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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: BCL9_HUMAN (O00512)

Summary

This is the summary of UniProt entry BCL9_HUMAN (O00512).

Description: B-cell CLL/lymphoma 9 protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1426 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 479
low_complexity n/a 47 62
low_complexity n/a 86 98
low_complexity n/a 229 247
low_complexity n/a 256 273
low_complexity n/a 321 342
Pfam BCL9 350 388
disorder n/a 481 1014
low_complexity n/a 481 494
low_complexity n/a 506 517
low_complexity n/a 818 836
low_complexity n/a 892 903
disorder n/a 1016 1017
disorder n/a 1019 1376
low_complexity n/a 1033 1045
low_complexity n/a 1136 1154
low_complexity n/a 1157 1178
low_complexity n/a 1258 1269
low_complexity n/a 1282 1300
low_complexity n/a 1372 1392
disorder n/a 1379 1426

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O00512. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MHSSNPKVRS SPSGNTQSSP KSKQEVMVRP PTVMSPSGNP QLDSKFSNQG
50
51
KQGGSASQSQ PSPCDSKSGG HTPKALPGPG GSMGLKNGAG NGAKGKGKRE
100
101
RSISADSFDQ RDPGTPNDDS DIKECNSADH IKSQDSQHTP HSMTPSNATA
150
151
PRSSTPSHGQ TTATEPTPAQ KTPAKVVYVF STEMANKAAE AVLKGQVETI
200
201
VSFHIQNISN NKTERSTAPL NTQISALRND PKPLPQQPPA PANQDQNSSQ
250
251
NTRLQPTPPI PAPAPKPAAP PRPLDRESPG VENKLIPSVG SPASSTPLPP
300
301
DGTGPNSTPN NRAVTPVSQG SNSSSADPKA PPPPPVSSGE PPTLGENPDG
350
351
LSQEQLEHRE RSLQTLRDIQ RMLFPDEKEF TGAQSGGPQQ NPGVLDGPQK
400
401
KPEGPIQAMM AQSQSLGKGP GPRTDVGAPF GPQGHRDVPF SPDEMVPPSM
450
451
NSQSGTIGPD HLDHMTPEQI AWLKLQQEFY EEKRRKQEQV VVQQCSLQDM
500
501
MVHQHGPRGV VRGPPPPYQM TPSEGWAPGG TEPFSDGINM PHSLPPRGMA
550
551
PHPNMPGSQM RLPGFAGMIN SEMEGPNVPN PASRPGLSGV SWPDDVPKIP
600
601
DGRNFPPGQG IFSGPGRGER FPNPQGLSEE MFQQQLAEKQ LGLPPGMAME
650
651
GIRPSMEMNR MIPGSQRHME PGNNPIFPRI PVEGPLSPSR GDFPKGIPPQ
700
701
MGPGRELEFG MVPSGMKGDV NLNVNMGSNS QMIPQKMREA GAGPEEMLKL
750
751
RPGGSDMLPA QQKMVPLPFG EHPQQEYGMG PRPFLPMSQG PGSNSGLRNL
800
801
REPIGPDQRT NSRLSHMPPL PLNPSSNPTS LNTAPPVQRG LGRKPLDISV
850
851
AGSQVHSPGI NPLKSPTMHQ VQSPMLGSPS GNLKSPQTPS QLAGMLAGPA
900
901
AAASIKSPPV LGSAAASPVH LKSPSLPAPS PGWTSSPKPP LQSPGIPPNH
950
951
KAPLTMASPA MLGNVESGGP PPPTASQPAS VNIPGSLPSS TPYTMPPEPT
1000
1001
LSQNPLSIMM SRMSKFAMPS STPLYHDAIK TVASSDDDSP PARSPNLPSM
1050
1051
NNMPGMGINT QNPRISGPNP VVPMPTLSPM GMTQPLSHSN QMPSPNAVGP
1100
1101
NIPPHGVPMG PGLMSHNPIM GHGSQEPPMV PQGRMGFPQG FPPVQSPPQQ
1150
1151
VPFPHNGPSG GQGSFPGGMG FPGEGPLGRP SNLPQSSADA ALCKPGGPGG
1200
1201
PDSFTVLGNS MPSVFTDPDL QEVIRPGATG IPEFDLSRII PSEKPSQTLQ
1250
1251
YFPRGEVPGR KQPQGPGPGF SHMQGMMGEQ APRMGLALPG MGGPGPVGTP
1300
1301
DIPLGTAPSM PGHNPMRPPA FLQQGMMGPH HRMMSPAQST MPGQPTLMSN
1350
1351
PAAAVGMIPG KDRGPAGLYT HPGPVGSPGM MMSMQGMMGP QQNIMIPPQM
1400
1401
RPRGMAADVG MGGFSQGPGN PGNMMF                          
1426
 

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Checksums:
CRC64:51EF3D0DCA2103CB
MD5:5dffe3e74bec9adbc692dcd4ef3e696a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
BCL9 350 - 374 3SL9 C 350 - 374 NGL View in InterPro
350 - 375 3SL9 F 350 - 375 NGL View in InterPro
352 - 371 3SL9 H 352 - 371 NGL View in InterPro
352 - 374 2GL7 C 352 - 374 NGL View in InterPro
3SL9 D 352 - 374 NGL View in InterPro
355 - 371 2GL7 F 355 - 371 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.