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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: M3K13_HUMAN (O43283)

Summary

This is the summary of UniProt entry M3K13_HUMAN (O43283).

Description: Mitogen-activated protein kinase kinase kinase 13 EC=2.7.11.25
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 966 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 3 57
low_complexity n/a 59 73
disorder n/a 64 65
disorder n/a 67 73
disorder n/a 80 118
low_complexity n/a 120 138
Pfam PK_Tyr_Ser-Thr 168 407
low_complexity n/a 447 467
coiled_coil n/a 462 496
disorder n/a 502 661
low_complexity n/a 567 592
low_complexity n/a 589 600
disorder n/a 677 696
disorder n/a 702 711
disorder n/a 719 720
disorder n/a 740 741
disorder n/a 743 834
low_complexity n/a 811 828
disorder n/a 849 904
disorder n/a 908 910
disorder n/a 936 952
low_complexity n/a 939 952

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O43283. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MANFQEHLSC SSSPHLPFSE SKTFNGLQDE LTAMGNHPSP KLLEDQQEKG
50
51
MVRTELIESV HSPVTTTVLT SVSEDSRDQF ENSVLQLREH DESETAVSQG
100
101
NSNTVDGEST SGTEDIKIQF SRSGSGSGGF LEGLFGCLRP VWNIIGKAYS
150
151
TDYKLQQQDT WEVPFEEISE LQWLGSGAQG AVFLGKFRAE EVAIKKVREQ
200
201
NETDIKHLRK LKHPNIIAFK GVCTQAPCYC IIMEYCAHGQ LYEVLRAGRK
250
251
ITPRLLVDWS TGIASGMNYL HLHKIIHRDL KSPNVLVTHT DAVKISDFGT
300
301
SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE
350
351
IPYKDVDSSA IIWGVGSNSL HLPVPSTCPD GFKILMKQTW QSKPRNRPSF
400
401
RQTLMHLDIA SADVLATPQE TYFKSQAEWR EEVKKHFEKI KSEGTCIHRL
450
451
DEELIRRRRE ELRHALDIRE HYERKLERAN NLYMELSAIM LQLEMREKEL
500
501
IKREQAVEKK YPGTYKRHPV RPIIHPNAME KLMKRKGVPH KSGMQTKRPD
550
551
LLRSEGIPTT EVAPTASPLS GSPKMSTSSS KSRYRSKPRH RRGNSRGSHS
600
601
DFAAILKNQP AQENSPHPTY LHQAQSQYPS LHHHNSLQQQ YQQPPPAMSQ
650
651
SHHPRLNMHG QDIATCANNL RYFGPAAALR SPLSNHAQRQ LPGSSPDLIS
700
701
TAMAADCWRS SEPDKGQAGP WGCCQADAYD PCLQCRPEQY GSLDIPSAEP
750
751
VGRSPDLSKS PAHNPLLENA QSSEKTEENE FSGCRSESSL GTSHLGTPPA
800
801
LPRKTRPLQK SGDDSSEEEE GEVDSEVEFP RRQRPHRCIS SCQSYSTFSS
850
851
ENFSVSDGEE GNTSDHSNSP DELADKLEDR LAEKLDDLLS QTPEIPIDIS
900
901
SHSDGLSDKE CAVRRVKTQM SLGKLCVEER GYENPMQFEE SDCDSSDGEC
950
951
SDATVRTNKH YSSATW                                     
966
 

Show the unformatted sequence.

Checksums:
CRC64:9687F38C8AB20AB1
MD5:6067ec91d17b40c80ee27fab40d80eb0

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.