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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SCN9A_RAT (O08562)

Summary

This is the summary of UniProt entry SCN9A_RAT (O08562).

Description: Sodium channel protein type 9 subunit alpha {ECO:0000250|UniProtKB:Q15858}
Source organism: Rattus norvegicus (Rat) (NCBI taxonomy ID 10116)
Length: 1984 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 3
disorder n/a 7 8
coiled_coil n/a 25 45
disorder n/a 26 51
low_complexity n/a 29 45
transmembrane n/a 122 145
Pfam Ion_trans 125 412
transmembrane n/a 190 209
transmembrane n/a 221 242
transmembrane n/a 248 268
coiled_coil n/a 276 296
low_complexity n/a 294 307
transmembrane n/a 339 358
transmembrane n/a 378 405
coiled_coil n/a 402 443
low_complexity n/a 433 446
low_complexity n/a 458 472
disorder n/a 461 542
low_complexity n/a 469 493
Pfam Na_trans_cytopl 534 693
disorder n/a 554 557
disorder n/a 564 565
disorder n/a 567 576
disorder n/a 580 617
disorder n/a 649 651
disorder n/a 654 656
disorder n/a 658 661
coiled_coil n/a 685 705
transmembrane n/a 712 730
transmembrane n/a 736 762
Pfam Ion_trans 742 977
transmembrane n/a 774 792
transmembrane n/a 812 833
low_complexity n/a 830 842
transmembrane n/a 854 882
low_complexity n/a 870 882
transmembrane n/a 912 932
transmembrane n/a 944 967
low_complexity n/a 956 975
Pfam Na_trans_assoc 981 1185
disorder n/a 1019 1040
disorder n/a 1090 1093
disorder n/a 1095 1145
low_complexity n/a 1106 1114
low_complexity n/a 1114 1127
low_complexity n/a 1132 1151
Pfam Ion_trans 1189 1466
transmembrane n/a 1191 1209
low_complexity n/a 1212 1223
transmembrane n/a 1230 1246
transmembrane n/a 1258 1278
low_complexity n/a 1286 1301
transmembrane n/a 1307 1333
low_complexity n/a 1430 1445
transmembrane n/a 1432 1455
Pfam Ion_trans 1512 1769
transmembrane n/a 1514 1532
transmembrane n/a 1544 1562
transmembrane n/a 1574 1594
transmembrane n/a 1600 1619
low_complexity n/a 1610 1622
transmembrane n/a 1631 1659
disorder n/a 1720 1721
transmembrane n/a 1735 1758
low_complexity n/a 1735 1746
disorder n/a 1858 1863
disorder n/a 1868 1870
disorder n/a 1876 1880
disorder n/a 1914 1984
low_complexity n/a 1965 1981

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O08562. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAMLPPPGPQ SFVHFTKQSL ALIEQRISEE KAKEHKDEKK DDEEEGPKPS
50
51
SDLEAGKQLP FIYGDIPPGM VSEPLEDLDP YYADKKTFIV LNKGKAIFRF
100
101
NATPALYMLS PFSPLRRISI KILVHSLFSM LIMCTILTNC IFMTLSNPPE
150
151
WTKNVEYTFT GIYTFESLIK ILARGFCVGE FTFLRDPWNW LDFVVIVFAY
200
201
LTEFVNLGNV SALRTFRVLR ALKTISVIPG LKTIVGALIQ SVKKLSDVMI
250
251
LTVFCLSVFA LIGLQLFMGN LKHKCFRKEL EENETLESIM NTAESEEELK
300
301
KYFYYLEGSK DALLCGFSTD SGQCPEGYIC VKAGRNPDYG YTSFDTFSWA
350
351
FLALFRLMTQ DYWENLYQQT LRAAGKTYMI FFVVVIFLGS FYLINLILAV
400
401
VAMAYEEQNQ ANIEEAKQKE LEFQQMLDRL KKEQEEAEAI AAAAAEFTSI
450
451
GRSRIMGLSE SSSETSRLSS KSAKERRNRR KKKKQKMSSG EEKGDDEKLS
500
501
KSGSEESIRK KSFHLGVEGH HRTREKRLST PNQSPLSIRG SLFSARRSSR
550
551
TSLFSFKGRG RDLGSETEFA DDEHSIFGDN ESRRGSLFVP HRPRERRSSN
600
601
ISQASRSPPV LPVNGKMHSA VDCNGVVSLV DGPSALMLPN GQLLPEVIID
650
651
KATSDDSGTT NQMRKKRLSS SYFLSEDMLN DPHLRQRAMS RASILTNTVE
700
701
ELEESRQKCP PWWYRFAHTF LIWNCSPYWI KFKKLIYFIV MDPFVDLAIT
750
751
ICIVLNTLFM AMEHHPMTEE FKNVLAVGNL IFTGIFAAEM VLKLIAMDPY
800
801
EYFQVGWNIF DSLIVTLSLI ELFLADVEGL SVLRSFRLLR VFKLAKSWPT
850
851
LNMLIKIIGN SVGALGNLTL VLAIIVFIFA VVGMQLFGKS YKECVCKINV
900
901
DCKLPRWHMN DFFHSFLIVF RVLCGEWIET MWDCMEVAGQ TMCLIVYMMV
950
951
MVIGNLVVLN LFLALLLSSF SSDNLTAIEE DTDANNLQIA VARIKRGINY
1000
1001
VKQTLREFIL KSFSKKPKGS KDTKRTADPN NKKENYISNR TLAEMSKDHN
1050
1051
FLKEKDRISG YGSSLDKSFM DENDYQSFIH NPSLTVTVPI APGESDLEIM
1100
1101
NTEELSSDSD SDYSKEKRNR SSSSECSTVD NPLPGEEEAE AEPVNADEPE
1150
1151
ACFTDGCVRR FPCCQVNVDS GKGKVWWTIR KTCYRIVEHS WFESFIVLMI
1200
1201
LLSSGALAFE DIYIEKKKTI KIILEYADKI FTYIFILEML LKWVAYGYKT
1250
1251
YFTNAWCWLD FLIVDVSLVT LVANTLGYSD LGPIKSLRTL RALRPLRALS
1300
1301
RFEGMRVVVN ALIGAIPSIM NVLLVCLIFW LIFSIMGVNL FAGKFYECVN
1350
1351
TTDGSRFPTS QVANRSECFA LMNVSGNVRW KNLKVNFDNV GLGYLSLLQV
1400
1401
ATFKGWMDIM YAAVDSVNVN EQPKYEYSLY MYIYFVIFII FGSFFTLNLF
1450
1451
IGVIIDNFNQ QKKKLGGQDI FMTEEQKKYY NAMKKLGSKK PQKPIPRPGN
1500
1501
KFQGCIFDLV TNQAFDITIM VLICLNMVTM MVEKEGQTEY MDYVLHWINM
1550
1551
VFIILFTGEC VLKLISLRHY YFTVGWNIFD FVVVILSIVG MFLAEMIEKY
1600
1601
FVSPTLFRVI RLARIGRILR LIKGAKGIRT LLFALMMSLP ALFNIGLLLF
1650
1651
LVMFIYAIFG MSNFAYVKKE AGINDMFNFE TFGNSMICLF QITTSAGWDG
1700
1701
LLAPILNSAP PDCDPKKVHP GSSVEGDCGN PSVGIFYFVS YIIISFLVVV
1750
1751
NMYIAVILEN FSVATEESTE PLSEDDFEMF YEVWEKFDPD ATQFIEFCKL
1800
1801
SDFAAALDPP LLIAKPNKVQ LIAMDLPMVS GDRIHCLDIL FAFTKRVLGE
1850
1851
GGEMDSLRSQ MEERFMSANP SKVSYEPITT TLKRKQEEVS ATIIQRAYRR
1900
1901
YRLRQHVKNI SSIYIKDGDR DDDLPNKEDT VFDNVNENSS PEKTDVTAST
1950
1951
ISPPSYDSVT KPDQEKYETD KTEKEDKEKD ESRK                 
1984
 

Show the unformatted sequence.

Checksums:
CRC64:386C38B9B5097091
MD5:6ae438ded4944885924e989f79960cbb

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;