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30  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PSD12_HUMAN (O00232)

Summary

This is the summary of UniProt entry PSD12_HUMAN (O00232).

Description: 26S proteasome non-ATPase regulatory subunit 12
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 456 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 2
coiled_coil n/a 152 172
Pfam PCI 300 417
Pfam RPN5_C 422 454

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O00232. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MADGGSERAD GRIVKMEVDY SATVDQRLPE CAKLAKEGRL QEVIETLLSL
50
51
EKQTRTASDM VSTSRILVAV VKMCYEAKEW DLLNENIMLL SKRRSQLKQA
100
101
VAKMVQQCCT YVEEITDLPI KLRLIDTLRM VTEGKIYVEI ERARLTKTLA
150
151
TIKEQNGDVK EAASILQELQ VETYGSMEKK ERVEFILEQM RLCLAVKDYI
200
201
RTQIISKKIN TKFFQEENTE KLKLKYYNLM IQLDQHEGSY LSICKHYRAI
250
251
YDTPCIQAES EKWQQALKSV VLYVILAPFD NEQSDLVHRI SGDKKLEEIP
300
301
KYKDLLKLFT TMELMRWSTL VEDYGMELRK GSLESPATDV FGSTEEGEKR
350
351
WKDLKNRVVE HNIRIMAKYY TRITMKRMAQ LLDLSVDESE AFLSNLVVNK
400
401
TIFAKVDRLA GIINFQRPKD PNNLLNDWSQ KLNSLMSLVN KTTHLIAKEE
450
451
MIHNLQ                                                
456
 

Show the unformatted sequence.

Checksums:
CRC64:97D0BDBDB0C96195
MD5:09d4286cb7bfa72f6f901e0de3b2636e

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PCI 300 - 417 5GJQ P 300 - 417 NGL View in InterPro
5GJR 3 300 - 417 NGL View in InterPro
P 300 - 417 NGL View in InterPro
5L4K P 300 - 417 NGL View in InterPro
5LN3 P 300 - 417 NGL View in InterPro
5M32 k 300 - 417 NGL View in InterPro
5T0C AW 300 - 417 NGL View in InterPro
BW 300 - 417 NGL View in InterPro
5T0G W 300 - 417 NGL View in InterPro
5T0H W 300 - 417 NGL View in InterPro
5T0I W 300 - 417 NGL View in InterPro
5T0J W 300 - 417 NGL View in InterPro
5VFP W 300 - 417 NGL View in InterPro
5VFQ W 300 - 417 NGL View in InterPro
5VFR W 300 - 417 NGL View in InterPro
5VFS W 300 - 417 NGL View in InterPro
5VFT W 300 - 417 NGL View in InterPro
5VFU W 300 - 417 NGL View in InterPro
5VGZ W 300 - 417 NGL View in InterPro
5VHF W 300 - 417 NGL View in InterPro
5VHH W 300 - 417 NGL View in InterPro
5VHI W 300 - 417 NGL View in InterPro
5VHS W 300 - 417 NGL View in InterPro
6MSB W 300 - 417 NGL View in InterPro
6MSD W 300 - 417 NGL View in InterPro
6MSE W 300 - 417 NGL View in InterPro
6MSG W 300 - 417 NGL View in InterPro
6MSH W 300 - 417 NGL View in InterPro
6MSJ W 300 - 417 NGL View in InterPro
6MSK W 300 - 417 NGL View in InterPro
6WJD W 300 - 417 NGL View in InterPro
6WJN W 300 - 417 NGL View in InterPro
RPN5_C 422 - 454 5GJQ P 422 - 454 NGL View in InterPro
5GJR 3 422 - 454 NGL View in InterPro
P 422 - 454 NGL View in InterPro
5L4K P 422 - 454 NGL View in InterPro
5LN3 P 422 - 454 NGL View in InterPro
5M32 k 422 - 454 NGL View in InterPro
5T0C AW 422 - 454 NGL View in InterPro
BW 422 - 454 NGL View in InterPro
5T0G W 422 - 454 NGL View in InterPro
5T0H W 422 - 454 NGL View in InterPro
5T0I W 422 - 454 NGL View in InterPro
5T0J W 422 - 454 NGL View in InterPro
5VFP W 422 - 454 NGL View in InterPro
5VFQ W 422 - 454 NGL View in InterPro
5VFR W 422 - 454 NGL View in InterPro
5VFS W 422 - 454 NGL View in InterPro
5VFT W 422 - 454 NGL View in InterPro
5VFU W 422 - 454 NGL View in InterPro
5VGZ W 422 - 454 NGL View in InterPro
5VHF W 422 - 454 NGL View in InterPro
5VHH W 422 - 454 NGL View in InterPro
5VHI W 422 - 454 NGL View in InterPro
5VHS W 422 - 454 NGL View in InterPro
6MSB W 422 - 454 NGL View in InterPro
6MSD W 422 - 454 NGL View in InterPro
6MSE W 422 - 454 NGL View in InterPro
6MSG W 422 - 454 NGL View in InterPro
6MSH W 422 - 454 NGL View in InterPro
6MSJ W 422 - 454 NGL View in InterPro
6MSK W 422 - 454 NGL View in InterPro
6WJD W 422 - 454 NGL View in InterPro
6WJN W 422 - 454 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;