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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: A0A0R4IRY4_DANRE (A0A0R4IRY4)

Summary

This is the summary of UniProt entry A0A0R4IRY4_DANRE (A0A0R4IRY4).

Description: Rho guanine nucleotide exchange factor (GEF) 12b {ECO:0000313|Ensembl:ENSDARP00000139791}
Source organism: Danio rerio (Zebrafish) (Brachydanio rerio) (NCBI taxonomy ID 7955)
Length: 1419 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 15 37
disorder n/a 39 40
Pfam PDZ 53 125
disorder n/a 87 89
disorder n/a 95 96
disorder n/a 130 182
low_complexity n/a 160 172
disorder n/a 190 259
disorder n/a 261 268
disorder n/a 270 308
disorder n/a 311 313
disorder n/a 317 326
disorder n/a 329 330
Pfam RGS-like 335 532
disorder n/a 414 434
low_complexity n/a 439 451
disorder n/a 479 480
disorder n/a 483 484
disorder n/a 536 537
disorder n/a 542 737
low_complexity n/a 690 700
disorder n/a 744 746
Pfam RhoGEF 762 946
Pfam PH_16 975 1103
disorder n/a 1112 1113
disorder n/a 1115 1132
disorder n/a 1143 1151
disorder n/a 1153 1194
low_complexity n/a 1175 1182
disorder n/a 1211 1212
disorder n/a 1218 1219
disorder n/a 1223 1224
disorder n/a 1226 1229
low_complexity n/a 1235 1246
disorder n/a 1247 1310
disorder n/a 1326 1348
disorder n/a 1350 1379
low_complexity n/a 1356 1366
coiled_coil n/a 1383 1410
disorder n/a 1394 1419

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession A0A0R4IRY4. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
NNSCFSSRFP KKASRTGSIL SKDHPPDKKA KSDKASVPLS HEFDPTGLVQ
50
51
RCVIIQKDEN GFGLTVSGDN PVFVQLVKED GAAMRAGVQT GDRIIKVNGT
100
101
LVTHSNHVEV VKLIKSGSYV ALTVLGRPPG LPQIPLSDGE GEEGSPFSLS
150
151
SPHSPGPIGP ERSCSSPSPS ERKAASLPVW GITEDYRNPT SKLLKEIQDI
200
201
PQNQNQEQLS KPTGQDESIS PRPGEGELED FSGDVDRPPS WQGDAGTEPL
250
251
WTNNNMTPVT PCLFPESPCQ RETPCHSPKT TPRDSLNSCP SPDAEDTPDL
300
301
DSQSSVGSPC SRPVAHIIGA EDEDFGKEQE QMNGQCSCFQ SIDLLKSRPA
350
351
HLAAFIHHVV SQFDPAPLLC YLYADLYKQS STKETRRILM DTFFIDKTAN
400
401
LKVTVPESII ADLERTAHST NAERKRPEQM SEDVHRQYVQ QLQDTLLTDV
450
451
QKNLEDFRHK RSMGLTLAEA ELARLDTERM RDRVALEKER SCAEHILSKI
500
501
EEVLLTSQAT EEDKCSTMQF VILSYMKQLG VKVKELRGLD HKPKLMNPFH
550
551
KIKKSMKPEK DGSEEKAKKT RFPNVFPQRR PSKIDALSQP KQRTPKPQLP
600
601
LGTGEQADGS SLPVRSSQSS EGSDGTNALI TSPPYSAPAG QGTDAISRES
650
651
ETGGLPSSAL PKLGEGTVSG DLQDSSSTNT HFDFSNCMLE HLQEEEAETE
700
701
KTQDSGTPRP DRSRMDPLGS GEVQSEDDQC VEAELEPPNW QTLVSRDVLS
750
751
TLTPQEIKRQ EVINELFYTE RAHVRMMKVL ENLFYQPLIR DAILPPADIK
800
801
NIFSNLEEIV QLHLSLTEQM AAVRKKNETA LIDSIGDDLL SWFSEEEEDK
850
851
IKRAVGTYCS NQPFALELIK SKQKKDQRFN AFIQETESNR HCRRLQLKDI
900
901
IPVETLRLTK YPLLLENIAK YTEDSEERSK VKRAGECCRK ILTHVNQEVK
950
951
EAENKQRLED YQRRLDLSSL KQSENPMIAE FKSLDLTKRK MVHEGPLSWK
1000
1001
VNKDKTIELY TLLLEDILVL LQRQDEKLIL KCHSKNLAGT AETKHIFSPI
1050
1051
IKLSTVMVRS VATDNRSFFV LSMSDNGAQI YELMAQTVSE QKTWQCLITQ
1100
1101
RADCMKTKLH NIIPLPQTDG EREEVEMINS GVQKISKDTE PITLASIQSP
1150
1151
VEKDDTEVIP TPLPSTNPFE TKSDEEAEEE EENSLQDQAE DDEAFVVADL
1200
1201
SDRLTFLKQR SRLGIAIDED EAEVFELQPL IADEALRTLA TLRQLLINHF
1250
1251
SGQEDTDREN KSEDQQEHIE RTCPQQGSDD SAAIQSPLEN GSDRGENPQE
1300
1301
LPSGDTGFFE TSEDCVSAGS YMVLEVFAGS GESSTDDDAQ GCSVEPVAGG
1350
1351
DSGIDLKKLL SSSSQSTGGP NINRQIMTHL RLLQGNLQQL KETEIKYNQL
1400
1401
RQRLSEETAT DTEENKGRA                                  
1419
 

Show the unformatted sequence.

Checksums:
CRC64:48A18FE946889727
MD5:820861f3604b74a2bb9ae65d7a16f891

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;