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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MIS_HUMAN (P03971)

Summary

This is the summary of UniProt entry MIS_HUMAN (P03971).

Description: Muellerian-inhibiting factor
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 560 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 26
low_complexity n/a 4 22
disorder n/a 54 58
Pfam AMH_N 77 442
disorder n/a 142 154
low_complexity n/a 150 164
disorder n/a 159 162
disorder n/a 175 183
disorder n/a 210 213
disorder n/a 215 221
disorder n/a 227 229
disorder n/a 253 257
disorder n/a 261 289
low_complexity n/a 296 315
low_complexity n/a 308 321
disorder n/a 314 315
low_complexity n/a 336 358
disorder n/a 349 370
low_complexity n/a 374 391
low_complexity n/a 393 435
disorder n/a 439 455
Pfam TGF_beta 461 559

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P03971. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRDLPLTSLA LVLSALGALL GTEALRAEEP AVGTSGLIFR EDLDWPPGSP
50
51
QEPLCLVALG GDSNGSSSPL RVVGALSAYE QAFLGAVQRA RWGPRDLATF
100
101
GVCNTGDRQA ALPSLRRLGA WLRDPGGQRL VVLHLEEVTW EPTPSLRFQE
150
151
PPPGGAGPPE LALLVLYPGP GPEVTVTRAG LPGAQSLCPS RDTRYLVLAV
200
201
DRPAGAWRGS GLALTLQPRG EDSRLSTARL QALLFGDDHR CFTRMTPALL
250
251
LLPRSEPAPL PAHGQLDTVP FPPPRPSAEL EESPPSADPF LETLTRLVRA
300
301
LRVPPARASA PRLALDPDAL AGFPQGLVNL SDPAALERLL DGEEPLLLLL
350
351
RPTAATTGDP APLHDPTSAP WATALARRVA AELQAAAAEL RSLPGLPPAT
400
401
APLLARLLAL CPGGPGGLGD PLRALLLLKA LQGLRVEWRG RDPRGPGRAQ
450
451
RSAGATAADG PCALRELSVD LRAERSVLIP ETYQANNCQG VCGWPQSDRN
500
501
PRYGNHVVLL LKMQVRGAAL ARPPCCVPTA YAGKLLISLS EERISAHHVP
550
551
NMVATECGCR                                            
560
 

Show the unformatted sequence.

Checksums:
CRC64:D05DCEE4FEDF94C2
MD5:5a099152117263b990d5ea32843330fa

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;