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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: S4A4_MOUSE (O88343)

Summary

This is the summary of UniProt entry S4A4_MOUSE (O88343).

Description: Electrogenic sodium bicarbonate cotransporter 1
Source organism: Mus musculus (Mouse) (NCBI taxonomy ID 10090)
Length: 1079 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
low_complexity n/a 40 59
disorder n/a 42 73
disorder n/a 75 80
low_complexity n/a 76 87
disorder n/a 95 97
disorder n/a 106 111
Pfam Band_3_cyto 137 388
disorder n/a 145 146
disorder n/a 219 222
disorder n/a 235 262
disorder n/a 264 266
disorder n/a 269 275
disorder n/a 390 397
disorder n/a 400 431
low_complexity n/a 417 432
Pfam HCO3_cotransp 441 956
transmembrane n/a 469 492
transmembrane n/a 504 533
transmembrane n/a 553 571
transmembrane n/a 583 601
transmembrane n/a 688 705
transmembrane n/a 726 748
transmembrane n/a 777 797
transmembrane n/a 818 842
transmembrane n/a 878 897
transmembrane n/a 904 923
transmembrane n/a 955 986
low_complexity n/a 1008 1024
disorder n/a 1012 1033
disorder n/a 1058 1060
disorder n/a 1069 1071

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O88343. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEDEAVLDRG ASFLKHVCDE EEVEGHHTIY IGVHVPKSYR RRRRHKRKAG
50
51
HKEKKEKERI SENYSDKSDV ENADESSSSI LKPLISPAAE RIRFILGEED
100
101
DSPAPPQLFT ELDELLAVDG QEMEWKETAR WIKFEEKVEQ GGERWSKPHV
150
151
ATLSLHSLFE LRTCMEKGSI MLDREASSLP QLVEMIADHQ IETGLLKPDL
200
201
KDKVTYTLLR KHRHQTKKSN LRSLADIGKT VSSASRMFSN PDNGSPAMTH
250
251
RNLTSSSLND ISDKPEKDQL KNKFMKKLPR DAEASNVLVG EVDFLDTPFI
300
301
AFVRLQQAVM LGALTEVPVP TRFLFILLGP KGKAKSYHEI GRAIATLMSD
350
351
EVFHDIAYKA KDRHDLIAGI DEFLDEVIVL PPGEWDPTIR IEPPKSLPSS
400
401
DKRKNMYSGG ENVQMNGDTP HDGGHGGGGH GDCEELQRTG RFCGGLIKDI
450
451
KRKAPFFASD FYDALNIQAL SAILFIYLAT VTNAITFGGL LGDATDNMQG
500
501
VLESFLGTAV SGAIFCLFAG QPLTILSSTG PVLVFERLLF NFSKDHNFDY
550
551
LEFRLWIGLW SAFMCLVLVA TDASFLVQYF TRFTEEGFSS LISFIFIYDA
600
601
FKKMIKLADY YPINSDFKVG YNTHFSCACL PPDPVNLSVS NDTTLAPEDL
650
651
PTISSTDMYH NVTFDWAYLS KKECVKYGGK LVGNNCDFVP DITLMSFILF
700
701
LGTYTSSMAM KKFKTSRYFP TTARKLISDF AIILSILIFC VIDALVGVDT
750
751
PKLIVPSEFK PTSPNRGWFV PPFGGNPWWV CLAAAIPALL VTILIFMDQQ
800
801
ITAVIVNRKE HKLKKGAGYH LDLFWVAILM VVCSFMALPW YVAATVISIA
850
851
HIDSLKMETE TSAPGEQPKF LGVREQRVTG TLVFILTGLS VFMAPILKFI
900
901
PMPVLYGVFL YMGVASLNGV QFMDRLKLLL MPLKHQPDFI YLRHVPLRRV
950
951
HLFTFLQVLC LALLWILKST VAAIIFPVMI LALVAVRKGM DYLFSQHDLS
1000
1001
FLDDVIPEKD KKKKEDEKKK KKKKGSLDSD NDDSDCPYSE KVPSIKIPMD
1050
1051
IMEQQPFLSD NKPLDRERSS TFLERHTSC                       
1079
 

Show the unformatted sequence.

Checksums:
CRC64:DBC7C3DEBE10BE97
MD5:ce0f49d6ac0f00ca9c837c799e5f5e1c

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;