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46  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: EED_HUMAN (O75530)

Summary

This is the summary of UniProt entry EED_HUMAN (O75530).

Description: Polycomb protein EED {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 441 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 68
low_complexity n/a 66 84
disorder n/a 99 100
Pfam WD40 180 219
Pfam WD40 225 264

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O75530. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSEREVSTAP AGTDMPAAKK QKLSSDENSN PDLSGDENDD AVSIESGTNT
50
51
ERPDTPTNTP NAPGRKSWGK GKWKSKKCKY SFKCVNSLKE DHNQPLFGVQ
100
101
FNWHSKEGDP LVFATVGSNR VTLYECHSQG EIRLLQSYVD ADADENFYTC
150
151
AWTYDSNTSH PLLAVAGSRG IIRIINPITM QCIKHYVGHG NAINELKFHP
200
201
RDPNLLLSVS KDHALRLWNI QTDTLVAIFG GVEGHRDEVL SADYDLLGEK
250
251
IMSCGMDHSL KLWRINSKRM MNAIKESYDY NPNKTNRPFI SQKIHFPDFS
300
301
TRDIHRNYVD CVRWLGDLIL SKSCENAIVC WKPGKMEDDI DKIKPSESNV
350
351
TILGRFDYSQ CDIWYMRFSM DFWQKMLALG NQVGKLYVWD LEVEDPHKAK
400
401
CTTLTHHKCG AAIRQTSFSR DSSILIAVCD DASIWRWDRL R         
441
 

Show the unformatted sequence.

Checksums:
CRC64:D2E0A5BA27C0499A
MD5:bb85b0269cb8331d34f41fba1755fea0

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
WD40 180 - 219 3IIW A 180 - 219 NGL View in InterPro
3IIY A 180 - 219 NGL View in InterPro
3IJ0 A 180 - 219 NGL View in InterPro
3IJ1 A 180 - 219 NGL View in InterPro
3IJC A 180 - 219 NGL View in InterPro
3JPX A 180 - 219 NGL View in InterPro
3JZG A 180 - 219 NGL View in InterPro
3JZH A 180 - 219 NGL View in InterPro
3JZN A 180 - 219 NGL View in InterPro
3K26 A 180 - 219 NGL View in InterPro
3K27 A 180 - 219 NGL View in InterPro
4W2R E 166 - 205 NGL View in InterPro
F 166 - 205 NGL View in InterPro
4X3E A 180 - 219 NGL View in InterPro
5GSA A 180 - 219 NGL View in InterPro
B 180 - 219 NGL View in InterPro
5H13 A 180 - 219 NGL View in InterPro
5H14 A 180 - 219 NGL View in InterPro
B 180 - 219 NGL View in InterPro
5H15 A 180 - 219 NGL View in InterPro
B 180 - 219 NGL View in InterPro
5H17 A 180 - 219 NGL View in InterPro
5H19 A 180 - 219 NGL View in InterPro
5H24 A 180 - 219 NGL View in InterPro
B 180 - 219 NGL View in InterPro
5H25 A 180 - 219 NGL View in InterPro
B 180 - 219 NGL View in InterPro
5HYN B 180 - 219 NGL View in InterPro
G 180 - 219 NGL View in InterPro
L 180 - 219 NGL View in InterPro
R 180 - 219 NGL View in InterPro
5IJ7 E 166 - 205 NGL View in InterPro
F 166 - 205 NGL View in InterPro
5IJ8 E 166 - 205 NGL View in InterPro
F 166 - 205 NGL View in InterPro
5K0M A 180 - 219 NGL View in InterPro
5LS6 B 180 - 219 NGL View in InterPro
E 180 - 219 NGL View in InterPro
H 180 - 219 NGL View in InterPro
K 180 - 219 NGL View in InterPro
5TTW A 180 - 219 NGL View in InterPro
C 180 - 219 NGL View in InterPro
5U5H A 180 - 219 NGL View in InterPro
5U5K A 180 - 219 NGL View in InterPro
5U5T A 180 - 219 NGL View in InterPro
B 180 - 219 NGL View in InterPro
5U62 A 180 - 219 NGL View in InterPro
B 180 - 219 NGL View in InterPro
5U69 A 180 - 219 NGL View in InterPro
5U6D A 180 - 219 NGL View in InterPro
5U8A A 180 - 219 NGL View in InterPro
5U8F A 180 - 219 NGL View in InterPro
5WG6 B 180 - 219 NGL View in InterPro
D 180 - 219 NGL View in InterPro
5WP3 A 180 - 219 NGL View in InterPro
5WUK A 180 - 219 NGL View in InterPro
6B3W E 166 - 205 NGL View in InterPro
F 166 - 205 NGL View in InterPro
6C23 L 180 - 219 NGL View in InterPro
6C24 L 180 - 219 NGL View in InterPro
6SFB A 180 - 219 NGL View in InterPro
B 180 - 219 NGL View in InterPro
6SFC A 180 - 219 NGL View in InterPro
B 180 - 219 NGL View in InterPro
6U4Y D 180 - 219 NGL View in InterPro
E 180 - 219 NGL View in InterPro
F 180 - 219 NGL View in InterPro
6W7F A 180 - 219 NGL View in InterPro
6W7G A 180 - 219 NGL View in InterPro
225 - 264 3IIW A 225 - 264 NGL View in InterPro
3IIY A 225 - 264 NGL View in InterPro
3IJ0 A 225 - 264 NGL View in InterPro
3IJ1 A 225 - 264 NGL View in InterPro
3IJC A 225 - 264 NGL View in InterPro
3JPX A 225 - 264 NGL View in InterPro
3JZG A 225 - 264 NGL View in InterPro
3JZH A 225 - 264 NGL View in InterPro
3JZN A 225 - 264 NGL View in InterPro
3K26 A 225 - 264 NGL View in InterPro
3K27 A 225 - 264 NGL View in InterPro
4W2R E 211 - 250 NGL View in InterPro
F 211 - 250 NGL View in InterPro
4X3E A 225 - 264 NGL View in InterPro
5GSA A 225 - 264 NGL View in InterPro
B 225 - 264 NGL View in InterPro
5H13 A 225 - 264 NGL View in InterPro
5H14 A 225 - 264 NGL View in InterPro
B 225 - 264 NGL View in InterPro
5H15 A 225 - 264 NGL View in InterPro
B 225 - 264 NGL View in InterPro
5H17 A 225 - 264 NGL View in InterPro
5H19 A 225 - 264 NGL View in InterPro
5H24 A 225 - 264 NGL View in InterPro
B 225 - 264 NGL View in InterPro
5H25 A 225 - 264 NGL View in InterPro
B 225 - 264 NGL View in InterPro
5HYN B 225 - 264 NGL View in InterPro
G 225 - 264 NGL View in InterPro
L 225 - 264 NGL View in InterPro
R 225 - 264 NGL View in InterPro
5IJ7 E 211 - 250 NGL View in InterPro
F 211 - 250 NGL View in InterPro
5IJ8 E 211 - 250 NGL View in InterPro
F 211 - 250 NGL View in InterPro
5K0M A 225 - 264 NGL View in InterPro
5LS6 B 225 - 264 NGL View in InterPro
E 225 - 264 NGL View in InterPro
H 225 - 264 NGL View in InterPro
K 225 - 264 NGL View in InterPro
5TTW A 225 - 264 NGL View in InterPro
C 225 - 264 NGL View in InterPro
5U5H A 225 - 264 NGL View in InterPro
5U5K A 225 - 264 NGL View in InterPro
5U5T A 225 - 264 NGL View in InterPro
B 225 - 264 NGL View in InterPro
5U62 A 225 - 264 NGL View in InterPro
B 225 - 264 NGL View in InterPro
5U69 A 225 - 264 NGL View in InterPro
5U6D A 225 - 264 NGL View in InterPro
5U8A A 225 - 264 NGL View in InterPro
5U8F A 225 - 264 NGL View in InterPro
5WG6 B 225 - 264 NGL View in InterPro
D 225 - 264 NGL View in InterPro
5WP3 A 225 - 264 NGL View in InterPro
5WUK A 225 - 264 NGL View in InterPro
6B3W E 211 - 250 NGL View in InterPro
F 211 - 250 NGL View in InterPro
6C23 L 225 - 264 NGL View in InterPro
6C24 L 225 - 264 NGL View in InterPro
6SFB A 225 - 264 NGL View in InterPro
B 225 - 264 NGL View in InterPro
6SFC A 225 - 264 NGL View in InterPro
B 225 - 264 NGL View in InterPro
6U4Y D 225 - 264 NGL View in InterPro
E 225 - 264 NGL View in InterPro
F 225 - 264 NGL View in InterPro
6W7F A 225 - 264 NGL View in InterPro
6W7G A 225 - 264 NGL View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;