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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DHH_HUMAN (O43323)

Summary

This is the summary of UniProt entry DHH_HUMAN (O43323).

Description: Desert hedgehog protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 396 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 22
low_complexity n/a 2 20
Pfam HH_signal 23 185
low_complexity n/a 24 34
disorder n/a 59 65
Pfam Hint 187 396
low_complexity n/a 309 324
low_complexity n/a 358 374

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O43323. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MALLTNLLPL CCLALLALPA QSCGPGRGPV GRRRYARKQL VPLLYKQFVP
50
51
GVPERTLGAS GPAEGRVARG SERFRDLVPN YNPDIIFKDE ENSGADRLMT
100
101
ERCKERVNAL AIAVMNMWPG VRLRVTEGWD EDGHHAQDSL HYEGRALDIT
150
151
TSDRDRNKYG LLARLAVEAG FDWVYYESRN HVHVSVKADN SLAVRAGGCF
200
201
PGNATVRLWS GERKGLRELH RGDWVLAADA SGRVVPTPVL LFLDRDLQRR
250
251
ASFVAVETEW PPRKLLLTPW HLVFAARGPA PAPGDFAPVF ARRLRAGDSV
300
301
LAPGGDALRP ARVARVAREE AVGVFAPLTA HGTLLVNDVL ASCYAVLESH
350
351
QWAHRAFAPL RLLHALGALL PGGAVQPTGM HWYSRLLYRL AEELLG    
396
 

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Checksums:
CRC64:FCE4FB21972C3AD5
MD5:963afe9adcab0f07b440bd04f537f395

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
HH_signal 39 - 185 2WFR A 39 - 185 NGL View in InterPro
3N1G A 39 - 185 NGL View in InterPro
B 39 - 185 NGL View in InterPro
3N1Q A 39 - 185 NGL View in InterPro
B 39 - 185 NGL View in InterPro
40 - 185 2WFQ A 40 - 185 NGL View in InterPro
2WG3 A 40 - 185 NGL View in InterPro
B 40 - 185 NGL View in InterPro
3N1Q E 40 - 185 NGL View in InterPro
Hint 187 - 189 3N1G A 187 - 189 NGL View in InterPro
B 187 - 189 NGL View in InterPro
3N1Q A 187 - 189 NGL View in InterPro
B 187 - 189 NGL View in InterPro
E 187 - 189 NGL View in InterPro
187 - 192 2WG3 B 187 - 192 NGL View in InterPro
187 - 194 2WG3 A 187 - 194 NGL View in InterPro
187 - 195 2WFQ A 187 - 195 NGL View in InterPro
2WFR A 187 - 195 NGL View in InterPro
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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.