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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: A0A2R8QLY1_DANRE (A0A2R8QLY1)

Summary

This is the summary of UniProt entry A0A2R8QLY1_DANRE (A0A2R8QLY1).

Description: Sodium channel protein {ECO:0000256|RuleBase:RU361132}
Source organism: Danio rerio (Zebrafish) (Brachydanio rerio) (NCBI taxonomy ID 7955)
Length: 1949 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 4
low_complexity n/a 23 40
disorder n/a 26 57
transmembrane n/a 128 151
Pfam Ion_trans 131 423
transmembrane n/a 196 215
transmembrane n/a 227 248
transmembrane n/a 254 274
transmembrane n/a 349 368
transmembrane n/a 388 415
coiled_coil n/a 412 450
disorder n/a 423 428
low_complexity n/a 424 435
disorder n/a 446 536
low_complexity n/a 459 472
low_complexity n/a 475 490
disorder n/a 538 572
Pfam Na_trans_cytopl 544 671
disorder n/a 574 584
disorder n/a 586 594
low_complexity n/a 622 635
disorder n/a 633 636
transmembrane n/a 691 711
Pfam Ion_trans 721 956
transmembrane n/a 723 741
transmembrane n/a 753 771
transmembrane n/a 791 812
low_complexity n/a 809 821
transmembrane n/a 833 861
low_complexity n/a 849 861
transmembrane n/a 891 908
transmembrane n/a 920 946
low_complexity n/a 935 960
Pfam Na_trans_assoc 960 1162
disorder n/a 1026 1027
low_complexity n/a 1031 1044
disorder n/a 1079 1082
disorder n/a 1085 1086
disorder n/a 1088 1095
low_complexity n/a 1110 1124
Pfam Ion_trans 1166 1443
transmembrane n/a 1168 1186
transmembrane n/a 1207 1226
transmembrane n/a 1238 1258
low_complexity n/a 1263 1278
transmembrane n/a 1284 1310
transmembrane n/a 1407 1433
low_complexity n/a 1407 1423
Pfam Ion_trans 1490 1746
transmembrane n/a 1492 1510
transmembrane n/a 1522 1544
transmembrane n/a 1556 1575
low_complexity n/a 1588 1600
transmembrane n/a 1619 1645
transmembrane n/a 1657 1676
disorder n/a 1695 1701
transmembrane n/a 1712 1735
disorder n/a 1836 1838
disorder n/a 1854 1858
disorder n/a 1895 1949
low_complexity n/a 1931 1945

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession A0A2R8QLY1. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAPLLAPPG PNSYKYFTRE SLREIEKRIE EEKAKPPPKP DNSYRDDDDE
50
51
NKPKPNGDLE AGKSLPFIYG DIPPGMVATP LEDFDPFYIN QKTFVVLNKG
100
101
KTIFRFSATP ALYMISPFNL ARRIAIKILI HSLFSMFIMC TILTNCVFMT
150
151
FSNPPEWSKQ VEYTFTGIYT FESAVKIIAR GFCIDGFTFL RDPWNWLDFM
200
201
VISMAYVTEF VDLGNVSALR TFRVLRALKT ISVIPGLKTI VGALIQSVKK
250
251
LSDVMILTVF CLSVFALIGL QLFMGNLRQK CVIWPINITE MFPDVNGSRA
300
301
FNWDEYILNE TNFYFLPDQL DALLCGNSSD SGRCPEGYTC MKAGRNPNYG
350
351
YTSFDSFGWA FLALFRLMTQ DFWENLYQLT LRAAGKTYMI FFVLVIFVGS
400
401
FYLVNLILAV VAMAYEEQNQ ATMEEAERKE AEFKAMLEQL KKQQEDAQAN
450
451
AMATSAGTVS EDVVEDDGDG EGNLSCSSSE MSKLSSKSAK ERRNRKKKWR
500
501
QKEQDKEKGD SEKFVKSESD DGSRRRFRFP DNRLGRRSSI MNQSLLSIPG
550
551
SPFPSRRNSK SSIFSRCKDG GSENEFADDE HSTVEEYDER RDSFLSPQRR
600
601
SSYTGFYGKR NSTVDCNGVV SLIGPGPGGR LLPEPTTDLE IKKKLSGSLM
650
651
VSVEQLNTSF GRKERANSVM SALTNTLVEE LEESQRKCPP CWYKFANTFL
700
701
IWECGPLWMS IKEIVNLIVM DPFVDLAITI CIVLNTLFMA MEHYPMTPQF
750
751
EHVLSVGNLV FTGIFTAEMF AKLVAMDPYY YFQEGWNIFD GFIVSLSLME
800
801
LGLANVEGLS VLRSFRLLRV FKLAKSWPTL NMLIKIIGNS VGALGNLTLV
850
851
LAIIVFIFAV VGMQLFGKSY KDCVCKIAQD CELPRWHMND FFHSFLIVFR
900
901
VLCGEWIETM WDCMEVAGQA MCLIVFMMVM VIGNLVVLNL FLALLLSSFS
950
951
ADNLAASDDD GEMNNLQIAV IRIKKGIAWV KAKVRELVNI ILGRKVTDEA
1000
1001
KPLDDMYDRK LNCIANHTGV DISRDLDYQK NGNGTTSGIG SSVGKYMIDD
1050
1051
DHMSFIHNPN LTVCVPIAVG ESDFENLNTE DFSSESEAEG SKELDDISSS
1100
1101
EGSTIDIKPE VEEAVVVETV EEYVDPEACW TEACIARYKC CDVPITEGWG
1150
1151
KNWWFLRKTC YLIVEHNWFE TLIIFMILLS SGALAFEDVY IEQRKTIRII
1200
1201
LEYADMVFTY IFILEMLLKW VAYGFVKYFT NAWCWLDFFI VDVSIVSLIA
1250
1251
NALGYSDLGP IKSLRTLRAL RPLRALSRFE GMRVVVNALV GAIPSIMNVL
1300
1301
LVCLIFWLIF SIMGVNMFAG KYYYCYNETE KAYFELDVVN NKSECFALIE
1350
1351
QNYTEVRWKN VKINFDNVGA GYLALLQVAT FKGWMDIMYA AVDSRRVEDQ
1400
1401
PKYEDNIYMY IYFVIFIIFG SFFTLNLFIG VIIDNFNQQK KKFGGQDIFM
1450
1451
TEEQKKYYNA MKKLGSKKPQ KPIPRPQNKL QGMVFDFVTQ QVFDISIMIL
1500
1501
ICLNMVTMMV ETDDQSQETE NILYWINFIF IVAFTSEFVL KLFALRHYYF
1550
1551
TNGWNIFDCV VVILSIVGMF LADLIEKYFV SPTLFRVIRL ARIGRILRLI
1600
1601
KGAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIFSIFGMS NFAYVKRESG
1650
1651
IDDMYNFETF GNSMICLFMI TTSAGWDGLL APILNYPPDC EPTKENPGTS
1700
1701
VKGNCGNPSV GIFFFVMYII VSFLIVVNMY IAIILENFSV ATEESADPLC
1750
1751
EDDFESFYEI WEKFDPTASQ FITFAKLGDF ADTLEHPLRV PKPNTIELIA
1800
1801
MDLPMVSGDR IHCLDILFAF TKRVLGDSGD LDMMRQQMEE RFIAANPSKV
1850
1851
SFEPITTTLR RKQEHMSAGV IQRAFRAHLI RKGFICKRLL SSSRLENGGT
1900
1901
NQDKKEGTPS TASLPSYDSV TKPEKEKLEE SDSKGKKGKN QKDVKESKF 
1949
 

Show the unformatted sequence.

Checksums:
CRC64:BA169A75669DC344
MD5:2ab85cff849e969a10abde156475561c

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;