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6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PRP4_HUMAN (O43172)

Summary

This is the summary of UniProt entry PRP4_HUMAN (O43172).

Description: U4/U6 small nuclear ribonucleoprotein Prp4
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 522 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 19
disorder n/a 37 38
disorder n/a 43 44
disorder n/a 46 47
disorder n/a 86 87
disorder n/a 98 99
Pfam PRP4 108 136
low_complexity n/a 146 161
disorder n/a 147 164
disorder n/a 195 213
Pfam WD40 215 259
Pfam WD40 263 309
Pfam WD40 313 351
Pfam WD40 397 435
Pfam WD40 439 478
Pfam WD40 482 520

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O43172. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MASSRASSTQ ATKTKAPDDL VAPVVKKPHI YYGSLEEKER ERLAKGESGI
50
51
LGKDGLKAGI EAGNINITSG EVFEIEEHIS ERQAEVLAEF ERRKRARQIN
100
101
VSTDDSEVKA CLRALGEPIT LFGEGPAERR ERLRNILSVV GTDALKKTKK
150
151
DDEKSKKSKE EYQQTWYHEG PNSLKVARLW IANYSLPRAM KRLEEARLHK
200
201
EIPETTRTSQ MQELHKSLRS LNNFCSQIGD DRPISYCHFS PNSKMLATAC
250
251
WSGLCKLWSV PDCNLLHTLR GHNTNVGAIV FHPKSTVSLD PKDVNLASCA
300
301
ADGSVKLWSL DSDEPVADIE GHTVRVARVM WHPSGRFLGT TCYDRSWRLW
350
351
DLEAQEEILH QEGHSMGVYD IAFHQDGSLA GTGGLDAFGR VWDLRTGRCI
400
401
MFLEGHLKEI YGINFSPNGY HIATGSGDNT CKVWDLRQRR CVYTIPAHQN
450
451
LVTGVKFEPI HGNFLLTGAY DNTAKIWTHP GWSPLKTLAG HEGKVMGLDI
500
501
SSDGQLIATC SYDRTFKLWM AE                              
522
 

Show the unformatted sequence.

Checksums:
CRC64:08975A26D0B21857
MD5:ac533f2d5cf7a9b7e94d376cb562bd78

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PRP4 108 - 136 1MZW B 107 - 135 Show 3D Structure View in InterPro
5O9Z F 107 - 135 Show 3D Structure View in InterPro
WD40 215 - 259 5O9Z F 214 - 258 Show 3D Structure View in InterPro
6AH0 K 215 - 259 Show 3D Structure View in InterPro
6QW6 4B 215 - 259 Show 3D Structure View in InterPro
6QX9 4B 215 - 259 Show 3D Structure View in InterPro
216 - 259 3JCR L 216 - 259 Show 3D Structure View in InterPro
263 - 309 3JCR L 263 - 309 Show 3D Structure View in InterPro
5O9Z F 262 - 308 Show 3D Structure View in InterPro
6AH0 K 263 - 309 Show 3D Structure View in InterPro
6QW6 4B 263 - 309 Show 3D Structure View in InterPro
6QX9 4B 263 - 309 Show 3D Structure View in InterPro
313 - 351 3JCR L 313 - 351 Show 3D Structure View in InterPro
5O9Z F 312 - 350 Show 3D Structure View in InterPro
6QW6 4B 313 - 351 Show 3D Structure View in InterPro
6QX9 4B 313 - 351 Show 3D Structure View in InterPro
316 - 351 6AH0 K 316 - 351 Show 3D Structure View in InterPro
397 - 435 3JCR L 397 - 435 Show 3D Structure View in InterPro
5O9Z F 396 - 434 Show 3D Structure View in InterPro
6AH0 K 397 - 435 Show 3D Structure View in InterPro
6QW6 4B 397 - 435 Show 3D Structure View in InterPro
6QX9 4B 397 - 435 Show 3D Structure View in InterPro
439 - 478 3JCR L 439 - 478 Show 3D Structure View in InterPro
5O9Z F 438 - 477 Show 3D Structure View in InterPro
6AH0 K 439 - 478 Show 3D Structure View in InterPro
6QW6 4B 439 - 478 Show 3D Structure View in InterPro
6QX9 4B 439 - 478 Show 3D Structure View in InterPro
482 - 520 3JCR L 482 - 520 Show 3D Structure View in InterPro
5O9Z F 481 - 519 Show 3D Structure View in InterPro
6AH0 K 482 - 520 Show 3D Structure View in InterPro
6QW6 4B 482 - 520 Show 3D Structure View in InterPro
6QX9 4B 482 - 520 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;