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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RTN3_HUMAN (O95197)

Summary

This is the summary of UniProt entry RTN3_HUMAN (O95197).

Description: Reticulon-3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1032 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 34
low_complexity n/a 5 20
low_complexity n/a 12 38
low_complexity n/a 41 66
disorder n/a 66 67
disorder n/a 72 74
disorder n/a 84 87
disorder n/a 98 101
disorder n/a 108 113
disorder n/a 118 146
disorder n/a 155 156
disorder n/a 173 197
disorder n/a 202 208
disorder n/a 210 212
disorder n/a 219 221
disorder n/a 234 240
disorder n/a 244 245
disorder n/a 272 283
disorder n/a 285 295
disorder n/a 355 362
disorder n/a 370 378
disorder n/a 385 398
disorder n/a 401 465
disorder n/a 469 622
disorder n/a 638 662
disorder n/a 668 672
disorder n/a 677 681
disorder n/a 684 732
disorder n/a 736 737
disorder n/a 749 750
disorder n/a 754 768
Pfam Reticulon 844 1008
transmembrane n/a 864 887
transmembrane n/a 944 966
transmembrane n/a 972 994

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O95197. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAEPSAATQS HSISSSSFGA EPSAPGGGGS PGACPALGTK SCSSSCADSF
50
51
VSSSSSQPVS LFSTSQEGLS SLCSDEPSSE IMTSSFLSSS EIHNTGLTIL
100
101
HGEKSHVLGS QPILAKEGKD HLDLLDMKKM EKPQGTSNNV SDSSVSLAAG
150
151
VHCDRPSIPA SFPEHPAFLS KKIGQVEEQI DKETKNPNGV SSREAKTALD
200
201
ADDRFTLLTA QKPPTEYSKV EGIYTYSLSP SKVSGDDVIE KDSPESPFEV
250
251
IIDKAAFDKE FKDSYKESTD DFGSWSVHTD KESSEDISET NDKLFPLRNK
300
301
EAGRYPMSAL LSRQFSHTNA ALEEVSRCVN DMHNFTNEIL TWDLVPQVKQ
350
351
QTDKSSDCIT KTTGLDMSEY NSEIPVVNLK TSTHQKTPVC SIDGSTPITK
400
401
STGDWAEASL QQENAITGKP VPDSLNSTKE FSIKGVQGNM QKQDDTLAEL
450
451
PGSPPEKCDS LGSGVATVKV VLPDDHLKDE MDWQSSALGE ITEADSSGES
500
501
DDTVIEDITA DTSFENNKIQ AEKPVSIPSA VVKTGEREIK EIPSCEREEK
550
551
TSKNFEELVS DSELHQDQPD ILGRSPASEA ACSKVPDTNV SLEDVSEVAP
600
601
EKPITTENPK LPSTVSPNVF NETEFSLNVT TSAYLESLHG KNVKHIDDSS
650
651
PEDLIAAFTE TRDKGIVDSE RNAFKAISEK MTDFKTTPPV EVLHENESGG
700
701
SEIKDIGSKY SEQSKETNGS EPLGVFPTQG TPVASLDLEQ EQLTIKALKE
750
751
LGERQVEKST SAQRDAELPS EEVLKQTFTF APESWPQRSY DILERNVKNG
800
801
SDLGISQKPI TIRETTRVDA VSSLSKTELV KKHVLARLLT DFSVHDLIFW
850
851
RDVKKTGFVF GTTLIMLLSL AAFSVISVVS YLILALLSVT ISFRIYKSVI
900
901
QAVQKSEEGH PFKAYLDVDI TLSSEAFHNY MNAAMVHINR ALKLIIRLFL
950
951
VEDLVDSLKL AVFMWLMTYV GAVFNGITLL ILAELLIFSV PIVYEKYKTQ
1000
1001
IDHYVGIARD QTKSIVEKIQ AKLPGIAKKK AE                   
1032
 

Show the unformatted sequence.

Checksums:
CRC64:26B372B82BFC6361
MD5:29c3f677b56a26cb2e9d6b469774b16f

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;