Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PKS5_MYCTU (O53901)

Summary

This is the summary of UniProt entry PKS5_MYCTU (O53901).

Description: Mycocerosic acid synthase-like polyketide synthase {ECO:0000303|PubMed:12855735}
Source organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (NCBI taxonomy ID 83332)
Length: 2108 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 7
Pfam ketoacyl-synt 14 263
disorder n/a 58 59
disorder n/a 118 120
Pfam Ketoacyl-synt_C 271 385
disorder n/a 285 287
disorder n/a 317 321
Pfam KAsynt_C_assoc 389 513
disorder n/a 403 422
disorder n/a 431 453
disorder n/a 477 478
disorder n/a 494 496
low_complexity n/a 508 529
disorder n/a 511 512
disorder n/a 524 542
Pfam Acyl_transf_1 546 863
low_complexity n/a 848 862
low_complexity n/a 885 895
Pfam PS-DH 905 1192
disorder n/a 908 910
disorder n/a 918 923
disorder n/a 925 927
low_complexity n/a 955 966
disorder n/a 997 1003
disorder n/a 1021 1041
low_complexity n/a 1126 1138
disorder n/a 1207 1209
disorder n/a 1252 1254
disorder n/a 1259 1265
low_complexity n/a 1270 1282
disorder n/a 1281 1284
disorder n/a 1286 1297
disorder n/a 1333 1338
disorder n/a 1343 1347
disorder n/a 1361 1366
disorder n/a 1373 1378
disorder n/a 1381 1382
disorder n/a 1400 1401
disorder n/a 1405 1419
disorder n/a 1436 1437
Pfam ADH_N 1446 1526
low_complexity n/a 1485 1496
low_complexity n/a 1532 1546
low_complexity n/a 1567 1591
Pfam ADH_zinc_N 1570 1700
low_complexity n/a 1637 1651
Pfam KR 1765 1943
low_complexity n/a 1771 1778
Pfam PP-binding 2029 2094
disorder n/a 2104 2108

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O53901. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGKERTKTVD RTRVTPVAVI GMGCRLPGGI DSPDRLWEAL LRGDDLVTEI
50
51
PADRWDIDEY YDPEPGVPGR TDCKWGAYLD NVGDFDPEFF GIGEKEAIAI
100
101
DPQHRLLLET SWEAMEHGGL TPNQMASRTG VFVGLVHTDY ILVHADNQTF
150
151
EGPYGNTGTN ACFASGRVAY AMGLQGPAIT VDTACSSGLT AIHLACRSLH
200
201
DGESDIALAG GVYVMLEPRR FASGSALGML SATGRCHAFD VSADGFVSGE
250
251
GCVMLALKRL PDALADGDRI LAVIRGTAAN QDGHTVNIAT PSRSAQVAAY
300
301
REALDVAGVD PATVGMVEAH GPGTPVGDPI EYASLAEVYG NDGPCALASV
350
351
KTNFGHTQSA AGALGLMKAV LALQHGVVPQ NLHFTALPDK LAAIETNLFV
400
401
PQEITPWPGA DQETPRRAAV SSYGMTGTNV HAIVEQAPVP APESGAPGDT
450
451
PATPGIDGAL LFALSASSQD ALRQTAARLA DWVDAQGPEL APADLAYTLA
500
501
RRRGHRPVRT AVLAATTAEL TEALREVATG EPPYPPAVGQ DDRGPVWVFS
550
551
GQGSQWAGMG ADLLATEPVF AATIAAIEPL IAAESGFSVT EAMTAPEVVT
600
601
GIDRVQPTLF AMQVALAATM KSYGVAPGAV IGHSLGESAA AVVAGALCLE
650
651
DGVRVICRRS ALMTRIAGAG AMASVELPAQ QVLSELMARG VNDAVVAVVA
700
701
SPQSTVIGGA TQTVRDLVAA WEQRDVLARE VAVDVASHSP QVDPILDELA
750
751
EALAEISPLQ PEIPYYSATS FDPREEPYCD AYYWVDNLRH TVRFAAAVQA
800
801
ALEDGYRVFT ELTPHPLLTH AVDQTARSLD MSAAALAGMR REQPLPHGLR
850
851
ALAGDLYAAG AAVDFAVLYP TGRLINAPLP TWNHRRLLLD DTTRRIAHAN
900
901
TVAVHPLLGS HVRLPEEPER HVWQGEVGTV TQPWLADHQI HGAAALPGAA
950
951
YCEMALAAAR AVLGEASEVR DIRFEQMLLL DDETPIGVTA TVEAPGVVPL
1000
1001
TVETSHDGRY TRQLAAVLHV VREADDAPDQ PPQKNIAELL ASHPHKVDGA
1050
1051
EVRQWLDKRG HRLGPAFAGL VDAYIAEGAG DTVLAEVNLP GPLRSQVKAY
1100
1101
GVHPVLLDAC FQSVAAHPAV QGMADGGLLL PLGVRRLRSY GSARHARYCC
1150
1151
TTVTACGVGV EADLDVLDEH GAVVLAVRGL QLGTGASQAS ERARVLGERL
1200
1201
LSIEWHEREL PENSHAEPGA WLLISTCDAT DLVAAQLTDA LKVHDAQCTT
1250
1251
MSWPQRADHA AQAARLRDQL GTGGFTGVFV LTAPQTGDPD AESPVRGGEL
1300
1301
VKHVVRIARE IPEITAQEPR LYVLTHNAQA VLSGDRPNLE QGGMRGLLRV
1350
1351
IGAEHPHLKA SYVDVDEQTG AESVARQLLA ASGEDETAWR NDQWYTARLC
1400
1401
PAPLRPEERQ TTVVDHAEAG MRLQIRTPGD LQTLEFAAFD RVPPGPGEIE
1450
1451
VAVTASSINF ADVLVTFGRY QTLDGRQPQL GTDFAGVVSA VGPGVSELKV
1500
1501
GDRVGGMSPN GCWATFVTCD ARLATRLPEG LTDAQAAAVT TASATAWYGL
1550
1551
QDLARIKAGD KVLIHSATGG VGQAAIAIAR AAGAQIYATA GNEKRRDLLR
1600
1601
DMGIEHVYDS RSVEFAEQIR RDTAGYGVDI VLNSVTGAAQ LAGLKLLALG
1650
1651
GRFIEIGKRD IYSNTRLELL PFRRNLAFYG LDLGLMSVSH PAAVRELLST
1700
1701
VYRLTVEGVL PMPQSTHYPL AEAATAIRVM GAAEHTGKLI LDVPHAGRSS
1750
1751
VVLPPEQARV FRSDGSYIIT GGLGGLGLFL AEKMANAGAG RIVLSSRSQP
1800
1801
SQKALETIEL VRAIGSDVVV ECGDIAQPDT ADRLVTAATA TGLPLRGVLH
1850
1851
AAAVVEDATL ANITDELIER DWAPKAYGAW QLHRATADQP LDWFCSFSSA
1900
1901
AALVGSPGQG AYAAANSWLD TFTHWRRAQD LPATSIAWGA WGQIGRAIAF
1950
1951
AEQTGDAIAP EEGAYAFETL LRHNRAYSGY APVIGSPWLT AFAQHSPFAE
2000
2001
KFQSLGQNRS GTSKFLAELV DLPREEWPDR LRRLLSKQVG LILRRTIDTD
2050
2051
RLLSEYGLDS LSSQELRARV EAETGIRISA TEINTTVRGL ADLMCDKLAA
2100
2101
DRDAPAPA                                              
2108
 

Show the unformatted sequence.

Checksums:
CRC64:1E3223687968A103
MD5:a73b0285e9708dced41aaa602872c7a0

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;