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10  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TGFB1_HUMAN (P01137)

Summary

This is the summary of UniProt entry TGFB1_HUMAN (P01137).

Description: Transforming growth factor beta-1 proprotein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 390 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 29
low_complexity n/a 6 21
Pfam TGFb_propeptide 30 261
disorder n/a 60 61
disorder n/a 64 66
disorder n/a 88 100
low_complexity n/a 89 101
low_complexity n/a 149 162
Pfam TGF_beta 292 389

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P01137. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPPSGLRLLL LLLPLLWLLV LTPGRPAAGL STCKTIDMEL VKRKRIEAIR
50
51
GQILSKLRLA SPPSQGEVPP GPLPEAVLAL YNSTRDRVAG ESAEPEPEPE
100
101
ADYYAKEVTR VLMVETHNEI YDKFKQSTHS IYMFFNTSEL REAVPEPVLL
150
151
SRAELRLLRL KLKVEQHVEL YQKYSNNSWR YLSNRLLAPS DSPEWLSFDV
200
201
TGVVRQWLSR GGEIEGFRLS AHCSCDSRDN TLQVDINGFT TGRRGDLATI
250
251
HGMNRPFLLL MATPLERAQH LQSSRHRRAL DTNYCFSSTE KNCCVRQLYI
300
301
DFRKDLGWKW IHEPKGYHAN FCLGPCPYIW SLDTQYSKVL ALYNQHNPGA
350
351
SAAPCCVPQA LEPLPIVYYV GRKPKVEQLS NMIVRSCKCS           
390
 

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Checksums:
CRC64:75391614250288FE
MD5:d71fdec53480702b3083cce071822edb

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
TGF_beta 292 - 389 1KLA A 14 - 111 NGL View in InterPro
B 14 - 111 NGL View in InterPro
1KLC A 14 - 111 NGL View in InterPro
B 14 - 111 NGL View in InterPro
1KLD A 14 - 111 NGL View in InterPro
B 14 - 111 NGL View in InterPro
3KFD A 14 - 111 NGL View in InterPro
B 14 - 111 NGL View in InterPro
C 14 - 111 NGL View in InterPro
D 14 - 111 NGL View in InterPro
4KV5 A 14 - 111 NGL View in InterPro
B 14 - 111 NGL View in InterPro
C 14 - 111 NGL View in InterPro
D 14 - 111 NGL View in InterPro
5FFO C 263 - 360 NGL View in InterPro
D 263 - 360 NGL View in InterPro
G 263 - 360 NGL View in InterPro
H 263 - 360 NGL View in InterPro
5VQP A 263 - 360 NGL View in InterPro
6GFF B 292 - 389 NGL View in InterPro
D 292 - 389 NGL View in InterPro
F 292 - 389 NGL View in InterPro
H 292 - 389 NGL View in InterPro
TGFb_propeptide 106 - 261 6P7J A 76 - 231 NGL View in InterPro
242 - 251 6OM2 E 213 - 222 NGL View in InterPro
243 - 251 6OM2 F 214 - 222 NGL View in InterPro
30 - 261 6GFF A 30 - 261 NGL View in InterPro
E 30 - 261 NGL View in InterPro
32 - 261 5VQP A 3 - 232 NGL View in InterPro
6GFF C 32 - 261 NGL View in InterPro
G 32 - 261 NGL View in InterPro
34 - 261 5FFO H 5 - 232 NGL View in InterPro
36 - 261 5FFO D 7 - 232 NGL View in InterPro
37 - 261 5FFO C 8 - 232 NGL View in InterPro
39 - 261 5FFO G 10 - 232 NGL View in InterPro
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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.