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34  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: A1AT_HUMAN (P01009)

Summary

This is the summary of UniProt entry A1AT_HUMAN (P01009).

Description: Alpha-1-antitrypsin {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 418 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 24
disorder n/a 28 46
Pfam Serpin 52 415

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P01009. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPSSVSWGIL LLAGLCCLVP VSLAEDPQGD AAQKTDTSHH DQDHPTFNKI
50
51
TPNLAEFAFS LYRQLAHQSN STNIFFSPVS IATAFAMLSL GTKADTHDEI
100
101
LEGLNFNLTE IPEAQIHEGF QELLRTLNQP DSQLQLTTGN GLFLSEGLKL
150
151
VDKFLEDVKK LYHSEAFTVN FGDTEEAKKQ INDYVEKGTQ GKIVDLVKEL
200
201
DRDTVFALVN YIFFKGKWER PFEVKDTEEE DFHVDQVTTV KVPMMKRLGM
250
251
FNIQHCKKLS SWVLLMKYLG NATAIFFLPD EGKLQHLENE LTHDIITKFL
300
301
ENEDRRSASL HLPKLSITGT YDLKSVLGQL GITKVFSNGA DLSGVTEEAP
350
351
LKLSKAVHKA VLTIDEKGTE AAGAMFLEAI PMSIPPEVKF NKPFVFLMIE
400
401
QNTKSPLFMG KVVNPTQK                                   
418
 

Show the unformatted sequence.

Checksums:
CRC64:7016555F273B7F16
MD5:2f600757c70cfcd2a1fa45463df654ce

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Serpin 377 - 415 1QMB B 353 - 391 NGL View in InterPro
378 - 415 1D5S B 354 - 391 NGL View in InterPro
383 - 415 1EZX B 359 - 391 NGL View in InterPro
3NDD B 359 - 391 NGL View in InterPro
7API B 359 - 391 NGL View in InterPro
8API B 359 - 391 NGL View in InterPro
9API B 359 - 391 NGL View in InterPro
385 - 415 3NDF B 361 - 391 NGL View in InterPro
6I3Z B 361 - 391 NGL View in InterPro
386 - 415 2D26 B 362 - 391 NGL View in InterPro
52 - 376 1QMB A 28 - 352 NGL View in InterPro
52 - 377 1D5S A 28 - 353 NGL View in InterPro
6I3Z A 28 - 353 NGL View in InterPro
52 - 382 1EZX A 28 - 358 NGL View in InterPro
2D26 A 28 - 358 NGL View in InterPro
3NDD A 28 - 358 NGL View in InterPro
3NDF A 28 - 358 NGL View in InterPro
7API A 28 - 358 NGL View in InterPro
8API A 28 - 358 NGL View in InterPro
9API A 28 - 358 NGL View in InterPro
52 - 415 1ATU A 28 - 391 NGL View in InterPro
1HP7 A 28 - 391 NGL View in InterPro
1IZ2 A 28 - 391 NGL View in InterPro
1KCT A 28 - 391 NGL View in InterPro
1OO8 A 28 - 391 NGL View in InterPro
1OPH A 28 - 391 NGL View in InterPro
1PSI A 28 - 391 NGL View in InterPro
1QLP A 28 - 391 NGL View in InterPro
2QUG A 28 - 391 NGL View in InterPro
3CWL A 28 - 391 NGL View in InterPro
3CWM A 28 - 391 NGL View in InterPro
3DRM A 28 - 391 NGL View in InterPro
3DRU A 28 - 391 NGL View in InterPro
B 28 - 391 NGL View in InterPro
C 28 - 391 NGL View in InterPro
3NE4 A 28 - 391 NGL View in InterPro
3T1P A 28 - 391 NGL View in InterPro
4PYW A 28 - 391 NGL View in InterPro
5IO1 A 28 - 391 NGL View in InterPro
B 28 - 391 NGL View in InterPro
5NBU A 28 - 391 NGL View in InterPro
5NBV A 28 - 391 NGL View in InterPro
6HX4 A 28 - 391 NGL View in InterPro
B 28 - 391 NGL View in InterPro
6I4V A 28 - 391 NGL View in InterPro
6I7U A 28 - 391 NGL View in InterPro
6IAY A 28 - 391 NGL View in InterPro
6ROD A 28 - 391 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;