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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: CAC1A_HUMAN (O00555)

Summary

This is the summary of UniProt entry CAC1A_HUMAN (O00555).

Description: Voltage-dependent P/Q-type calcium channel subunit alpha-1A {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 2506 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
low_complexity n/a 13 46
disorder n/a 30 49
Pfam Ion_trans 97 371
transmembrane n/a 102 119
disorder n/a 126 128
transmembrane n/a 139 159
transmembrane n/a 171 189
transmembrane n/a 222 245
low_complexity n/a 226 245
disorder n/a 266 279
disorder n/a 283 286
transmembrane n/a 304 325
transmembrane n/a 337 359
coiled_coil n/a 367 387
Pfam Ion_trans 485 724
transmembrane n/a 487 506
transmembrane n/a 518 538
transmembrane n/a 550 570
transmembrane n/a 576 593
low_complexity n/a 598 609
low_complexity n/a 612 630
transmembrane n/a 613 635
transmembrane n/a 689 713
coiled_coil n/a 709 745
low_complexity n/a 719 740
disorder n/a 722 739
low_complexity n/a 732 743
disorder n/a 756 762
disorder n/a 764 781
disorder n/a 785 794
disorder n/a 798 1220
low_complexity n/a 935 950
low_complexity n/a 980 1011
low_complexity n/a 1018 1031
low_complexity n/a 1121 1140
low_complexity n/a 1191 1216
Pfam Ion_trans 1242 1520
transmembrane n/a 1242 1261
transmembrane n/a 1281 1302
transmembrane n/a 1314 1331
transmembrane n/a 1376 1398
transmembrane n/a 1488 1513
low_complexity n/a 1488 1506
Pfam Ion_trans 1564 1821
transmembrane n/a 1569 1587
transmembrane n/a 1599 1622
transmembrane n/a 1628 1646
low_complexity n/a 1656 1672
transmembrane n/a 1667 1684
transmembrane n/a 1690 1708
low_complexity n/a 1719 1729
transmembrane n/a 1786 1810
Pfam GPHH 1830 1883
Pfam Ca_chan_IQ 1893 1970
disorder n/a 1971 2506
low_complexity n/a 2102 2111
low_complexity n/a 2150 2166
low_complexity n/a 2210 2223
low_complexity n/a 2261 2284
low_complexity n/a 2313 2325
low_complexity n/a 2416 2436

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O00555. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MARFGDEMPA RYGGGGSGAA AGVVVGSGGG RGAGGSRQGG QPGAQRMYKQ
50
51
SMAQRARTMA LYNPIPVRQN CLTVNRSLFL FSEDNVVRKY AKKITEWPPF
100
101
EYMILATIIA NCIVLALEQH LPDDDKTPMS ERLDDTEPYF IGIFCFEAGI
150
151
KIIALGFAFH KGSYLRNGWN VMDFVVVLTG ILATVGTEFD LRTLRAVRVL
200
201
RPLKLVSGIP SLQVVLKSIM KAMIPLLQIG LLLFFAILIF AIIGLEFYMG
250
251
KFHTTCFEEG TDDIQGESPA PCGTEEPART CPNGTKCQPY WEGPNNGITQ
300
301
FDNILFAVLT VFQCITMEGW TDLLYNSNDA SGNTWNWLYF IPLIIIGSFF
350
351
MLNLVLGVLS GEFAKERERV ENRRAFLKLR RQQQIERELN GYMEWISKAE
400
401
EVILAEDETD GEQRHPFDAL RRTTIKKSKT DLLNPEEAED QLADIASVGS
450
451
PFARASIKSA KLENSTFFHK KERRMRFYIR RMVKTQAFYW TVLSLVALNT
500
501
LCVAIVHYNQ PEWLSDFLYY AEFIFLGLFM SEMFIKMYGL GTRPYFHSSF
550
551
NCFDCGVIIG SIFEVIWAVI KPGTSFGISV LRALRLLRIF KVTKYWASLR
600
601
NLVVSLLNSM KSIISLLFLL FLFIVVFALL GMQLFGGQFN FDEGTPPTNF
650
651
DTFPAAIMTV FQILTGEDWN EVMYDGIKSQ GGVQGGMVFS IYFIVLTLFG
700
701
NYTLLNVFLA IAVDNLANAQ ELTKDEQEEE EAANQKLALQ KAKEVAEVSP
750
751
LSAANMSIAV KEQQKNQKPA KSVWEQRTSE MRKQNLLASR EALYNEMDPD
800
801
ERWKAAYTRH LRPDMKTHLD RPLVVDPQEN RNNNTNKSRA AEPTVDQRLG
850
851
QQRAEDFLRK QARYHDRARD PSGSAGLDAR RPWAGSQEAE LSREGPYGRE
900
901
SDHHAREGSL EQPGFWEGEA ERGKAGDPHR RHVHRQGGSR ESRSGSPRTG
950
951
ADGEHRRHRA HRRPGEEGPE DKAERRARHR EGSRPARGGE GEGEGPDGGE
1000
1001
RRRRHRHGAP ATYEGDARRE DKERRHRRRK ENQGSGVPVS GPNLSTTRPI
1050
1051
QQDLGRQDPP LAEDIDNMKN NKLATAESAA PHGSLGHAGL PQSPAKMGNS
1100
1101
TDPGPMLAIP AMATNPQNAA SRRTPNNPGN PSNPGPPKTP ENSLIVTNPS
1150
1151
GTQTNSAKTA RKPDHTTVDI PPACPPPLNH TVVQVNKNAN PDPLPKKEEE
1200
1201
KKEEEEDDRG EDGPKPMPPY SSMFILSTTN PLRRLCHYIL NLRYFEMCIL
1250
1251
MVIAMSSIAL AAEDPVQPNA PRNNVLRYFD YVFTGVFTFE MVIKMIDLGL
1300
1301
VLHQGAYFRD LWNILDFIVV SGALVAFAFT GNSKGKDINT IKSLRVLRVL
1350
1351
RPLKTIKRLP KLKAVFDCVV NSLKNVFNIL IVYMLFMFIF AVVAVQLFKG
1400
1401
KFFHCTDESK EFEKDCRGKY LLYEKNEVKA RDREWKKYEF HYDNVLWALL
1450
1451
TLFTVSTGEG WPQVLKHSVD ATFENQGPSP GYRMEMSIFY VVYFVVFPFF
1500
1501
FVNIFVALII ITFQEQGDKM MEEYSLEKNE RACIDFAISA KPLTRHMPQN
1550
1551
KQSFQYRMWQ FVVSPPFEYT IMAMIALNTI VLMMKFYGAS VAYENALRVF
1600
1601
NIVFTSLFSL ECVLKVMAFG ILNYFRDAWN IFDFVTVLGS ITDILVTEFG
1650
1651
NNFINLSFLR LFRAARLIKL LRQGYTIRIL LWTFVQSFKA LPYVCLLIAM
1700
1701
LFFIYAIIGM QVFGNIGIDV EDEDSDEDEF QITEHNNFRT FFQALMLLFR
1750
1751
SATGEAWHNI MLSCLSGKPC DKNSGILTRE CGNEFAYFYF VSFIFLCSFL
1800
1801
MLNLFVAVIM DNFEYLTRDS SILGPHHLDE YVRVWAEYDP AAWGRMPYLD
1850
1851
MYQMLRHMSP PLGLGKKCPA RVAYKRLLRM DLPVADDNTV HFNSTLMALI
1900
1901
RTALDIKIAK GGADKQQMDA ELRKEMMAIW PNLSQKTLDL LVTPHKSTDL
1950
1951
TVGKIYAAMM IMEYYRQSKA KKLQAMREEQ DRTPLMFQRM EPPSPTQEGG
2000
2001
PGQNALPSTQ LDPGGALMAH ESGLKESPSW VTQRAQEMFQ KTGTWSPEQG
2050
2051
PPTDMPNSQP NSQSVEMREM GRDGYSDSEH YLPMEGQGRA ASMPRLPAEN
2100
2101
QRRRGRPRGN NLSTISDTSP MKRSASVLGP KARRLDDYSL ERVPPEENQR
2150
2151
HHQRRRDRSH RASERSLGRY TDVDTGLGTD LSMTTQSGDL PSKERDQERG
2200
2201
RPKDRKHRQH HHHHHHHHHP PPPDKDRYAQ ERPDHGRARA RDQRWSRSPS
2250
2251
EGREHMAHRQ GSSSVSGSPA PSTSGTSTPR RGRRQLPQTP STPRPHVSYS
2300
2301
PVIRKAGGSG PPQQQQQQQQ QQQQQAVARP GRAATSGPRR YPGPTAEPLA
2350
2351
GDRPPTGGHS SGRSPRMERR VPGPARSESP RACRHGGARW PASGPHVSEG
2400
2401
PPGPRHHGYY RGSDYDEADG PGSGGGEEAM AGAYDAPPPV RHASSGATGR
2450
2451
SPRTPRASGP ACASPSRHGR RLPNGYYPAH GLARPRGPGS RKGLHEPYSE
2500
2501
SDDDWC                                                
2506
 

Show the unformatted sequence.

Checksums:
CRC64:AEDF4D2A5E49263F
MD5:8da1185e268c4e129e18b3a054514a02

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Ca_chan_IQ 1954 - 1970 3BXK B 1960 - 1976 Show 3D Structure View in InterPro
D 1960 - 1976 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;