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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SDC3_HUMAN (O75056)

Summary

This is the summary of UniProt entry SDC3_HUMAN (O75056).

Description: Syndecan-3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 442 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 20
low_complexity n/a 3 47
disorder n/a 22 24
disorder n/a 49 87
low_complexity n/a 62 78
disorder n/a 90 93
disorder n/a 98 101
disorder n/a 110 368
low_complexity n/a 156 171
low_complexity n/a 174 202
low_complexity n/a 204 238
low_complexity n/a 275 286
low_complexity n/a 333 348
disorder n/a 371 374
Pfam Syndecan 378 440
transmembrane n/a 385 409
low_complexity n/a 385 408
disorder n/a 419 430
disorder n/a 432 433

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O75056. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKPGPPHRAG AAHGAGAGAG AAAGPGARGL LLPPLLLLLL AGRAAGAQRW
50
51
RSENFERPVD LEGSGDDDSF PDDELDDLYS GSGSGYFEQE SGIETAMRFS
100
101
PDVALAVSTT PAVLPTTNIQ PVGTPFEELP SERPTLEPAT SPLVVTEVPE
150
151
EPSQRATTVS TTMATTAATS TGDPTVATVP ATVATATPST PAAPPFTATT
200
201
AVIRTTGVRR LLPLPLTTVA TARATTPEAP SPPTTAAVLD TEAPTPRLVS
250
251
TATSRPRALP RPATTQEPDI PERSTLPLGT TAPGPTEVAQ TPTPETFLTT
300
301
IRDEPEVPVS GGPSGDFELP EEETTQPDTA NEVVAVGGAA AKASSPPGTL
350
351
PKGARPGPGL LDNAIDSGSS AAQLPQKSIL ERKEVLVAVI VGGVVGALFA
400
401
AFLVTLLIYR MKKKDEGSYT LEEPKQASVT YQKPDKQEEF YA        
442
 

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Checksums:
CRC64:D4C284CBC36A92E2
MD5:13e811916b24550f9a273a27e6adbd69

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;