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57  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: IL1B_HUMAN (P01584)

Summary

This is the summary of UniProt entry IL1B_HUMAN (P01584).

Description: Interleukin-1 beta {ECO:0000303|PubMed:1919436}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 269 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam IL1_propep 1 103
low_complexity n/a 93 105
Pfam IL1 147 264
disorder n/a 199 203

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P01584. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAEVPELASE MMAYYSGNED DLFFEADGPK QMKCSFQDLD LCPLDGGIQL
50
51
RISDHHYSKG FRQAASVVVA MDKLRKMLVP CPQTFQENDL STFFPFIFEE
100
101
EPIFFDTWDN EAYVHDAPVR SLNCTLRDSQ QKSLVMSGPY ELKALHLQGQ
150
151
DMEQQVVFSM SFVQGEESND KIPVALGLKE KNLYLSCVLK DDKPTLQLES
200
201
VDPKNYPKKK MEKRFVFNKI EINNKLEFES AQFPNWYIST SQAENMPVFL
250
251
GGTKGGQDIT DFTMQFVSS                                  
269
 

Show the unformatted sequence.

Checksums:
CRC64:9BF73C3673C6FD66
MD5:148ea68171ceac60d17423458e3a63cd

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
IL1 147 - 264 1HIB A 31 - 148 NGL View in InterPro
1I1B A 31 - 148 NGL View in InterPro
1IOB A 31 - 148 NGL View in InterPro
1ITB A 31 - 148 NGL View in InterPro
1L2H A 31 - 148 NGL View in InterPro
1S0L A 31 - 148 NGL View in InterPro
1T4Q A 31 - 148 NGL View in InterPro
1TOO A 31 - 148 NGL View in InterPro
1TP0 A 31 - 148 NGL View in InterPro
1TWE A 31 - 148 NGL View in InterPro
1TWM A 31 - 148 NGL View in InterPro
21BI A 31 - 148 NGL View in InterPro
2I1B A 31 - 148 NGL View in InterPro
2KH2 A 31 - 148 NGL View in InterPro
2NVH A 31 - 148 NGL View in InterPro
31BI A 31 - 148 NGL View in InterPro
3LTQ A 31 - 148 NGL View in InterPro
3O4O A 31 - 148 NGL View in InterPro
3POK A 31 - 161 NGL View in InterPro
41BI A 31 - 148 NGL View in InterPro
4DEP A 31 - 148 NGL View in InterPro
D 31 - 148 NGL View in InterPro
4G6J A 31 - 148 NGL View in InterPro
4G6M A 31 - 148 NGL View in InterPro
4GAF A 30 - 148 NGL View in InterPro
4GAI A 30 - 148 NGL View in InterPro
B 30 - 148 NGL View in InterPro
4I1B A 31 - 148 NGL View in InterPro
5BVP I 31 - 148 NGL View in InterPro
5I1B A 31 - 148 NGL View in InterPro
5MVZ U 31 - 148 NGL View in InterPro
V 31 - 148 NGL View in InterPro
5R7W A 31 - 148 NGL View in InterPro
5R85 A 31 - 148 NGL View in InterPro
5R86 A 31 - 148 NGL View in InterPro
5R87 A 31 - 148 NGL View in InterPro
5R88 A 31 - 148 NGL View in InterPro
5R89 A 31 - 148 NGL View in InterPro
5R8A A 31 - 148 NGL View in InterPro
5R8B A 31 - 148 NGL View in InterPro
5R8C A 31 - 148 NGL View in InterPro
5R8D A 31 - 148 NGL View in InterPro
5R8E A 31 - 148 NGL View in InterPro
5R8F A 31 - 148 NGL View in InterPro
5R8G A 31 - 148 NGL View in InterPro
5R8H A 31 - 148 NGL View in InterPro
5R8I A 31 - 148 NGL View in InterPro
5R8J A 31 - 148 NGL View in InterPro
5R8K A 31 - 148 NGL View in InterPro
5R8L A 31 - 148 NGL View in InterPro
5R8M A 31 - 148 NGL View in InterPro
5R8N A 31 - 148 NGL View in InterPro
5R8O A 31 - 148 NGL View in InterPro
5R8P A 31 - 148 NGL View in InterPro
5R8Q A 31 - 148 NGL View in InterPro
6I1B A 31 - 148 NGL View in InterPro
6Y8I A 31 - 148 NGL View in InterPro
6Y8M A 31 - 148 NGL View in InterPro
7I1B A 31 - 148 NGL View in InterPro
9ILB A 31 - 148 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;