Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: IF4G3_HUMAN (O43432)

Summary

This is the summary of UniProt entry IF4G3_HUMAN (O43432).

Description: Eukaryotic translation initiation factor 4 gamma 3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1585 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 46
low_complexity n/a 10 21
disorder n/a 52 55
disorder n/a 62 67
disorder n/a 69 113
low_complexity n/a 75 105
disorder n/a 119 281
low_complexity n/a 129 134
low_complexity n/a 174 189
low_complexity n/a 262 274
disorder n/a 297 301
disorder n/a 303 339
disorder n/a 353 354
disorder n/a 360 361
low_complexity n/a 379 396
disorder n/a 384 389
disorder n/a 396 436
low_complexity n/a 405 433
low_complexity n/a 432 448
disorder n/a 443 450
disorder n/a 457 531
coiled_coil n/a 515 535
low_complexity n/a 520 535
disorder n/a 533 622
low_complexity n/a 594 603
disorder n/a 645 659
disorder n/a 661 672
disorder n/a 674 716
disorder n/a 729 750
Pfam MIF4G 755 983
disorder n/a 860 862
disorder n/a 865 879
disorder n/a 955 957
disorder n/a 995 1043
coiled_coil n/a 1000 1020
disorder n/a 1046 1052
disorder n/a 1066 1218
low_complexity n/a 1073 1086
low_complexity n/a 1106 1117
low_complexity n/a 1214 1228
disorder n/a 1220 1221
Pfam MA3 1222 1334
coiled_coil n/a 1416 1436
Pfam W2 1506 1585
disorder n/a 1583 1585

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O43432. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNSQPQTRSP FFQRPQIQPP RATIPNSSPS IRPGAQTPTA VYQANQHIMM
50
51
VNHLPMPYPV PQGPQYCIPQ YRHSGPPYVG PPQQYPVQPP GPGPFYPGPG
100
101
PGDFPNAYGT PFYPSQPVYQ SAPIIVPTQQ QPPPAKREKK TIRIRDPNQG
150
151
GKDITEEIMS GGGSRNPTPP IGRPTSTPTP PQQLPSQVPE HSPVVYGTVE
200
201
SAHLAASTPV TAASDQKQEE KPKPDPVLKS PSPVLRLVLS GEKKEQEGQT
250
251
SETTAIVSIA ELPLPPSPTT VSSVARSTIA APTSSALSSQ PIFTTAIDDR
300
301
CELSSPREDT IPIPSLTSCT ETSDPLPTNE NDDDICKKPC SVAPNDIPLV
350
351
SSTNLINEIN GVSEKLSATE SIVEIVKQEV LPLTLELEIL ENPPEEMKLE
400
401
CIPAPITPST VPSFPPTPPT PPASPPHTPV IVPAAATTVS SPSAAITVQR
450
451
VLEEDESIRT CLSEDAKEIQ NKIEVEADGQ TEEILDSQNL NSRRSPVPAQ
500
501
IAITVPKTWK KPKDRTRTTE EMLEAELELK AEEELSIDKV LESEQDKMSQ
550
551
GFHPERDPSD LKKVKAVEEN GEEAEPVRNG AESVSEGEGI DANSGSTDSS
600
601
GDGVTFPFKP ESWKPTDTEG KKQYDREFLL DFQFMPACIQ KPEGLPPISD
650
651
VVLDKINQPK LPMRTLDPRI LPRGPDFTPA FADFGRQTPG GRGVPLLNVG
700
701
SRRSQPGQRR EPRKIITVSV KEDVHLKKAE NAWKPSQKRD SQADDPENIK
750
751
TQELFRKVRS ILNKLTPQMF NQLMKQVSGL TVDTEERLKG VIDLVFEKAI
800
801
DEPSFSVAYA NMCRCLVTLK VPMADKPGNT VNFRKLLLNR CQKEFEKDKA
850
851
DDDVFEKKQK ELEAASAPEE RTRLHDELEE AKDKARRRSI GNIKFIGELF
900
901
KLKMLTEAIM HDCVVKLLKN HDEESLECLC RLLTTIGKDL DFEKAKPRMD
950
951
QYFNQMEKIV KERKTSSRIR FMLQDVIDLR LCNWVSRRAD QGPKTIEQIH
1000
1001
KEAKIEEQEE QRKVQQLMTK EKRRPGVQRV DEGGWNTVQG AKNSRVLDPS
1050
1051
KFLKITKPTI DEKIQLVPKA QLGSWGKGSS GGAKASETDA LRSSASSLNR
1100
1101
FSALQPPAPS GSTPSTPVEF DSRRTLTSRG SMGREKNDKP LPSATARPNT
1150
1151
FMRGGSSKDL LDNQSQEEQR REMLETVKQL TGGVDVERNS TEAERNKTRE
1200
1201
SAKPEISAMS AHDKAALSEE ELERKSKSII DEFLHINDFK EAMQCVEELN
1250
1251
AQGLLHVFVR VGVESTLERS QITRDHMGQL LYQLVQSEKL SKQDFFKGFS
1300
1301
ETLELADDMA IDIPHIWLYL AELVTPMLKE GGISMRELTI EFSKPLLPVG
1350
1351
RAGVLLSEIL HLLCKQMSHK KVGALWREAD LSWKDFLPEG EDVHNFLLEQ
1400
1401
KLDFIESDSP CSSEALSKKE LSAEELYKRL EKLIIEDKAN DEQIFDWVEA
1450
1451
NLDEIQMSSP TFLRALMTAV CKAAIIADSS TFRVDTAVIK QRVPILLKYL
1500
1501
DSDTEKELQA LYALQASIVK LDQPANLLRM FFDCLYDEEV ISEDAFYKWE
1550
1551
SSKDPAEQNG KGVALKSVTA FFTWLREAEE ESEDN                
1585
 

Show the unformatted sequence.

Checksums:
CRC64:EA483139373DCA5C
MD5:0a0f0a858fa414fd36521d904cb9343d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
MIF4G 755 - 983 1HU3 A 755 - 983 NGL View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.