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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: D3ZTF6_RAT (D3ZTF6)

Summary

This is the summary of UniProt entry D3ZTF6_RAT (D3ZTF6).

Description: Phosphatidylinositol-4-phosphate 3-kinase {ECO:0000256|ARBA:ARBA00012013}
Source organism: Rattus norvegicus (Rat) (NCBI taxonomy ID 10116)
Length: 1687 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 3 30
low_complexity n/a 28 43
disorder n/a 32 64
disorder n/a 68 76
disorder n/a 88 91
disorder n/a 106 107
disorder n/a 109 111
disorder n/a 114 120
disorder n/a 286 287
disorder n/a 312 313
disorder n/a 317 318
disorder n/a 320 329
disorder n/a 350 364
low_complexity n/a 362 373
Pfam PI3K_rbd 411 514
disorder n/a 616 637
Pfam PI3K_C2 704 843
disorder n/a 776 784
Pfam PI3Ka 864 1047
low_complexity n/a 936 949
Pfam PI3_PI4_kinase 1133 1348
Pfam PX 1450 1535
disorder n/a 1547 1548
Pfam C2 1573 1681
low_complexity n/a 1607 1620
disorder n/a 1611 1617

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession D3ZTF6. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAQISNNSEF KQCSSSHPEP IRTKDVDKAE ALQMEAEALA KLQKDRHMTD
50
51
SPRGFELSNS TRQRTQGFNK QDYDLMVFPE SDSQKRALDI DVEKLTQAEL
100
101
EKILLDDNFE TRKTPASPVT PVLSPSFSAQ LYLRPAVQRS QWPPGLCGPS
150
151
TYTLPSIYPS AYSKQATFQN GFSPRMPTFP STESIYLRLP GQSPYFSYPL
200
201
TPATPFHPQG SLPVYRPLVS PDMAKLFDKI ASTSEFLKNG KARTDLEIAN
250
251
SKASVCNLQI SPKSEDINKF DWLDLDPLSK PKIDCVEVLE HEEEKKNPVL
300
301
LAEDPWDAVL LEERSPTSRH LERKVNGKSL SGATVTRSQS LIVRTTQVTK
350
351
AQSQVSQKDP NGTSSLATGS SLLQEFEVQN EEVAAFCQSI MKLKTKFPYT
400
401
DHCTNPGYLL SPVTVQRNMC GENASVKVSI EIEGFQQPVT FTCDVSSTVD
450
451
IIIMQALCWV HDDLNQVDVG SYILKVCGQE EVLQNNHCLG SHEHIQNCRK
500
501
WDTEIKLQLL TFSAMCQNLA RTAEDDEAPV DLNKYLYQIE KPYKEVMTRH
550
551
PVEELLDSYH YQVELALQTE NQHRAIDQVI KAVRKICSAL DGVETPAVTE
600
601
AVKKLKRAVN LPRNKSADVT SLSGGDTSKN STRGSLNLEN PVQVSMDHLT
650
651
AAIYDLLRLH TNSCKSSTVC PQGSRNIKEA WTATEQLQFT VYAAHGISSN
700
701
WVSNYEKYYL ICSLSHNGKD LFKPIQSKKV GTYKNFFYLI KWDELIIFPI
750
751
QISQLPLESV LHLTLFGVLN QSSGSSPDSN KQRKGPEALG KVSLTLFDFK
800
801
RFLTCGTKLL YLWTSSHTNS IPGAIPQKSY VMERIVLQVD FPSPAFDIIY
850
851
TSPQIDRNII QQYKLEALEN EIKGKLLDIV HRDSSFGLSK EDKAFLWEKR
900
901
YYCLKHPNCL PKILASAPNW KWANLAKTYS LLHQWPPLCP LAALELLDAK
950
951
FADQEVRSLA VSWIEAISDD ELTDLLPQFV QALKYEIYLN SSLVRFLLSR
1000
1001
ALGNIQIAHS LYWLLKDALH DTRFGSRYEH VLGALLSVGG KGLREELSKQ
1050
1051
MKLVQLLGGV AEKVRQASGS ARQVVLQKSM ERVQSFFLRN KCRVPLKPSL
1100
1101
VAKELNIKSC SFFSSNAMPL KVTMVNADPL GEEINVMFKV GEDLRQDMLA
1150
1151
LQMIKIMDKI WLKEGLDLRM VIFKCLSTGR DQGMVELVPA SDTLRKIQVE
1200
1201
YGVTGSFKDK PLAEWLRKYN PSEEEYEKAS ENFIYSCAGC CVATYVLGIC
1250
1251
DRHNDNIMLR STGHMFHIDF GKFLGHAQMF GSFKRDRAPF VLTSDMAYVI
1300
1301
NGGEKPTIRF QLFVDLCCQA YNLIRKQTNL FLNLLSLMIP SGLPELTSIQ
1350
1351
DLKYVRDALQ PQTTDAEATI FFTRLIESSL GSIATKFNFF IHNLAQLRFS
1400
1401
GLPSNDEPIL SFSPKTYSFR QDGRIKEVSV FTYHKKYNPD KHYIYVVRIL
1450
1451
REGHLEPSFV FRTFDEFQEL HNKLSIIFPL WKLPGFPNRM VLGRTHIKDV
1500
1501
AAKRKIELNS YLQSLMNAST DVAECDLVCT FFHPLLRDEK AEGIARSTGT
1550
1551
SPFSPTLGQI GGAVKLSVSY RNGTLFIMVM HIKDLVTEDG ADPNPYVKTY
1600
1601
LLPDTHKTSK RKTKISRKTR NPTFNEMLVY SGYSRETLRQ RELQLSVLSA
1650
1651
ESLRENFFLG GITLPLKDFN LSKETVKWYQ LTAATYL              
1687
 

Show the unformatted sequence.

Checksums:
CRC64:1B671E09208F3F8B
MD5:e52b65edef8a276bf20a3e6f31678345

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;