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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FOLC_MYCTU (I6Y0R5)

Summary

This is the summary of UniProt entry FOLC_MYCTU (I6Y0R5).

Description: Dihydrofolate synthase/folylpolyglutamate synthase {ECO:0000303|PubMed:23118010}
Source organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (NCBI taxonomy ID 83332)
Length: 487 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 22
disorder n/a 64 70
disorder n/a 92 108
Pfam Mur_ligase_M 140 309
low_complexity n/a 157 178
low_complexity n/a 206 220
low_complexity n/a 272 285
Pfam Mur_ligase_C 335 418
low_complexity n/a 448 460

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession I6Y0R5. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNSTNSGPPD SGSATGVVPT PDEIASLLQV EHLLDQRWPE TRIDPSLTRI
50
51
SALMDLLGSP QRSYPSIHIA GTNGKTSVAR MVDALVTALH RRTGRTTSPH
100
101
LQSPVERISI DGKPISPAQY VATYREIEPL VALIDQQSQA SAGKGGPAMS
150
151
KFEVLTAMAF AAFADAPVDV AVVEVGMGGR WDATNVINAP VAVITPISID
200
201
HVDYLGADIA GIAGEKAGII TRAPDGSPDT VAVIGRQVPK VMEVLLAESV
250
251
RADASVARED SEFAVLRRQI AVGGQVLQLQ GLGGVYSDIY LPLHGEHQAH
300
301
NAVLALASVE AFFGAGAQRQ LDGDAVRAGF AAVTSPGRLE RMRSAPTVFI
350
351
DAAHNPAGAS ALAQTLAHEF DFRFLVGVLS VLGDKDVDGI LAALEPVFDS
400
401
VVVTHNGSPR ALDVEALALA AGERFGPDRV RTAENLRDAI DVATSLVDDA
450
451
AADPDVAGDA FSRTGIVITG SVVTAGAART LFGRDPQ              
487
 

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Checksums:
CRC64:77D3A4E3D2DC59D0
MD5:1426216991eeaf159b8ec964657a0252

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;