Structure Click here
Q9SSN6 View 3D Structure Click here
Q9SSN9 View 3D Structure Click here
Q9SSP1 View 3D Structure Click here
Q9SUS7 View 3D Structure Click here
Q9SW60 View 3D Structure Click here
Q9SYC9 View 3D Structure Click here
Q9SZ66 View 3D Structure Click here
Q9VIA4 View 3D Structure Click here
Q9VJX9 View 3D Structure Click here
Q9VPH1 View 3D Structure Click here
Q9VUN0 View 3D Structure Click here
Q9XGM3 View 3D Structure Click here
Q9Y2C9 View 3D Structure Click here
Q9Z2B1 View 3D Structure Click here
Q9ZVX6 View 3D Structure Click here