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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: K2C75_HUMAN (O95678)

Summary

This is the summary of UniProt entry K2C75_HUMAN (O95678).

Description: Keratin, type II cytoskeletal 75
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 551 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 3 5
disorder n/a 8 11
Pfam Keratin_2_head 16 145
low_complexity n/a 26 56
low_complexity n/a 75 89
low_complexity n/a 92 120
disorder n/a 147 148
Pfam Filament 148 461
coiled_coil n/a 153 187
coiled_coil n/a 204 259
disorder n/a 353 355
disorder n/a 357 365
coiled_coil n/a 360 440
low_complexity n/a 476 511
low_complexity n/a 506 525
low_complexity n/a 531 548
disorder n/a 549 551

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O95678. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSRQSSITFQ SGSRRGFSTT SAITPAAGRS RFSSVSVARS AAGSGGLGRI
50
51
SSAGASFGSR SLYNLGGAKR VSINGCGSSC RSGFGGRASN RFGVNSGFGY
100
101
GGGVGGGFSG PSFPVCPPGG IQEVTVNQSL LTPLHLQIDP TIQRVRAEER
150
151
EQIKTLNNKF ASFIDKVRFL EQQNKVLETK WALLQEQGSR TVRQNLEPLF
200
201
DSYTSELRRQ LESITTERGR LEAELRNMQD VVEDFKVRYE DEINKRTAAE
250
251
NEFVALKKDV DAAYMNKVEL EAKVKSLPEE INFIHSVFDA ELSQLQTQVG
300
301
DTSVVLSMDN NRNLDLDSII AEVKAQYEDI ANRSRAEAES WYQTKYEELQ
350
351
VTAGRHGDDL RNTKQEISEM NRMIQRLRAE IDSVKKQCSS LQTAIADAEQ
400
401
RGELALKDAR AKLVDLEEAL QKAKQDMARL LREYQELMNI KLALDVEIAT
450
451
YRKLLEGEEC RLSGEGVSPV NISVVTSTLS SGYGSGSSIG GGNLGLGGGS
500
501
GYSFTTSGGH SLGAGLGGSG FSATSNRGLG GSGSSVKFVS TTSSSQKSYT
550
551
H                                                     
551
 

Show the unformatted sequence.

Checksums:
CRC64:9099CD53A0BAF1EB
MD5:f917d2be6fe121b72c93b3522ecb0924

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;