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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SCN3A_MOUSE (A2ASI5)

Summary

This is the summary of UniProt entry SCN3A_MOUSE (A2ASI5).

Description: Sodium channel protein type 3 subunit alpha
Source organism: Mus musculus (Mouse) (NCBI taxonomy ID 10090)
Length: 1947 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 2
coiled_coil n/a 22 42
low_complexity n/a 23 40
disorder n/a 28 31
disorder n/a 33 52
transmembrane n/a 124 147
Pfam Ion_trans 127 435
transmembrane n/a 192 211
transmembrane n/a 223 244
transmembrane n/a 250 270
transmembrane n/a 400 427
coiled_coil n/a 424 465
low_complexity n/a 432 447
disorder n/a 436 440
disorder n/a 446 447
low_complexity n/a 446 469
low_complexity n/a 473 498
disorder n/a 493 529
low_complexity n/a 500 509
disorder n/a 548 555
Pfam Na_trans_cytopl 558 625
disorder n/a 563 566
disorder n/a 578 581
disorder n/a 588 589
disorder n/a 591 600
disorder n/a 604 632
transmembrane n/a 703 727
Pfam Ion_trans 710 945
transmembrane n/a 739 760
transmembrane n/a 780 801
low_complexity n/a 798 810
transmembrane n/a 822 850
low_complexity n/a 838 850
transmembrane n/a 880 900
transmembrane n/a 912 935
low_complexity n/a 923 945
Pfam Na_trans_assoc 949 1153
low_complexity n/a 1021 1032
disorder n/a 1027 1030
low_complexity n/a 1064 1086
disorder n/a 1069 1073
disorder n/a 1075 1113
Pfam Ion_trans 1157 1430
transmembrane n/a 1159 1177
transmembrane n/a 1198 1220
transmembrane n/a 1226 1246
low_complexity n/a 1254 1269
transmembrane n/a 1275 1301
transmembrane n/a 1396 1420
Pfam Ion_trans 1477 1734
transmembrane n/a 1479 1497
transmembrane n/a 1509 1527
transmembrane n/a 1534 1559
transmembrane n/a 1565 1584
low_complexity n/a 1575 1587
transmembrane n/a 1596 1624
low_complexity n/a 1697 1715
transmembrane n/a 1700 1723
disorder n/a 1841 1844
disorder n/a 1899 1947
low_complexity n/a 1913 1921
low_complexity n/a 1927 1943

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession A2ASI5. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDIDDENKPK
50
51
PNSDLEAGKN LPFIYGDIPP EMVSEPLEDL DPYYVSKKTF VVLNKGKAIF
100
101
RFSATSALYI LTPLNPVRKI AIKILVHSLF SMLIMCTILT NCVFMTLSNP
150
151
PDWTKNVEYT FTGIYTFESL IKILARGFCL EDFTFLRDPW NWLDFSVIVM
200
201
AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL IQSVKKLSDV
250
251
MILTVFCLSV FALIGLQLFM GNLRNKCLQW PPSDSAFEIN TTSYFNGTMD
300
301
SNGTFVNVTM STFNWKDYIA DDSHFYVLDG QKDPLLCGNG SDAGQCPEGY
350
351
ICVKAGRNPN YGYTSFDTFS WAFLSLFRLM TQDYWENLYQ LTLRAAGKTY
400
401
MIFFVLVIFL GSFYLVNLIL AVVAMAYEEQ NQATLEEAEQ KEAEFQQMLE
450
451
QLKKQQEEAQ AVAAASAASR DFSGIGGLGE LLESSSEASK LSSKSAKEWR
500
501
NRRKKRRQRE HLEGNHRPEG DRFPKSESED SVKRRSFLFS LDGNPLSGDK
550
551
KLCSPHQSLL SIRGSLFSPR RNSKTSIFSF RGRAKDVGSE NDFADDEHST
600
601
FEDSESRRDS LFVPHRPGER RNSNGTTTET EVRKRRLSSY QISMEMLEDS
650
651
SGRQRAMSIA SILTNTMEEL EESRQKCPPC WYRFANVFLI WDCCDSWLKV
700
701
KHLVNLIVMD PFVDLAITIC IVLNTLFMAM EHYPMTEQFS SVLTVGNLVF
750
751
TGIFTAEMVL KIIAMDPYYY FQEGWNIFDG IIVSLSLMEL GLANVEGLSV
800
801
LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV
850
851
GMQLFGKSYK ECVCKINEDC KLPRWHMNDF FHSFLIVFRV LCGEWIETMW
900
901
DCMEVAGQTM CLIVFMLVMV IGNLVVLNLF LALLLSSFSS DNLAATDDDN
950
951
EMNNLQIAVG RMQKGIDYVK NKIRECFRKA FFRKPKVIEI HEGNKIDSCM
1000
1001
SNNTGVVEIS KELNYLKDGN GTTSGVGTGS SVEKYVIDEN DYMSFINNPS
1050
1051
LTVTVPIAVG ESDFENLNTE EFSSESELEE SKEKLNATSS SEGSTVDVAP
1100
1101
PREGEQAEIE PEEDLKPEAC FTEGCIKKFP FCQVSTEEGK GKIWWNLRKT
1150
1151
CYSIVEHNWF ETFIVFMILL SSGALAFEDI YIEQRKTIKT MLEYADKVFT
1200
1201
YIFILEMLLK WVAYGFQTYF TNAWCWLDFL IVDVSLVSLV ANALGYSELG
1250
1251
AIKSLRTLRA LRPLRALSRF EGMRVVVNAL VGAIPSIMNV LLVCLIFWLI
1300
1301
FSIMGVNLFA GKFYHCVNMT TGSMFDMSEV NNFSDCQALG KQARWKNVKV
1350
1351
NFDNVGAGYL ALLQVATFKG WMDIMYAAVD SRDVKLQPVY EENLYMYLYF
1400
1401
VIFIIFGSFF TLNLFIGVII DNFNQQKKKF GGQDIFMTEE QKKYYNAMKK
1450
1451
LGSKKPQKPI PRPANKFQGM VFDFVTRQVF DISIMILICL NMVTMMVETD
1500
1501
DQSKYMTLVL SRINLVFIVL FTGEFLLKLI SLRYYYFTIG WNIFDFVVVI
1550
1551
LSIVGMFLAE LIEKYFVSPT LFRVIRLARI GRILRLIKGA KGIRTLLFAL
1600
1601
MMSLPALFNI GLLLFLVMFI YAIFGMSNFA YVKKEAGIDD MFNFETFGNS
1650
1651
MICLFQITTS AGWDGLLAPI LNSAPPDCDP DAIHPGSSVK GDCGNPSVGI
1700
1701
FFFVSYIIIS FLVVVNMYIA VILENFSVAT EESAEPLSED DFEMFYEVWE
1750
1751
KFDPDATQFI EFCKLSDFAA ALDPPLLIAK PNKVQLIAMD LPMVSGDRIH
1800
1801
CLDILFAFTK RVLGESGEMD ALRIQMEDRF MASNPSKVSY EPITTTLKRK
1850
1851
QEEVSAAIIQ RNYRCYLLKQ RLKNISNTYD KETIKGRIVL PIKGDMVIDK
1900
1901
LNGNSTPEKT DGSSSTTSPP SYDSVTKPDK EKFEKDKPEK ESKGKEV   
1947
 

Show the unformatted sequence.

Checksums:
CRC64:B5E01EEC78004E15
MD5:5e8ac4f5dcff1efdd04b65876b77ae5d

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;