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16  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DQA1_HUMAN (P01909)

Summary

This is the summary of UniProt entry DQA1_HUMAN (P01909).

Description: HLA class II histocompatibility antigen, DQ alpha 1 chain
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 254 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 23
Pfam MHC_II_alpha 29 108
Pfam C1-set 114 195
transmembrane n/a 221 239
low_complexity n/a 222 241

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P01909. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MILNKALMLG ALALTTVMSP CGGEDIVADH VASYGVNLYQ SYGPSGQYTH
50
51
EFDGDEQFYV DLGRKETVWC LPVLRQFRFD PQFALTNIAV LKHNLNSLIK
100
101
RSNSTAATNE VPEVTVFSKS PVTLGQPNIL ICLVDNIFPP VVNITWLSNG
150
151
HSVTEGVSET SFLSKSDHSF FKISYLTLLP SAEESYDCKV EHWGLDKPLL
200
201
KHWEPEIPAP MSELTETVVC ALGLSVGLVG IVVGTVFIIR GLRSVGASRH
250
251
QGPL                                                  
254
 

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Checksums:
CRC64:84E12B5A80E2A028
MD5:3020800c0f1a3e5f3da33f3eaa1f17fe

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
C1-set 114 - 195 1JK8 A 89 - 170 Show 3D Structure View in InterPro
1S9V A 89 - 170 Show 3D Structure View in InterPro
D 89 - 170 Show 3D Structure View in InterPro
2NNA A 89 - 170 Show 3D Structure View in InterPro
4GG6 A 89 - 170 Show 3D Structure View in InterPro
C 89 - 170 Show 3D Structure View in InterPro
4OZF A 89 - 170 Show 3D Structure View in InterPro
4OZG A 89 - 170 Show 3D Structure View in InterPro
C 89 - 170 Show 3D Structure View in InterPro
4OZH A 89 - 170 Show 3D Structure View in InterPro
C 89 - 170 Show 3D Structure View in InterPro
4OZI A 89 - 170 Show 3D Structure View in InterPro
C 89 - 170 Show 3D Structure View in InterPro
5KSA A 89 - 170 Show 3D Structure View in InterPro
5KSB A 89 - 170 Show 3D Structure View in InterPro
C 89 - 170 Show 3D Structure View in InterPro
5KSU A 89 - 170 Show 3D Structure View in InterPro
D 89 - 170 Show 3D Structure View in InterPro
5KSV A 89 - 170 Show 3D Structure View in InterPro
6MFF A 89 - 170 Show 3D Structure View in InterPro
6MFG A 89 - 170 Show 3D Structure View in InterPro
C 89 - 170 Show 3D Structure View in InterPro
6U3M A 89 - 170 Show 3D Structure View in InterPro
C 89 - 170 Show 3D Structure View in InterPro
6U3N A 89 - 170 Show 3D Structure View in InterPro
MHC_II_alpha 29 - 108 1JK8 A 4 - 83 Show 3D Structure View in InterPro
1S9V A 4 - 83 Show 3D Structure View in InterPro
D 4 - 83 Show 3D Structure View in InterPro
2NNA A 4 - 83 Show 3D Structure View in InterPro
4GG6 A 4 - 83 Show 3D Structure View in InterPro
C 4 - 83 Show 3D Structure View in InterPro
4OZF A 4 - 83 Show 3D Structure View in InterPro
4OZG A 4 - 83 Show 3D Structure View in InterPro
C 4 - 83 Show 3D Structure View in InterPro
4OZH A 4 - 83 Show 3D Structure View in InterPro
C 4 - 83 Show 3D Structure View in InterPro
4OZI A 4 - 83 Show 3D Structure View in InterPro
C 4 - 83 Show 3D Structure View in InterPro
5KSA A 4 - 83 Show 3D Structure View in InterPro
5KSB A 4 - 83 Show 3D Structure View in InterPro
C 4 - 83 Show 3D Structure View in InterPro
5KSU A 4 - 83 Show 3D Structure View in InterPro
D 4 - 83 Show 3D Structure View in InterPro
5KSV A 4 - 83 Show 3D Structure View in InterPro
6MFF A 4 - 83 Show 3D Structure View in InterPro
6MFG A 4 - 83 Show 3D Structure View in InterPro
C 4 - 83 Show 3D Structure View in InterPro
6U3M A 4 - 83 Show 3D Structure View in InterPro
C 4 - 83 Show 3D Structure View in InterPro
6U3N A 4 - 83 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;