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0  structures 342  species 0  interactions 4434  sequences 1052  architectures

Family: zf-H2C2_2 (PF13465)

Summary: Zinc-finger double domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Zinc-finger double domain Provide feedback

No Pfam abstract.

Internal database links

This tab holds annotation information from the InterPro database.

No InterPro data for this Pfam family.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(108)
Full
(4434)
Representative proteomes UniProt
(8135)
RP15
(1057)
RP35
(1864)
RP55
(4088)
RP75
(5586)
Jalview View  View  View  View  View  View  View 
HTML View  View           
PP/heatmap 1 View           

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(108)
Full
(4434)
Representative proteomes UniProt
(8135)
RP15
(1057)
RP35
(1864)
RP55
(4088)
RP75
(5586)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(108)
Full
(4434)
Representative proteomes UniProt
(8135)
RP15
(1057)
RP35
(1864)
RP55
(4088)
RP75
(5586)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Jackhmmer:D2BGQ7
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Coggill P
Number in seed: 108
Number in full: 4434
Average length of the domain: 25.90 aa
Average identity of full alignment: 62 %
Average coverage of the sequence by the domain: 6.35 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 40.0 40.0
Trusted cut-off 40.0 40.0
Noise cut-off 39.9 39.9
Model length: 26
Family (HMM) version: 8
Download: download the raw HMM for this family

Species distribution

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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2JZM1 View 3D Structure Click here
A0A0G2K5Q4 View 3D Structure Click here
A0A0G2K8T1 View 3D Structure Click here
A0A0G2K9M2 View 3D Structure Click here
A0A0G2K9S0 View 3D Structure Click here
A0A0G2KCQ2 View 3D Structure Click here
A0A0G2KHU9 View 3D Structure Click here
A0A0G2KK90 View 3D Structure Click here
A0A0G2KK90 View 3D Structure Click here
A0A0G2KLM8 View 3D Structure Click here
A0A0G2KPH2 View 3D Structure Click here
A0A0G2KPH2 View 3D Structure Click here
A0A0G2KPN2 View 3D Structure Click here
A0A0G2KQN2 View 3D Structure Click here
A0A0G2KT52 View 3D Structure Click here
A0A0G2KV03 View 3D Structure Click here
A0A0G2KWF9 View 3D Structure Click here
A0A0G2KYV1 View 3D Structure Click here
A0A0G2KYV1 View 3D Structure Click here
A0A0G2KYZ0 View 3D Structure Click here
A0A0G2KZ75 View 3D Structure Click here
A0A0G2KZN8 View 3D Structure Click here
A0A0G2L0M4 View 3D Structure Click here
A0A0G2L0M4 View 3D Structure Click here
A0A0G2L331 View 3D Structure Click here
A0A0G2L6R0 View 3D Structure Click here
A0A0G2L6R0 View 3D Structure Click here
A0A0G2L8H2 View 3D Structure Click here
A0A0G2L8W6 View 3D Structure Click here
A0A0G2L9R8 View 3D Structure Click here
A0A0H2UK38 View 3D Structure Click here
A0A0J9YJ67 View 3D Structure Click here
A0A0R4IEP4 View 3D Structure Click here
A0A0R4IFY6 View 3D Structure Click here
A0A0R4IG96 View 3D Structure Click here
A0A0R4IHQ3 View 3D Structure Click here
A0A0R4IIT7 View 3D Structure Click here
A0A0R4INL2 View 3D Structure Click here
A0A0R4ITI6 View 3D Structure Click here
A0A0R4ITI6 View 3D Structure Click here
A0A0R4ITQ7 View 3D Structure Click here
A0A0R4IUP7 View 3D Structure Click here
A0A0R4IUP7 View 3D Structure Click here
A0A0R4IUP7 View 3D Structure Click here
A0A0R4IUZ3 View 3D Structure Click here
A0A0R4IWK7 View 3D Structure Click here
A0A0R4IWR4 View 3D Structure Click here
A0A0R4IZJ3 View 3D Structure Click here
A0A0U1RQ46 View 3D Structure Click here
A0A0U1RQ46 View 3D Structure Click here
A0A0U1RQ46 View 3D Structure Click here
A0A1B0GR71 View 3D Structure Click here
A0A1B0GR71 View 3D Structure Click here
A0A1D5RM15 View 3D Structure Click here
A0A1L1QZQ8 View 3D Structure Click here
A0A286Y983 View 3D Structure Click here
A0A286Y9D9 View 3D Structure Click here
A0A286YA18 View 3D Structure Click here
A0A286YB60 View 3D Structure Click here
A0A2R8PVU4 View 3D Structure Click here
A0A2R8PX70 View 3D Structure Click here
A0A2R8Q532 View 3D Structure Click here
A0A2R8Q6Y6 View 3D Structure Click here
A0A2R8Q9C9 View 3D Structure Click here
A0A2R8QAY8 View 3D Structure Click here
A0A2R8QDD0 View 3D Structure Click here
A0A2R8QDD0 View 3D Structure Click here
A0A2R8QDN5 View 3D Structure Click here
A0A2R8QFG6 View 3D Structure Click here
A0A2R8QH71 View 3D Structure Click here
A0A2R8QIU4 View 3D Structure Click here
A0A2R8QIU4 View 3D Structure Click here
A0A2R8QRI7 View 3D Structure Click here
A0A2R8QTT7 View 3D Structure Click here
A0A2R8RHP4 View 3D Structure Click here
A0A2R8RKN8 View 3D Structure Click here
A0A2R8RNE9 View 3D Structure Click here
A0A2R9YJN5 View 3D Structure Click here
A0A2R9YJN5 View 3D Structure Click here
A0A3B2WCF4 View 3D Structure Click here
A3KPV2 View 3D Structure Click here
A4VCH2 View 3D Structure Click here
A5GZY2 View 3D Structure Click here
A8DZB8 View 3D Structure Click here
A8KBM4 View 3D Structure Click here
A8MT65 View 3D Structure Click here
B2RZ94 View 3D Structure Click here
D3ZYI6 View 3D Structure Click here
D4A171 View 3D Structure Click here
D4AEC6 View 3D Structure Click here
E7EYM8 View 3D Structure Click here
E7EZN1 View 3D Structure Click here
E7EZN1 View 3D Structure Click here
E7F097 View 3D Structure Click here
E7F311 View 3D Structure Click here
E7F3E4 View 3D Structure Click here
E7F3E4 View 3D Structure Click here
E7F5M6 View 3D Structure Click here
E7F6B3 View 3D Structure Click here
E7F8E6 View 3D Structure Click here
E7FAY5 View 3D Structure Click here
E7FCR0 View 3D Structure Click here
E9QEE1 View 3D Structure Click here
E9QEE1 View 3D Structure Click here
E9QEE1 View 3D Structure Click here
E9QIA7 View 3D Structure Click here
E9QIA7 View 3D Structure Click here
E9QIS6 View 3D Structure Click here
F1LT76 View 3D Structure Click here
F1LXA1 View 3D Structure Click here
F1LXE4 View 3D Structure Click here
F1Q5S4 View 3D Structure Click here
F1Q8J8 View 3D Structure Click here
F1QC22 View 3D Structure Click here
F1QGX9 View 3D Structure Click here
F1QKI8 View 3D Structure Click here
F1QML7 View 3D Structure Click here
F1QML7 View 3D Structure Click here
F1QPF6 View 3D Structure Click here
F1QQR8 View 3D Structure Click here
F1QRU4 View 3D Structure Click here
F1QZ23 View 3D Structure Click here
F1R028 View 3D Structure Click here
F1R028 View 3D Structure Click here
F1R0P2 View 3D Structure Click here
F1R3N6 View 3D Structure Click here
F1R5Q7 View 3D Structure Click here
F1R8E5 View 3D Structure Click here
F1REH3 View 3D Structure Click here
F7AIG4 View 3D Structure Click here
G3X996 View 3D Structure Click here
H0WE42 View 3D Structure Click here
H0WE53 View 3D Structure Click here
H0WE92 View 3D Structure Click here
H0WE92 View 3D Structure Click here
H0WEB1 View 3D Structure Click here
H0WEC9 View 3D Structure Click here
H0WED9 View 3D Structure Click here
H0WEG4 View 3D Structure Click here
H0WEI9 View 3D Structure Click here
H0WEI9 View 3D Structure Click here
H0WEJ1 View 3D Structure Click here
H0WEK9 View 3D Structure Click here
H0WEN8 View 3D Structure Click here
H0WEP1 View 3D Structure Click here
H0WES2 View 3D Structure Click here
H0WEW4 View 3D Structure Click here
H0WEX3 View 3D Structure Click here
H0WEY2 View 3D Structure Click here
H0WEY7 View 3D Structure Click here
H0WF00 View 3D Structure Click here
H0WF05 View 3D Structure Click here
H0WF55 View 3D Structure Click here
H0WF80 View 3D Structure Click here
H0WFH9 View 3D Structure Click here
H9GYZ1 View 3D Structure Click here
J3QPX0 View 3D Structure Click here
K7DY22 View 3D Structure Click here
K7DY22 View 3D Structure Click here
K7DY22 View 3D Structure Click here
K7DYE8 View 3D Structure Click here
K7DYF2 View 3D Structure Click here
K7DYF2 View 3D Structure Click here
K7N6H3 View 3D Structure Click here
K7N769 View 3D Structure Click here
L7N208 View 3D Structure Click here
L7N248 View 3D Structure Click here
O14753 View 3D Structure Click here
O88253 View 3D Structure Click here
O88253 View 3D Structure Click here
P08042 View 3D Structure Click here
P0CG31 View 3D Structure Click here
P17029 View 3D Structure Click here
P51523 View 3D Structure Click here
Q0VFY0 View 3D Structure Click here
Q12132 View 3D Structure Click here
Q13360 View 3D Structure Click here
Q14585 View 3D Structure Click here
Q14585 View 3D Structure Click here
Q147U1 View 3D Structure Click here
Q1LVU5 View 3D Structure Click here
Q499D5 View 3D Structure Click here
Q4KLI1 View 3D Structure Click here
Q56A57 View 3D Structure Click here
Q5FWU5 View 3D Structure Click here
Q5SXM1 View 3D Structure Click here
Q6P2D0 View 3D Structure Click here
Q6PD29 View 3D Structure Click here
Q8BGS3 View 3D Structure Click here
Q8BZW4 View 3D Structure Click here
Q8N7Q3 View 3D Structure Click here
Q8N8E2 View 3D Structure Click here
Q8N988 View 3D Structure Click here
Q8NA42 View 3D Structure Click here
Q8TAQ5 View 3D Structure Click here
Q8TC21 View 3D Structure Click here
Q8VCI1 View 3D Structure Click here
Q969W8 View 3D Structure Click here
Q96JL9 View 3D Structure Click here
Q96NL3 View 3D Structure Click here
Q99K45 View 3D Structure Click here
Q9ERR8 View 3D Structure Click here
Q9HBT8 View 3D Structure Click here
Q9JIC0 View 3D Structure Click here
Q9P2F9 View 3D Structure Click here
Q9WTJ2 View 3D Structure Click here
U3JAF5 View 3D Structure Click here
U3JAF5 View 3D Structure Click here
U3JAF5 View 3D Structure Click here
X1WB91 View 3D Structure Click here
X1WCL9 View 3D Structure Click here
X1WCL9 View 3D Structure Click here
X1WCL9 View 3D Structure Click here
X1WED3 View 3D Structure Click here
X1WEY0 View 3D Structure Click here
X1WFL8 View 3D Structure Click here
X1WG69 View 3D Structure Click here
X1WHR9 View 3D Structure Click here

trRosetta Structure

The structural model below was generated by the Baker group with the trRosetta software using the Pfam UniProt multiple sequence alignment.

The InterPro website shows the contact map for the Pfam SEED alignment. Hovering or clicking on a contact position will highlight its connection to other residues in the alignment, as well as on the 3D structure.

Improved protein structure prediction using predicted inter-residue orientations. Jianyi Yang, Ivan Anishchenko, Hahnbeom Park, Zhenling Peng, Sergey Ovchinnikov, David Baker Proceedings of the National Academy of Sciences Jan 2020, 117 (3) 1496-1503; DOI: 10.1073/pnas.1914677117;