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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: A4IAG3_LEIIN (A4IAG3)

Summary

This is the summary of UniProt entry A4IAG3_LEIIN (A4IAG3).

Description: Non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513}
Source organism: Leishmania infantum (NCBI taxonomy ID 5671)
Length: 2628 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
low_complexity n/a 301 313
Pfam DUF3385 736 895
low_complexity n/a 742 762
low_complexity n/a 784 796
disorder n/a 794 795
low_complexity n/a 858 872
disorder n/a 1115 1121
disorder n/a 1126 1127
disorder n/a 1143 1147
disorder n/a 1159 1160
disorder n/a 1203 1212
Pfam FAT 1597 1914
Pfam FRB_dom 2023 2110
Pfam PI3_PI4_kinase 2177 2431
disorder n/a 2438 2455
low_complexity n/a 2453 2469
low_complexity n/a 2463 2476
disorder n/a 2496 2520
low_complexity n/a 2537 2547
disorder n/a 2544 2556
low_complexity n/a 2551 2564
disorder n/a 2559 2565
Pfam FATC 2596 2628

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession A4IAG3. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAETLAPNDV GGISVTKLFS SDSTAALGQQ LSSIFSNLNS TPNDRQQRAE
50
51
ECLSALTDTL FLHENELGAN ESLHERIIAL IDGTFCTSVD KGCSSFRVVF
100
101
DVKWKDQHEK RNRCFVLLLS RAFKCTTPED CLKVIQCLGE VLEDNIRTTT
150
151
DLLADNVEPL LRDLFAADVH RRTVACEVLA KIVSTTTFII KRNPTLLELL
200
201
TSSCAPLVTL KDAMETRNLW HRTALIRLTS ALVENCYEVT PAVAKDVADL
250
251
VFRYMRAAED ESQLVGVLSA LIHVAVTPAF VSAPWDLPQL VRFLCETDWS
300
301
VYAVATRVAA VAAINKVAFF FCQEEKACYE ALRTRSLEFI SLDDAVEVVT
350
351
EGLELIKEME VLERELHLGT AVVNALCACI QRLPHVPIIY ELLELIRERY
400
401
GDLEVKPIYS LLEGYLDTKQ ELLNFGKVNA LLRFAGPRIR LDDPRLAQLR
450
451
INVGANQPIP VILHSLPLLT TLQRTEQLHE VLEILSHDDR GVRRVAVSTA
500
501
LELCEIMMER NKFRNATPKG GVQRMQWLDE EVSNAVERVL DVAVADRDPE
550
551
IRLWALQHLT VPFFPYLCLC DNLDAIFMAR NDNDKATRDQ ALTLLCQLLP
600
601
YHPTVVQPQL QRAQEYMLHD VATMDASVSF AVCKAGLLKM CVDHEALLIE
650
651
KSTVEAIVLR RLEAQPFISR SLSIALLQLI RSILERTASQ HHSDFHSFLR
700
701
PLLLIVNGGD SCTRRREALE TLTAFISHIT KTDISGLSEV YRAVARIIRR
750
751
ETEEEESVTI AAMKVLSSIG AVTPVKMRHV FRMVESDEME EEEEVVTPAL
800
801
AHCKPRLRIS TDMPERYPST VLYYLVRSLQ LALDPKQQVD TLVAVRTMLH
850
851
DVEGKVKLNL LTQLLPQLQT WLRDPERAFL YETVLGLMND LAILLCQFKE
900
901
SVAPSVGHEL LRSVQAFCLL PQASQKPFSA YVVQLLDSLA KGIPAQEMRD
950
951
NRWAIEFIHQ RLSQNKNDLD LVHRVVKSLE SFIAVMHEKE LQMILPHVLQ
1000
1001
CIEPAKASPG GKLSKSKDIN DACFDFLNFV MAKQLTLVKH CCAQIVHTIM
1050
1051
WYIELADSNE EMDVGLNTLA TLVDTVKMPA KRFIMPIERV AVRNGFPPQY
1100
1101
FVNLVQSAAG GAKIRMTTSN GTGLNPDRPI TLVSHLPRLS QAEFEHEMRS
1150
1151
TPRSENVLID VLDVRHHQGQ TMIDFRFHPG TDTAACCNLF SRKATDNKSA
1200
1201
MRRNLGILRV EQTEESPRPV GADVIKALAN LPVAKTKKRE QSWVLWLHNA
1250
1251
TVTLLRNSPY AVLRDTCAVA DRNTELAKDL FPFAVAAVCG HLETPLRAQL
1300
1301
MDIFDRALAA APADVKQGLF CFAEFMESER DDDRVKLVKV MRESVFSVDR
1350
1351
ESTSQKFGIN YDQDPERGVI VTKLAPNGLG ARAGVPIGAQ LLAINDIPVR
1400
1401
AVSDIRGLIE GLTHIELLLS YEVEEKTKSK PKPLMNLEVL ASVAFSGEMH
1450
1451
IKAIYFNEVL FESLSSKICK ITDRKDSQMR RVMTIAEDLI QYYRHLNMTM
1500
1501
TANGLLKTLT RKFSDEIFAP EQFGFEEIAS LEQLNWWSEA LRRYEARMAS
1550
1551
FGARYLEVAS LVGVLRCEQA LGHSSRVQEL AEQYWEQLPV DAQREVAPFR
1600
1601
AKAAFCLGAW DTFDALALDK RMQSCFGVVE RCAALFRAEC HDELLRYTDK
1650
1651
VRESMLESFA DSLNENYNRA YEGMTRLQHL RHFEELVSFT TACEERQALL
1700
1701
KRVWHRRLVQ MSSRPDDLMT VLSINSLVLE PEDDLHSYVY VIRCLCKSQW
1750
1751
FSHAEHLLQR LLRENASLEV LCECDPELIH TYIKYVYLAK DKHGAYVELK
1800
1801
NILSAVEVDP EDPRAEMWGQ CWLLLGEWTM YLFPDCGEEA IKELMCATEL
1850
1851
GPNSAAAFHS LGILHCDLAR DPSTQGEVQN NHLICCINSL FKSIQLCNDV
1900
1901
PGSLVMQDVL RILSVWFANS SIREINEAVH HGVQVVADHV WLNVVPQLIA
1950
1951
RIGIEARYAR AILTDLLIRV GSQYSHALIY PLTVAEKSPD AVRRHMAERV
2000
2001
IMGMRNIPEN DRIVKEASLV SNEMVRIAIL WTEKWHAAIQ QAAYKPNNTA
2050
2051
AIFSMLQPLY AELDRASTPN ELSFRCNFGQ TLRRAKVALE EAKTEEAWGF
2100
2101
LRQVYAQLRR GVLERRLYMS DVSPTLDGIQ DSIVAVPGTF EHDKPLITIL
2150
2151
KFHSRVYVMP SKQKPRRIGL DASDGKKYRF LLKGHEDMRQ DERVMQFIRL
2200
2201
IDTIFQSDNA ASAIGLSIPQ YAVIPLTDNV GVVGWVENTE TIYKMLETYR
2250
2251
QAHEVSIYEE VNLIMKKGGL DTIEDYHRLP KQQRKALLNY AMENTPKNEL
2300
2301
RHIFWDHNDT CEQWLSYRQT YGQTLAAMSM VGYVLGLGDR HLNNLMLQGN
2350
2351
GTVVHIDFGD CFEVAMHRAL YAEAVPFRLT RLLVCALGIT GVDGLYRMTC
2400
2401
ELAMKNLHRH SENLLSILEA FIYDPIINWR LNTVNDVTEK SGSKSAQQES
2450
2451
SNGGTAALAG ETAAAACLGV DDAAQAEAKP VAMQLSKSVS KLVPHSALPG
2500
2501
ESQMFENGEE TRNQQGDLAL ARVQAKLTGQ DFGVVNSSFS MMRSSRRLEA
2550
2551
GGSQPQGSSW GSNSLAGFTD SPKDSFAAPL LTTYLSLRVL NGGAESLDVP
2600
2601
HQVDRLIQEA TSLDNLSDAF LTGWAPFW                        
2628
 

Show the unformatted sequence.

Checksums:
CRC64:0CD7983EC22FB245
MD5:58ef30f4782e85b867526f670e56c00a

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;