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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ZIC3_HUMAN (O60481)

Summary

This is the summary of UniProt entry ZIC3_HUMAN (O60481).

Description: Zinc finger protein ZIC 3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 467 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 13 42
low_complexity n/a 46 63
disorder n/a 66 107
low_complexity n/a 87 97
disorder n/a 123 135
low_complexity n/a 124 135
disorder n/a 137 147
disorder n/a 158 187
disorder n/a 197 201
disorder n/a 203 207
disorder n/a 210 216
Pfam zf_ZIC 244 290
disorder n/a 279 285
Pfam zf-C2H2 295 322
Pfam zf-C2H2 328 352
Pfam zf-C2H2 358 382
disorder n/a 373 378
Pfam zf-C2H2 388 410
disorder n/a 403 462
low_complexity n/a 411 428

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O60481. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTMLLDGGPQ FPGLGVGSFG APRHHEMPNR EPAGMGLNPF GDSTHAAAAA
50
51
AAAAAFKLSP AAAHDLSSGQ SSAFTPQGSG YANALGHHHH HHHHHHHTSQ
100
101
VPSYGGAASA AFNSTREFLF RQRSSGLSEA ASGGGQHGLF AGSASSLHAP
150
151
AGIPEPPSYL LFPGLHEQGA GHPSPTGHVD NNQVHLGLRG ELFGRADPYR
200
201
PVASPRTDPY AAGAQFPNYS PMNMNMGVNV AAHHGPGAFF RYMRQPIKQE
250
251
LSCKWIDEAQ LSRPKKSCDR TFSTMHELVT HVTMEHVGGP EQNNHVCYWE
300
301
ECPREGKSFK AKYKLVNHIR VHTGEKPFPC PFPGCGKIFA RSENLKIHKR
350
351
THTGEKPFKC EFEGCDRRFA NSSDRKKHMH VHTSDKPYIC KVCDKSYTHP
400
401
SSLRKHMKVH ESQGSDSSPA ASSGYESSTP PAIASANSKD TTKTPSAVQT
450
451
STSHNPGLPP NFNEWYV                                    
467
 

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Checksums:
CRC64:3150CF13C0679568
MD5:b2daa0c0f3120f23c7fe601510d1082e

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
zf-C2H2 295 - 322 2EJ4 A 58 - 85 Show 3D Structure View in InterPro
2RPC A 58 - 85 Show 3D Structure View in InterPro
328 - 352 2RPC A 91 - 115 Show 3D Structure View in InterPro
358 - 382 2RPC A 121 - 145 Show 3D Structure View in InterPro
zf_ZIC 245 - 290 2EJ4 A 8 - 53 Show 3D Structure View in InterPro
2RPC A 8 - 53 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;