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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SCN8A_RAT (O88420)

Summary

This is the summary of UniProt entry SCN8A_RAT (O88420).

Description: Sodium channel protein type 8 subunit alpha
Source organism: Rattus norvegicus (Rat) (NCBI taxonomy ID 10116)
Length: 1978 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 2
disorder n/a 9 10
disorder n/a 16 18
disorder n/a 28 29
disorder n/a 33 57
transmembrane n/a 128 151
Pfam Ion_trans 131 422
transmembrane n/a 199 219
transmembrane n/a 254 274
transmembrane n/a 348 366
transmembrane n/a 387 414
coiled_coil n/a 411 449
disorder n/a 423 427
low_complexity n/a 423 434
disorder n/a 433 434
low_complexity n/a 433 452
disorder n/a 446 535
low_complexity n/a 473 492
low_complexity n/a 484 501
coiled_coil n/a 489 509
disorder n/a 540 543
Pfam Na_trans_cytopl 546 700
disorder n/a 551 554
disorder n/a 561 562
disorder n/a 566 571
disorder n/a 576 591
disorder n/a 594 600
low_complexity n/a 606 628
low_complexity n/a 701 712
Pfam Ion_trans 750 985
transmembrane n/a 752 770
transmembrane n/a 782 800
transmembrane n/a 820 841
low_complexity n/a 838 850
transmembrane n/a 862 890
low_complexity n/a 878 890
transmembrane n/a 920 937
transmembrane n/a 949 975
low_complexity n/a 963 985
Pfam Na_trans_assoc 989 1191
disorder n/a 1053 1064
low_complexity n/a 1060 1071
disorder n/a 1068 1072
disorder n/a 1105 1141
low_complexity n/a 1139 1151
disorder n/a 1144 1146
Pfam Ion_trans 1195 1472
transmembrane n/a 1197 1215
transmembrane n/a 1236 1255
transmembrane n/a 1267 1290
low_complexity n/a 1292 1307
transmembrane n/a 1311 1339
transmembrane n/a 1436 1462
low_complexity n/a 1436 1452
Pfam Ion_trans 1519 1775
transmembrane n/a 1521 1539
transmembrane n/a 1551 1569
transmembrane n/a 1581 1601
transmembrane n/a 1607 1626
low_complexity n/a 1617 1629
transmembrane n/a 1638 1666
low_complexity n/a 1738 1756
transmembrane n/a 1741 1764
disorder n/a 1874 1876
disorder n/a 1882 1886
Pfam IQ 1894 1914
disorder n/a 1919 1978
low_complexity n/a 1953 1972

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O88420. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAARLLAPPG PDSFKPFTPE SLANIERRIA ESKLKKPPKA DGSHREDDED
50
51
SKPKPNSDLE AGKSLPFIYG DIPQGLVAVP LEDFDPYYLT QKTFVVLNRG
100
101
KTLFRFSATP ALYILSPFNL IRRIAIKILI HSVFSMIIMC TILTNCVFMT
150
151
FSNPPEWSKN VEYTFTGIYT FESLVKIIAR GFCIDGFTFL RDPWNWLDFS
200
201
VIMMAYVTEF VDLGNVSALR TFRVLRALKT ISVIPGLKTI VGALIQSVKK
250
251
LSDVMILTVF CLSVFALIGL QLFMGNLRNK CVVWPINFNE SYLENGTRGF
300
301
DWEEYINNKT NFYMVPGMLE PLLCGNSSDA GQCPEGFQCM KAGRNPNYGY
350
351
TSFDTFSWAF LALFRLMTQD YWENLYQLTL RAAGKTYMIF FVLVIFVGSF
400
401
YLVNLILAVV AMAYEEQNQA TLEEAEQKEA EFKAMLEQLK KQQEEAQAAA
450
451
MATSAGTVSE DAIEEEGEDG VGSPRSSSEL SKLSSKSAKE RRNRRKKRKQ
500
501
KELSEGEEKG DPEKVFKSES EDGMRRKAFR LPDNRIGRKF SIMNQSLLSI
550
551
PGSPFLSRHN SKSSIFSFRG PGRFRDPGSE NEFADDEHST VEESEGRRDS
600
601
LFIPIRARER RSSYSGYSGY SQCSRSSRIF PSLRRSVKRN STVDCNGVVS
650
651
LIGPGSHIGR LLPEATTEVE IKKKGPGSLL VSMDQLASYG RKDRINSIMS
700
701
VVTNTLVEEL EESQRKCPPC WYKFANTFLI WECHPYWIKL KEIVNLIVMD
750
751
PFVDLAITIC IVLNTLFMAM EHHPMTPQFE HVLAVGNLVF TGIFTAEMFL
800
801
KLIAMDPYYY FQEGWNIFDG FIVSLSLMEL SLADVEGLSV LRSFRLLRVF
850
851
KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV GMQLFGKSYK
900
901
ECVCKINQEC KLPRWHMNDF FHSFLIVFRV LCGEWIETMW DCMEVAGQAM
950
951
CLIVFMMVMV IGNLVVLNLF LALLLSSFSA DNLAATDDDG EMNNLQISVI
1000
1001
RIKKGVAWTK VKVHAFMQAH FKQREADEVK PLDELYEKKA NCIANHTGVD
1050
1051
IHRNGDFQKN GNGTTSGIGS SVEKYIIDED HMSFINNPNL TVRVPIAVGE
1100
1101
SDFENLNTED VSSESDPEGS KDKLDDTSSS EGSTIDIKPE VEEVPVEQPE
1150
1151
EYLDPDACFT EGCVQRFKCC QVNIEEGLGK SWWILRKTCF LIVEHNWFET
1200
1201
FIIFMILLSS GALAFEDIYI EQRKTIRTIL EYADKVFTYI FILEMLLKWT
1250
1251
AYGFVKFFTN AWCWLDFLIV AVSLVSLIAN ALGYSELGAI KSLRTLRALR
1300
1301
PLRALSRFEG MRVVVNALVG AIPSIMNVLL VCLIFWLIFS IMGVNLFAGK
1350
1351
YHYCFNETSE IRFEIDIVNN KTDCEKLMEG NSTEIRWKNV KINFDNVGAG
1400
1401
YLALLQVATF KGWMDIMYAA VDSRKPDEQP DYEGNIYMYI YFVIFIIFGS
1450
1451
FFTLNLFIGV IIDNFNQQKK KFGGQDIFMT EEQKKYYNAM KKLGSKKPQK
1500
1501
PIPRPLNKIQ GIVFDFVTQQ AFDIVIMMLI CLNMVTMMVE TDTQSKQMEN
1550
1551
ILYWINLVFV IFFTCECVLK MFALRHYYFT IGWNIFDFVV VILSIVGMFL
1600
1601
ADIIEKYFVS PTLFRVIRLA RIGRILRLIK GAKGIRTLLF ALMMSLPALF
1650
1651
NIGLLLFLVM FIFSIFGMSN FAYVKHEAGI DDMFNFETFG NSMICLFQIT
1700
1701
TSAGWDGLLL PILNRPPDCS LDKEHPGSGF KGDCGNPSVG IFFFVSYIII
1750
1751
SFLIVVNMYI AIILENFSVA TEESADPLSE DDFETFYEIW EKFDPDATQF
1800
1801
IEYCKLADFA DALEHPLRVP KPNTIELIAM DLPMVSGDRI HCLDILFAFT
1850
1851
KRVLGDSGEL DILRQQMEER FVASNPSKVS YEPITTTLRR KQEEVSAVVL
1900
1901
QRAYRGHLAR RGFICRKMAS NKLENGGTHR DKKESTPSTA SLPSYDSVTK
1950
1951
PDKEKQQRAE EGRRERAKRQ KEVRESKC                        
1978
 

Show the unformatted sequence.

Checksums:
CRC64:9160843C5935B88B
MD5:e5ba71b671acb8ed6f19d392d84531d4

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;