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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SPTN2_HUMAN (O15020)

Summary

This is the summary of UniProt entry SPTN2_HUMAN (O15020).

Description: Spectrin beta chain, non-erythrocytic 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 2390 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam CH 57 162
low_complexity n/a 84 95
coiled_coil n/a 116 136
Pfam CH 176 282
coiled_coil n/a 303 323
Pfam Spectrin 305 415
Pfam Spectrin 425 528
low_complexity n/a 483 494
low_complexity n/a 523 533
Pfam Spectrin 531 639
low_complexity n/a 624 643
Pfam Spectrin 641 745
disorder n/a 705 706
disorder n/a 708 722
coiled_coil n/a 715 735
low_complexity n/a 722 747
Pfam Spectrin 747 850
disorder n/a 780 784
disorder n/a 791 794
disorder n/a 796 801
disorder n/a 803 805
disorder n/a 807 832
disorder n/a 834 836
low_complexity n/a 835 854
Pfam Spectrin 852 956
disorder n/a 891 892
disorder n/a 922 933
Pfam Spectrin 958 1063
disorder n/a 978 979
coiled_coil n/a 994 1021
disorder n/a 1054 1055
Pfam Spectrin 1065 1170
disorder n/a 1088 1102
low_complexity n/a 1091 1105
low_complexity n/a 1097 1110
coiled_coil n/a 1100 1127
disorder n/a 1127 1129
Pfam Spectrin 1172 1276
disorder n/a 1190 1192
disorder n/a 1243 1244
coiled_coil n/a 1246 1266
disorder n/a 1249 1262
disorder n/a 1266 1272
Pfam Spectrin 1278 1381
Pfam Spectrin 1383 1486
coiled_coil n/a 1432 1452
disorder n/a 1445 1447
disorder n/a 1450 1462
disorder n/a 1485 1486
Pfam Spectrin 1488 1586
disorder n/a 1488 1489
disorder n/a 1513 1525
disorder n/a 1529 1532
disorder n/a 1534 1552
low_complexity n/a 1547 1568
disorder n/a 1556 1558
Pfam Spectrin 1588 1692
disorder n/a 1604 1625
disorder n/a 1648 1664
low_complexity n/a 1685 1703
Pfam Spectrin 1694 1799
low_complexity n/a 1754 1768
Pfam Spectrin 1801 1905
disorder n/a 1817 1833
disorder n/a 1856 1858
disorder n/a 1863 1868
disorder n/a 1870 1872
Pfam Spectrin 1908 2011
disorder n/a 1939 1940
coiled_coil n/a 1981 2001
Pfam Spectrin 2013 2097
coiled_coil n/a 2072 2095
low_complexity n/a 2079 2096
disorder n/a 2080 2231
low_complexity n/a 2098 2109
low_complexity n/a 2161 2172
Pfam PH_9 2220 2328
disorder n/a 2269 2273
disorder n/a 2333 2374
low_complexity n/a 2375 2388
disorder n/a 2379 2384

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O15020. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSSTLSPTDF DSLEIQGQYS DINNRWDLPD SDWDNDSSSA RLFERSRIKA
50
51
LADEREAVQK KTFTKWVNSH LARVTCRVGD LYSDLRDGRN LLRLLEVLSG
100
101
EILPKPTKGR MRIHCLENVD KALQFLKEQK VHLENMGSHD IVDGNHRLTL
150
151
GLVWTIILRF QIQDISVETE DNKEKKSAKD ALLLWCQMKT AGYPNVNVHN
200
201
FTTSWRDGLA FNAIVHKHRP DLLDFESLKK CNAHYNLQNA FNLAEKELGL
250
251
TKLLDPEDVN VDQPDEKSII TYVATYYHYF SKMKALAVEG KRIGKVLDHA
300
301
MEAERLVEKY ESLASELLQW IEQTIVTLND RQLANSLSGV QNQLQSFNSY
350
351
RTVEKPPKFT EKGNLEVLLF TIQSKLRANN QKVYTPREGR LISDINKAWE
400
401
RLEKAEHERE LALRTELIRQ EKLEQLAARF DRKAAMRETW LSENQRLVSQ
450
451
DNFGLELAAV EAAVRKHEAI ETDIVAYSGR VQAVDAVAAE LAAERYHDIK
500
501
RIAARQHNVA RLWDFLRQMV AARRERLLLN LELQKVFQDL LYLMDWMEEM
550
551
KGRLQSQDLG RHLAGVEDLL QLHELVEADI AVQAERVRAV SASALRFCNP
600
601
GKEYRPCDPQ LVSERVAKLE QSYEALCELA AARRARLEES RRLWRFLWEV
650
651
GEAEAWVREQ QHLLASADTG RDLTGALRLL NKHTALRGEM SGRLGPLKLT
700
701
LEQGQQLVAE GHPGASQASA RAAELQAQWE RLEALAEERA QRLAQAASLY
750
751
QFQADANDME AWLVDALRLV SSPELGHDEF STQALARQHR ALEEEIRSHR
800
801
PTLDALREQA AALPPTLSRT PEVQSRVPTL ERHYEELQAR AGERARALEA
850
851
ALALYTMLSE AGACGLWVEE KEQWLNGLAL PERLEDLEVV QQRFETLEPE
900
901
MNTLAAQITA VNDIAEQLLK ANPPGKDRIV NTQEQLNHRW QQFRRLADGK
950
951
KAALTSALSI QNYHLECTET QAWMREKTKV IESTQGLGND LAGVLALQRK
1000
1001
LAGTERDLEA IAARVGELTR EANALAAGHP AQAVAINARL REVQTGWEDL
1050
1051
RATMRRREES LGEARRLQDF LRSLDDFQAW LGRTQTAVAS EEGPATLPEA
1100
1101
EALLAQHAAL RGEVERAQSE YSRLRALGEE VTRDQADPQC LFLRQRLEAL
1150
1151
GTGWEELGRM WESRQGRLAQ AHGFQGFLRD ARQAEGVLSS QEYVLSHTEM
1200
1201
PGTLQAADAA IKKLEDFMST MDANGERIHG LLEAGRQLVS EGNIHADKIR
1250
1251
EKADSIERRH KKNQDAAQQF LGRLRDNREQ QHFLQDCHEL KLWIDEKMLT
1300
1301
AQDVSYDEAR NLHTKWQKHQ AFMAELAANK DWLDKVDKEG RELTLEKPEL
1350
1351
KALVSEKLRD LHRRWDELET TTQAKARSLF DANRAELFAQ SCCALESWLE
1400
1401
SLQAQLHSDD YGKDLTSVNI LLKKQQMLEW EMAVREKEVE AIQAQAKALA
1450
1451
QEDQGAGEVE RTSRAVEEKF RALCQPMRER CRRLQASREQ HQFHRDVEDE
1500
1501
ILWVTERLPM ASSMEHGKDL PSVQLLMKKN QTLQKEIQGH EPRIADLRER
1550
1551
QRALGAAAAG PELAELQEMW KRLGHELELR GKRLEDALRA QQFYRDAAEA
1600
1601
EAWMGEQELH MMGQEKAKDE LSAQAEVKKH QVLEQALADY AQTIHQLAAS
1650
1651
SQDMIDHEHP ESTRISIRQA QVDKLYAGLK ELAGERRERL QEHLRLCQLR
1700
1701
RELDDLEQWI QEREVVAASH ELGQDYEHVT MLRDKFREFS RDTSTIGQER
1750
1751
VDSANALANG LIAGGHAARA TVAEWKDSLN EAWADLLELL DTRGQVLAAA
1800
1801
YELQRFLHGA RQALARVQHK QQQLPDGTGR DLNAAEALQR RHCAYEHDIQ
1850
1851
ALSPQVQQVQ DDGHRLQKAY AGDKAEEIGR HMQAVAEAWA QLQGSSAARR
1900
1901
QLLLDTTDKF RFFKAVRELM LWMDEVNLQM DAQERPRDVS SADLVIKNQQ
1950
1951
GIKAEIEARA DRFSSCIDMG KELLARSHYA AEEISEKLSQ LQARRQETAE
2000
2001
KWQEKMDWLQ LVLEVLVFGR DAGMAEAWLC SQEPLVRSAE LGCTVDEVES
2050
2051
LIKRHEAFQK SAVAWEERFC ALEKLTALEE REKERKRKRE EEERRKQPPA
2100
2101
PEPTASVPPG DLVGGQTASD TTWDGTQPRP PPSTQAPSVN GVCTDGEPSQ
2150
2151
PLLGQQRLEH SSFPEGPGPG SGDEANGPRG ERQTRTRGPA PSAMPQSRST
2200
2201
ESAHAATLPP RGPEPSAQEQ MEGMLCRKQE MEAFGKKAAN RSWQNVYCVL
2250
2251
RRGSLGFYKD AKAASAGVPY HGEVPVSLAR AQGSVAFDYR KRKHVFKLGL
2300
2301
QDGKEYLFQA KDEAEMSSWL RVVNAAIATA SSASGEPEEP VVPSTTRGMT
2350
2351
RAMTMPPVSP VGAEGPVVLR SKDGRERERE KRFSFFKKNK           
2390
 

Show the unformatted sequence.

Checksums:
CRC64:1CC523CC6493DBFE
MD5:db71b2469dffb5d04908227063c1c28b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
CH 178 - 282 1WYQ A 8 - 112 NGL View in InterPro
57 - 162 6ANU a 1057 - 1162 NGL View in InterPro
b 1057 - 1162 NGL View in InterPro
c 1057 - 1162 NGL View in InterPro
d 1057 - 1162 NGL View in InterPro
e 1057 - 1162 NGL View in InterPro
f 1057 - 1162 NGL View in InterPro
PH_9 2220 - 2328 1WJM A 9 - 117 NGL View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;