Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: F8W2C2_DANRE (F8W2C2)

Summary

This is the summary of UniProt entry F8W2C2_DANRE (F8W2C2).

Description: Phosphatidylinositol-4,5-bisphosphate 3-kinase {ECO:0000256|ARBA:ARBA00012010}
Source organism: Danio rerio (Zebrafish) (Brachydanio rerio) (NCBI taxonomy ID 7955)
Length: 1070 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam PI3K_p85B 32 107
low_complexity n/a 148 159
Pfam PI3K_rbd 173 292
low_complexity n/a 312 328
disorder n/a 313 320
Pfam PI3K_C2 352 487
disorder n/a 461 462
Pfam PI3Ka 521 705
low_complexity n/a 628 642
coiled_coil n/a 710 730
low_complexity n/a 719 734
disorder n/a 732 733
Pfam PI3_PI4_kinase 797 1016

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession F8W2C2. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAPRPSSGEL WGLHLMPPRI LVDCCLPNGI LVSLECLREA PLTSIKQQLF
50
51
SEARKYPLYH LLQEESCYIF VGVTQEAERE EFYDETRRLC DLRLFHPILK
100
101
VIEPLGNREE KILNREIGFA IGMPICEFEL VKDPEVQDFR RNILSVCREA
150
151
VEEREGGGAH TQALYVYPPN VESSPDLPQH IYSKLDKGRL IVTIWVIVSP
200
201
SNSKQKYTLK IAHDSLPEQL IAEAIRKKTR SMHLSAQQLR LCVQEYQGQY
250
251
ILKVCGCDEY FLEKYPLSQY KYIRSCITLC RLPHLMLVSK DSLYSQLPSS
300
301
GFMAPSYSRR TPQPSPCPGG GDPGSPRSLW AFNTHLRVRL LCATYVNVNI
350
351
RDIDKIYVRT GIYHGGEPLC DNVNTQRVPC SNPRWNEWLS YDIYLTDVPR
400
401
SARLCLSICS VKGRKGAKEE HCPLAWGNIN LFDYKDTLVS GKVALGLWPV
450
451
PHGLEDLLNP IGVSGSNPNK ETPCVELEFP WFNQTVVFPD EQQIEEHANW
500
501
SISRELGYSY CLGLSSRLAC DSSISQADAE QLRTLCSRDP LYELSEQEKD
550
551
FLWRHRHYCV NIPESLPKLL LSVKWNSRDE VSQIYCLLKD WPLMQPESSL
600
601
ELLDCNFPDP MVREFALRCL IQGLTDDKLS QYLLQLVQVL KYEMYLDNPL
650
651
ARFLIKKALT NQRIGHFFFW HLKSEMHNKT VSRRFGLLLE AFCRACGMYL
700
701
KHLNRQVEAM DKLVNLTDTL KQEKKDETQK TQMKFLVEHM SRPDYMEALQ
750
751
GFVSPLNPVH QLGNLRLEEC RIMSSAKRPL WLNWENPDIM SELLFTNNEI
800
801
IFKNGDDLRQ DMLTLQIIKI MENIWQNQGL DLRMLPYGCL SIGDCVGLIE
850
851
VVKNSHTIMQ IQCKGGLKGA LQFNSNTLHH WIRDRNKGEA YDRAIDLFTR
900
901
SCAGYCVATF ILGIGDRHNS NIMVKENGQL FHIDFGHFLD HKKKKFGYKR
950
951
ERVPFVLTQD FLIVISKGVQ ECTKTKEFER FQEMCYKAYL AIRQHASLFI
1000
1001
NLFSLLLGCG MPELQSFDDI AYLRKTLALE KSQQEALEYF TKQMNDAHHG
1050
1051
GWTTKMDWIF HTIRHMPNEH                                 
1070
 

Show the unformatted sequence.

Checksums:
CRC64:7AC414A3EA7B9A4A
MD5:875a82f8760ddde9a3fd84351802100a

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;