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10  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: IMA3_HUMAN (O00629)

Summary

This is the summary of UniProt entry IMA3_HUMAN (O00629).

Description: Importin subunit alpha-3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 521 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 24
Pfam IBB 11 93
disorder n/a 26 34
disorder n/a 43 45
disorder n/a 47 50
disorder n/a 52 54
disorder n/a 57 62
disorder n/a 73 75
Pfam Arm 103 144
Pfam Arm 146 186
Pfam Arm 188 229
Pfam Arm 232 271
Pfam Arm 273 313
Pfam Arm 315 355
Pfam Arm 357 397
Pfam Arm 400 440
Pfam Arm_3 447 499
low_complexity n/a 479 493

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O00629. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MADNEKLDNQ RLKNFKNKGR DLETMRRQRN EVVVELRKNK RDEHLLKRRN
50
51
VPHEDICEDS DIDGDYRVQN TSLEAIVQNA SSDNQGIQLS AVQAARKLLS
100
101
SDRNPPIDDL IKSGILPILV HCLERDDNPS LQFEAAWALT NIASGTSEQT
150
151
QAVVQSNAVP LFLRLLHSPH QNVCEQAVWA LGNIIGDGPQ CRDYVISLGV
200
201
VKPLLSFISP SIPITFLRNV TWVMVNLCRH KDPPPPMETI QEILPALCVL
250
251
IHHTDVNILV DTVWALSYLT DAGNEQIQMV IDSGIVPHLV PLLSHQEVKV
300
301
QTAALRAVGN IVTGTDEQTQ VVLNCDALSH FPALLTHPKE KINKEAVWFL
350
351
SNITAGNQQQ VQAVIDANLV PMIIHLLDKG DFGTQKEAAW AISNLTISGR
400
401
KDQVAYLIQQ NVIPPFCNLL TVKDAQVVQV VLDGLSNILK MAEDEAETIG
450
451
NLIEECGGLE KIEQLQNHEN EDIYKLAYEI IDQFFSSDDI DEDPSLVPEA
500
501
IQGGTFGFNS SANVPTEGFQ F                               
521
 

Show the unformatted sequence.

Checksums:
CRC64:D98BC45002C9F57E
MD5:4337049a43c9f2b24e03a5d3eb5f2f3d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Arm 103 - 144 4UAE A 103 - 144 NGL View in InterPro
5TBK A 103 - 144 NGL View in InterPro
B 103 - 144 NGL View in InterPro
C 103 - 144 NGL View in InterPro
D 103 - 144 NGL View in InterPro
E 103 - 144 NGL View in InterPro
F 103 - 144 NGL View in InterPro
G 103 - 144 NGL View in InterPro
H 103 - 144 NGL View in InterPro
5XZX A 103 - 144 NGL View in InterPro
6BVV A 103 - 144 NGL View in InterPro
6BVZ A 103 - 144 NGL View in InterPro
6BW9 A 103 - 144 NGL View in InterPro
6BWA A 103 - 144 NGL View in InterPro
6BWB A 103 - 144 NGL View in InterPro
6WX8 A 103 - 144 NGL View in InterPro
C 103 - 144 NGL View in InterPro
7JJL A 103 - 144 NGL View in InterPro
146 - 186 4UAE A 146 - 186 NGL View in InterPro
5TBK A 146 - 186 NGL View in InterPro
B 146 - 186 NGL View in InterPro
C 146 - 186 NGL View in InterPro
D 146 - 186 NGL View in InterPro
E 146 - 186 NGL View in InterPro
F 146 - 186 NGL View in InterPro
G 146 - 186 NGL View in InterPro
H 146 - 186 NGL View in InterPro
5XZX A 146 - 186 NGL View in InterPro
6BVV A 146 - 186 NGL View in InterPro
6BVZ A 146 - 186 NGL View in InterPro
6BW9 A 146 - 186 NGL View in InterPro
6BWA A 146 - 186 NGL View in InterPro
6BWB A 146 - 186 NGL View in InterPro
6WX8 A 146 - 186 NGL View in InterPro
C 146 - 186 NGL View in InterPro
7JJL A 146 - 186 NGL View in InterPro
188 - 229 4UAE A 188 - 229 NGL View in InterPro
5TBK A 188 - 229 NGL View in InterPro
B 188 - 229 NGL View in InterPro
C 188 - 229 NGL View in InterPro
D 188 - 229 NGL View in InterPro
E 188 - 229 NGL View in InterPro
F 188 - 229 NGL View in InterPro
G 188 - 229 NGL View in InterPro
H 188 - 229 NGL View in InterPro
5XZX A 188 - 229 NGL View in InterPro
6BVV A 188 - 229 NGL View in InterPro
6BVZ A 188 - 229 NGL View in InterPro
6BW9 A 188 - 229 NGL View in InterPro
6BWA A 188 - 229 NGL View in InterPro
6BWB A 188 - 229 NGL View in InterPro
6WX8 A 188 - 229 NGL View in InterPro
C 188 - 229 NGL View in InterPro
7JJL A 188 - 229 NGL View in InterPro
232 - 271 4UAE A 232 - 271 NGL View in InterPro
5TBK A 232 - 271 NGL View in InterPro
B 232 - 271 NGL View in InterPro
C 232 - 271 NGL View in InterPro
D 232 - 271 NGL View in InterPro
E 232 - 271 NGL View in InterPro
F 232 - 271 NGL View in InterPro
G 232 - 271 NGL View in InterPro
H 232 - 271 NGL View in InterPro
5XZX A 232 - 271 NGL View in InterPro
6BVV A 232 - 271 NGL View in InterPro
6BVZ A 232 - 271 NGL View in InterPro
6BW9 A 232 - 271 NGL View in InterPro
6BWA A 232 - 271 NGL View in InterPro
6BWB A 232 - 271 NGL View in InterPro
6WX8 A 232 - 271 NGL View in InterPro
C 232 - 271 NGL View in InterPro
7JJL A 232 - 271 NGL View in InterPro
273 - 313 4UAE A 273 - 313 NGL View in InterPro
5TBK A 273 - 313 NGL View in InterPro
B 273 - 313 NGL View in InterPro
C 273 - 313 NGL View in InterPro
D 273 - 313 NGL View in InterPro
E 273 - 313 NGL View in InterPro
F 273 - 313 NGL View in InterPro
G 273 - 313 NGL View in InterPro
H 273 - 313 NGL View in InterPro
5XZX A 273 - 313 NGL View in InterPro
6BVV A 273 - 313 NGL View in InterPro
6BVZ A 273 - 313 NGL View in InterPro
6BW9 A 273 - 313 NGL View in InterPro
6BWA A 273 - 313 NGL View in InterPro
6BWB A 273 - 313 NGL View in InterPro
6WX8 A 273 - 313 NGL View in InterPro
C 273 - 313 NGL View in InterPro
7JJL A 273 - 313 NGL View in InterPro
315 - 355 4UAE A 315 - 355 NGL View in InterPro
5TBK A 315 - 355 NGL View in InterPro
B 315 - 355 NGL View in InterPro
C 315 - 355 NGL View in InterPro
D 315 - 355 NGL View in InterPro
E 315 - 355 NGL View in InterPro
F 315 - 355 NGL View in InterPro
G 315 - 355 NGL View in InterPro
H 315 - 355 NGL View in InterPro
5XZX A 315 - 355 NGL View in InterPro
6BVV A 315 - 355 NGL View in InterPro
6BVZ A 315 - 355 NGL View in InterPro
6BW9 A 315 - 355 NGL View in InterPro
6BWA A 315 - 355 NGL View in InterPro
6BWB A 315 - 355 NGL View in InterPro
6WX8 A 315 - 355 NGL View in InterPro
C 315 - 355 NGL View in InterPro
7JJL A 315 - 355 NGL View in InterPro
357 - 397 4UAE A 357 - 397 NGL View in InterPro
5TBK A 357 - 397 NGL View in InterPro
B 357 - 397 NGL View in InterPro
C 357 - 397 NGL View in InterPro
D 357 - 397 NGL View in InterPro
E 357 - 397 NGL View in InterPro
F 357 - 397 NGL View in InterPro
G 357 - 397 NGL View in InterPro
H 357 - 397 NGL View in InterPro
5XZX A 357 - 397 NGL View in InterPro
6BVV A 357 - 397 NGL View in InterPro
6BVZ A 357 - 397 NGL View in InterPro
6BW9 A 357 - 397 NGL View in InterPro
6BWA A 357 - 397 NGL View in InterPro
6BWB A 357 - 397 NGL View in InterPro
6WX8 A 357 - 397 NGL View in InterPro
C 357 - 397 NGL View in InterPro
7JJL A 357 - 397 NGL View in InterPro
400 - 440 4UAE A 400 - 440 NGL View in InterPro
5TBK A 400 - 440 NGL View in InterPro
B 400 - 440 NGL View in InterPro
C 400 - 440 NGL View in InterPro
D 400 - 440 NGL View in InterPro
E 400 - 440 NGL View in InterPro
F 400 - 440 NGL View in InterPro
G 400 - 440 NGL View in InterPro
H 400 - 440 NGL View in InterPro
5XZX A 400 - 440 NGL View in InterPro
6BVV A 400 - 440 NGL View in InterPro
6BVZ A 400 - 440 NGL View in InterPro
6BW9 A 400 - 440 NGL View in InterPro
6BWA A 400 - 440 NGL View in InterPro
6BWB A 400 - 440 NGL View in InterPro
6WX8 A 400 - 440 NGL View in InterPro
C 400 - 440 NGL View in InterPro
7JJL A 400 - 440 NGL View in InterPro
Arm_3 447 - 483 7JJL A 447 - 483 NGL View in InterPro
447 - 485 5XZX A 447 - 485 NGL View in InterPro
6WX8 A 447 - 485 NGL View in InterPro
447 - 486 5TBK B 447 - 486 NGL View in InterPro
D 447 - 486 NGL View in InterPro
E 447 - 486 NGL View in InterPro
F 447 - 486 NGL View in InterPro
6BVZ A 447 - 486 NGL View in InterPro
6WX8 C 447 - 486 NGL View in InterPro
447 - 487 4UAE A 447 - 487 NGL View in InterPro
5TBK A 447 - 487 NGL View in InterPro
C 447 - 487 NGL View in InterPro
G 447 - 487 NGL View in InterPro
H 447 - 487 NGL View in InterPro
6BVV A 447 - 487 NGL View in InterPro
6BW9 A 447 - 487 NGL View in InterPro
6BWA A 447 - 487 NGL View in InterPro
6BWB A 447 - 487 NGL View in InterPro
IBB 67 - 93 6WX8 A 67 - 93 NGL View in InterPro
70 - 93 6WX8 C 70 - 93 NGL View in InterPro
71 - 93 4UAE A 71 - 93 NGL View in InterPro
5TBK A 71 - 93 NGL View in InterPro
C 71 - 93 NGL View in InterPro
E 71 - 93 NGL View in InterPro
F 71 - 93 NGL View in InterPro
G 71 - 93 NGL View in InterPro
H 71 - 93 NGL View in InterPro
72 - 93 5TBK B 72 - 93 NGL View in InterPro
D 72 - 93 NGL View in InterPro
5XZX A 72 - 93 NGL View in InterPro
6BVV A 72 - 93 NGL View in InterPro
6BVZ A 72 - 93 NGL View in InterPro
6BW9 A 72 - 93 NGL View in InterPro
6BWA A 72 - 93 NGL View in InterPro
6BWB A 72 - 93 NGL View in InterPro
7JJL A 72 - 93 NGL View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;