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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: F1QWN6_DANRE (F1QWN6)

Summary

This is the summary of UniProt entry F1QWN6_DANRE (F1QWN6).

Description: Phosphatidylinositol-4-phosphate 3-kinase {ECO:0000256|ARBA:ARBA00012013}
Source organism: Danio rerio (Zebrafish) (Brachydanio rerio) (NCBI taxonomy ID 7955)
Length: 1587 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 17
disorder n/a 34 112
low_complexity n/a 50 77
disorder n/a 114 116
disorder n/a 124 127
disorder n/a 130 180
low_complexity n/a 140 160
disorder n/a 185 190
disorder n/a 203 256
Pfam PI3K_rbd 311 413
low_complexity n/a 361 373
disorder n/a 418 425
disorder n/a 429 434
Pfam PI3K_C2 595 735
disorder n/a 657 659
disorder n/a 663 673
disorder n/a 707 708
disorder n/a 712 718
Pfam PI3Ka 755 937
Pfam PI3_PI4_kinase 1024 1239
low_complexity n/a 1221 1230
Pfam PX 1340 1425
disorder n/a 1433 1437
Pfam C2 1469 1578
low_complexity n/a 1504 1516
disorder n/a 1507 1515
disorder n/a 1577 1578
disorder n/a 1583 1587

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession F1QWN6. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSAAQTQNDR EQRWGCLESL GLSQKELVLA EALQMEYDAL ARHRQDKGTS
50
51
STLPPDSSKS SPSRSESSLP RRVPSPSWNN LQQQGVSGSD PMLNHVQPGV
100
101
SNLSRSSGES HGFTKEPRYI LDEWESDFKG TSQMLSKGLP TLDEPPPPVP
150
151
PRNPIPQNDP FIVHRSSAPR DVNLFTPEVD QPKLSFGETL NYDNLNDSLS
200
201
KINGDWLSPG RSRRANGDKS GKAVARSNTL PPQIPPRTYL PTPKSTRSQR
250
251
RVSVDPVSLG SRPNGFGYEL FQVSEERDEE VAAFCHVLDL LRSAYPCNDY
300
301
SKNSGFVWSP CVAQDELQQG LGVSIKVTVY SDHFREPLTF SCDGSSTIDL
350
351
LIYQTLCYAH DDLDMIDVDD YLLKICSQAE FLKNTQTLAS FEYIQQCLKF
400
401
DWDIRLILTK RSSVNMELAR TTEDDDTPST MNHSILLQER PIKQTVTKEA
450
451
LTLLLDTFHN EAESFLLSEV ELPLHVERLV QSVKALCTSL AAVETPDITA
500
501
ALNQLPACPC RLQPKVQKDV SVLAKKENRV AIVEKLTAAI LDLVELYCST
550
551
FNANFHTMPH SSRSTAPIQE AGMVTNVLSF SVYAAHRVPI TWAASYENFF
600
601
LSCSLTHGGV ELCAPQHTSK QSVSKYLFHL VVWDQRVCFP VQINQLPRES
650
651
QLTVTLYATP LPPPGGAEEK SKQKRSIESL GWVTMPLFNF RHVLTCGRKL
700
701
LGLWPSTPGS GNARSSTPNF SQPDSVILQV DFPTSSFEVR FSTPAPAEFS
750
751
PQYEFSHLDQ VSQRQLHDVL HKKSLFWLSP EDRRLLWEKR YFCHVEASRL
800
801
PLVLASAPSW EWACLPDIYA LLRQWGCMNH LDALGLLNAT FPDQECRRTA
850
851
VQWMDSISDP ELLDFLPQLV QALKYECYLD SHLVRFLLRR AIGDVRIAHY
900
901
LFWLLKDTLQ DSQFSVRYQY LLAALLCCSG RGLREEFDRQ CWLVNVLAKV
950
951
AQRVREASPS SRQAILREGL DDVKQFFSIN SSCRLPLNPG LLVKGINIQS
1000
1001
CSYFNSNAVP LKLSFQNQDH LGDNINVIFK AGDDLRQDML TLQIIRIMNK
1050
1051
IWVQEGLDMR MVIFRCFSTG RGRGMVEMIP SAETLRKIQV EHGVTGSFKD
1100
1101
RPLADWLQKH NPTEEEYEKA VENFIYSCAG CCVATYILGI CDRHNDNIML
1150
1151
KTSGHMFHID FGKFLGHAQM FGNIKRDRAP FVFTSDMAYV INGGDKPSSR
1200
1201
FHDFVDLCCE AYNRIRKHAH LFLNLLGLML SSGIPELSDV DDLKYVYDAL
1250
1251
RPHESEADAT MHFTRLIESS LGSVATKLNF FIHNLAQMKF ASSEERPVLS
1300
1301
FAPRVYTMKT DGVIRSLFVC RHIKTYSPSK GYSYVVKVER EGQQGSPTLV
1350
1351
QRTFEEFNEL HSKLQLIFPS SKLPSFPSRF VIGRSRGEAL ADRRKDELNG
1400
1401
YVWHLIHAAQ EVAQCDLIYT FFHPLPRDER AGSVGNVVNT LHKPTDVSWA
1450
1451
PVPGAMAGEV KLSVLYKSDK LFIMVMHIRG LQPLQDGTDP DPYVKLYLLP
1500
1501
DPQKTSKRKT KAARRTCNPT YNEMLVYDKI PRGDLQQRTV HLRVLSEGAF
1550
1551
WENTLLGETI IHLKDLTPGH RWVDWHQLGT RGSDTNR              
1587
 

Show the unformatted sequence.

Checksums:
CRC64:9FD525B13A4E08F7
MD5:c0242c80d4aed577187e3b6dc1ca19c0

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;