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12  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: AQR_HUMAN (O60306)

Summary

This is the summary of UniProt entry AQR_HUMAN (O60306).

Description: RNA helicase aquarius {ECO:0000303|PubMed:25599396}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1485 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam Aquarius_N 18 802
low_complexity n/a 112 125
disorder n/a 605 616
disorder n/a 619 622
disorder n/a 639 641
disorder n/a 705 706
disorder n/a 758 780
low_complexity n/a 762 776
disorder n/a 786 798
Pfam AAA_11 801 1107
disorder n/a 803 806
disorder n/a 818 825
low_complexity n/a 873 887
Pfam AAA_12 1115 1308
disorder n/a 1334 1354
disorder n/a 1383 1485
coiled_coil n/a 1390 1410
low_complexity n/a 1391 1414

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O60306. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAPAQPKKI VAPTVSQINA EFVTQLACKY WAPHIKKKSP FDIKVIEDIY
50
51
EKEIVKSRFA IRKIMLLEFS QYLENYLWMN YSPEVSSKAY LMSICCMVNE
100
101
KFRENVPAWE IFKKKPDHFP FFFKHILKAA LAETDGEFSL HEQTVLLLFL
150
151
DHCFNSLEVD LIRSQVQQLI SLPMWMGLQL ARLELELKKT PKLRKFWNLI
200
201
KKNDEKMDPE AREQAYQERR FLSQLIQKFI SVLKSVPLSE PVTMDKVHYC
250
251
ERFIELMIDL EALLPTRRWF NTILDDSHLL VHCYLSNLVR REEDGHLFSQ
300
301
LLDMLKFYTG FEINDQTGNA LTENEMTTIH YDRITSLQRA AFAHFPELYD
350
351
FALSNVAEVD TRESLVKFFG PLSSNTLHQV ASYLCLLPTL PKNEDTTFDK
400
401
EFLLELLVSR HERRISQIQQ LNQMPLYPTE KIIWDENIVP TEYYSGEGCL
450
451
ALPKLNLQFL TLHDYLLRNF NLFRLESTYE IRQDIEDSVS RMKPWQSEYG
500
501
GVVFGGWARM AQPIVAFTVV EVAKPNIGEN WPTRVRADVT INLNVRDHIK
550
551
DEWEGLRKHD VCFLITVRPT KPYGTKFDRR RPFIEQVGLV YVRGCEIQGM
600
601
LDDKGRVIED GPEPRPNLRG ESRTFRVFLD PNQYQQDMTN TIQNGAEDVY
650
651
ETFNIIMRRK PKENNFKAVL ETIRNLMNTD CVVPDWLHDI ILGYGDPSSA
700
701
HYSKMPNQIA TLDFNDTFLS IEHLKASFPG HNVKVTVEDP ALQIPPFRIT
750
751
FPVRSGKGKK RKDADVEDED TEEAKTLIVE PHVIPNRGPY PYNQPKRNTI
800
801
QFTHTQIEAI RAGMQPGLTM VVGPPGTGKT DVAVQIISNI YHNFPEQRTL
850
851
IVTHSNQALN QLFEKIMALD IDERHLLRLG HGEEELETEK DFSRYGRVNY
900
901
VLARRIELLE EVKRLQKSLG VPGDASYTCE TAGYFFLYQV MSRWEEYISK
950
951
VKNKGSTLPD VTEVSTFFPF HEYFANAPQP IFKGRSYEED MEIAEGCFRH
1000
1001
IKKIFTQLEE FRASELLRSG LDRSKYLLVK EAKIIAMTCT HAALKRHDLV
1050
1051
KLGFKYDNIL MEEAAQILEI ETFIPLLLQN PQDGFSRLKR WIMIGDHHQL
1100
1101
PPVIKNMAFQ KYSNMEQSLF TRFVRVGVPT VDLDAQGRAR ASLCNLYNWR
1150
1151
YKNLGNLPHV QLLPEFSTAN AGLLYDFQLI NVEDFQGVGE SEPNPYFYQN
1200
1201
LGEAEYVVAL FMYMCLLGYP ADKISILTTY NGQKHLIRDI INRRCGNNPL
1250
1251
IGRPNKVTTV DRFQGQQNDY ILLSLVRTRA VGHLRDVRRL VVAMSRARLG
1300
1301
LYIFARVSLF QNCFELTPAF SQLTARPLHL HIIPTEPFPT TRKNGERPSH
1350
1351
EVQIIKNMPQ MANFVYNMYM HLIQTTHHYH QTLLQLPPAM VEEGEEVQNQ
1400
1401
ETELETEEEA MTVQADIIPS PTDTSCRQET PAFQTDTTPS ETGATSTPEA
1450
1451
IPALSETTPT VVGAVSAPAE ANTPQDATSA PEETK                
1485
 

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Checksums:
CRC64:D0ADDA621A9418FD
MD5:9b4ed38d36ec4a568649facaee0f48a9

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
AAA_11 801 - 1107 4PJ3 A 801 - 1107 Show 3D Structure View in InterPro
5MQF U 801 - 1107 Show 3D Structure View in InterPro
5XJC Q 801 - 1107 Show 3D Structure View in InterPro
5YZG Q 801 - 1107 Show 3D Structure View in InterPro
5Z56 Q 801 - 1107 Show 3D Structure View in InterPro
5Z57 Q 801 - 1107 Show 3D Structure View in InterPro
6FF7 U 801 - 1107 Show 3D Structure View in InterPro
6ICZ Q 801 - 1107 Show 3D Structure View in InterPro
6ID0 Q 801 - 1107 Show 3D Structure View in InterPro
6ID1 Q 801 - 1107 Show 3D Structure View in InterPro
6QDV U 801 - 1107 Show 3D Structure View in InterPro
7A5P U 801 - 1107 Show 3D Structure View in InterPro
AAA_12 1115 - 1308 4PJ3 A 1115 - 1308 Show 3D Structure View in InterPro
5MQF U 1115 - 1308 Show 3D Structure View in InterPro
5XJC Q 1115 - 1308 Show 3D Structure View in InterPro
5YZG Q 1115 - 1308 Show 3D Structure View in InterPro
5Z56 Q 1115 - 1308 Show 3D Structure View in InterPro
5Z57 Q 1115 - 1308 Show 3D Structure View in InterPro
6FF7 U 1115 - 1308 Show 3D Structure View in InterPro
6ICZ Q 1115 - 1308 Show 3D Structure View in InterPro
6ID0 Q 1115 - 1308 Show 3D Structure View in InterPro
6ID1 Q 1115 - 1308 Show 3D Structure View in InterPro
6QDV U 1115 - 1308 Show 3D Structure View in InterPro
7A5P U 1115 - 1308 Show 3D Structure View in InterPro
Aquarius_N 19 - 802 4PJ3 A 19 - 802 Show 3D Structure View in InterPro
5MQF U 19 - 802 Show 3D Structure View in InterPro
5XJC Q 19 - 802 Show 3D Structure View in InterPro
5YZG Q 19 - 802 Show 3D Structure View in InterPro
6FF7 U 19 - 802 Show 3D Structure View in InterPro
6ICZ Q 19 - 802 Show 3D Structure View in InterPro
6ID0 Q 19 - 802 Show 3D Structure View in InterPro
6ID1 Q 19 - 802 Show 3D Structure View in InterPro
6QDV U 19 - 802 Show 3D Structure View in InterPro
7A5P U 19 - 802 Show 3D Structure View in InterPro
21 - 802 5Z56 Q 21 - 802 Show 3D Structure View in InterPro
5Z57 Q 21 - 802 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;