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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DPYD_RAT (O89000)

Summary

This is the summary of UniProt entry DPYD_RAT (O89000).

Description: Dihydropyrimidine dehydrogenase [NADP(+)] EC=1.3.1.2
Source organism: Rattus norvegicus (Rat) (NCBI taxonomy ID 10116)
Length: 1025 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam Fer4_20 55 168
Pfam Pyr_redox_2 171 499
low_complexity n/a 375 386
Pfam DHO_dh 532 838
disorder n/a 755 758
disorder n/a 850 864
Pfam Fer4_21 946 1004

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O89000. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAGVLSRDAP DIESILALNP RIQAHATLRS TMAKKLDKKH WKRNTDKNCF
50
51
ICEKLENNFD DIKHTTLGER GALREAVRCL KCADAPCQKS CPTSLDIKSF
100
101
ITSIANKNYY GAAKLIFSDN PLGLTCGMVC PTSDLCVGGC NLHATEEGPI
150
151
NIGGLQQFAT EVFKAMNIPQ IRSPLLPPPE HMPEAYSAKI ALFGAGPASI
200
201
SCASFLARLG YSDITIFEKQ EYVGGLSTSE IPQFRLPYDV VNFEIELMKD
250
251
LGVKIICGKS ISTDEMTLST LKENGYKAAF IGIGLPEPKK DHIFQGLTQV
300
301
QGFYTSKDFL PLVAKGSKPG MCACHSPLPS VRGAVIVLGA GDTAFDCATS
350
351
ALRCGARRVF IVFRKGFANI RAVPEEMELA KEEKCEFLPF LSPRKVIVKD
400
401
GKIVGMQFVR TEQDETGNWV EDEEQIVRLK ADVVISPFGS VLDDPKVIEA
450
451
LSPIKFNRWG LPEVNPETMQ TSEPWVFAGG DVVGMANTTV ESVNDGKQAS
500
501
WYIHEYIQAQ YGALVPSQPT LPLFYTPVDL VDISVEMAGL RFPNPFGLAS
550
551
ATPATSTPMI RRAFEAGWGF ALTKTFSLDK DIVTNVSPRI IRGTTSGPLY
600
601
GPGQSSFLNI ELISEKTAAY WCHSVTELKA DFPDNILIAS IMCSYNKNDW
650
651
MELSKMAEAS GADALELNLS CPHGMGERGM GLACGQDPEL VRNICRWVRQ
700
701
SVRVPFFAKL TPNVTDIVSI ARAAKEGGAD GVTATNTVSG LMGLKADGSP
750
751
WPSVGSGKRT TYGGVSGTTI RPIALRAVTA IARALPGFPI LATGGIDSAE
800
801
SGLQFLHSGA SVLQVCSAIQ NQDFTVIEDY CTGLKALLYL KSIEELSDWD
850
851
GQSPPTMSHQ KGKPVPHIAE LMGQKLPSFG PYLERRKKIL AASKIRENDQ
900
901
NRACSPLQRK HFNSQKPIPA IKDVIGKSLQ YLGTFGELNI MEQVVALIDE
950
951
EMCINCGKCY MTCNDSGYQA IQFDPETHLP TVSDTCTGCT LCLSVCPIMD
1000
1001
CIRMVSRATP YEPKRGLPLA VKPVC                           
1025
 

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Checksums:
CRC64:07859E73D249828C
MD5:ef528e4563384990f8085ca2d1986fed

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;