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29  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: VWF_HUMAN (P04275)

Summary

This is the summary of UniProt entry VWF_HUMAN (P04275).

Description: von Willebrand factor
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 2813 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 22
low_complexity n/a 10 17
Pfam VWD 35 179
low_complexity n/a 204 214
Pfam C8 224 291
Pfam TIL 295 348
Pfam VWD 388 541
Pfam C8 583 648
low_complexity n/a 621 635
low_complexity n/a 630 641
Pfam TIL 652 707
Pfam TIL 776 827
Pfam VWD 867 1013
Pfam C8 1059 1126
Pfam TIL 1141 1196
Pfam VWA_N2 1198 1276
disorder n/a 1255 1256
Pfam VWA 1277 1452
low_complexity n/a 1405 1418
low_complexity n/a 1460 1471
disorder n/a 1468 1473
Pfam VWA 1498 1660
disorder n/a 1603 1605
Pfam VWA 1691 1862
low_complexity n/a 1795 1815
Pfam VWD 1950 2102
Pfam C8 2138 2199
Pfam VWC 2257 2327
low_complexity n/a 2413 2425
Pfam VWC 2431 2494
disorder n/a 2513 2516
Pfam VWC 2582 2644

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P04275. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MIPARFAGVL LALALILPGT LCAEGTRGRS STARCSLFGS DFVNTFDGSM
50
51
YSFAGYCSYL LAGGCQKRSF SIIGDFQNGK RVSLSVYLGE FFDIHLFVNG
100
101
TVTQGDQRVS MPYASKGLYL ETEAGYYKLS GEAYGFVARI DGSGNFQVLL
150
151
SDRYFNKTCG LCGNFNIFAE DDFMTQEGTL TSDPYDFANS WALSSGEQWC
200
201
ERASPPSSSC NISSGEMQKG LWEQCQLLKS TSVFARCHPL VDPEPFVALC
250
251
EKTLCECAGG LECACPALLE YARTCAQEGM VLYGWTDHSA CSPVCPAGME
300
301
YRQCVSPCAR TCQSLHINEM CQERCVDGCS CPEGQLLDEG LCVESTECPC
350
351
VHSGKRYPPG TSLSRDCNTC ICRNSQWICS NEECPGECLV TGQSHFKSFD
400
401
NRYFTFSGIC QYLLARDCQD HSFSIVIETV QCADDRDAVC TRSVTVRLPG
450
451
LHNSLVKLKH GAGVAMDGQD VQLPLLKGDL RIQHTVTASV RLSYGEDLQM
500
501
DWDGRGRLLV KLSPVYAGKT CGLCGNYNGN QGDDFLTPSG LAEPRVEDFG
550
551
NAWKLHGDCQ DLQKQHSDPC ALNPRMTRFS EEACAVLTSP TFEACHRAVS
600
601
PLPYLRNCRY DVCSCSDGRE CLCGALASYA AACAGRGVRV AWREPGRCEL
650
651
NCPKGQVYLQ CGTPCNLTCR SLSYPDEECN EACLEGCFCP PGLYMDERGD
700
701
CVPKAQCPCY YDGEIFQPED IFSDHHTMCY CEDGFMHCTM SGVPGSLLPD
750
751
AVLSSPLSHR SKRSLSCRPP MVKLVCPADN LRAEGLECTK TCQNYDLECM
800
801
SMGCVSGCLC PPGMVRHENR CVALERCPCF HQGKEYAPGE TVKIGCNTCV
850
851
CQDRKWNCTD HVCDATCSTI GMAHYLTFDG LKYLFPGECQ YVLVQDYCGS
900
901
NPGTFRILVG NKGCSHPSVK CKKRVTILVE GGEIELFDGE VNVKRPMKDE
950
951
THFEVVESGR YIILLLGKAL SVVWDRHLSI SVVLKQTYQE KVCGLCGNFD
1000
1001
GIQNNDLTSS NLQVEEDPVD FGNSWKVSSQ CADTRKVPLD SSPATCHNNI
1050
1051
MKQTMVDSSC RILTSDVFQD CNKLVDPEPY LDVCIYDTCS CESIGDCACF
1100
1101
CDTIAAYAHV CAQHGKVVTW RTATLCPQSC EERNLRENGY ECEWRYNSCA
1150
1151
PACQVTCQHP EPLACPVQCV EGCHAHCPPG KILDELLQTC VDPEDCPVCE
1200
1201
VAGRRFASGK KVTLNPSDPE HCQICHCDVV NLTCEACQEP GGLVVPPTDA
1250
1251
PVSPTTLYVE DISEPPLHDF YCSRLLDLVF LLDGSSRLSE AEFEVLKAFV
1300
1301
VDMMERLRIS QKWVRVAVVE YHDGSHAYIG LKDRKRPSEL RRIASQVKYA
1350
1351
GSQVASTSEV LKYTLFQIFS KIDRPEASRI TLLLMASQEP QRMSRNFVRY
1400
1401
VQGLKKKKVI VIPVGIGPHA NLKQIRLIEK QAPENKAFVL SSVDELEQQR
1450
1451
DEIVSYLCDL APEAPPPTLP PDMAQVTVGP GLLGVSTLGP KRNSMVLDVA
1500
1501
FVLEGSDKIG EADFNRSKEF MEEVIQRMDV GQDSIHVTVL QYSYMVTVEY
1550
1551
PFSEAQSKGD ILQRVREIRY QGGNRTNTGL ALRYLSDHSF LVSQGDREQA
1600
1601
PNLVYMVTGN PASDEIKRLP GDIQVVPIGV GPNANVQELE RIGWPNAPIL
1650
1651
IQDFETLPRE APDLVLQRCC SGEGLQIPTL SPAPDCSQPL DVILLLDGSS
1700
1701
SFPASYFDEM KSFAKAFISK ANIGPRLTQV SVLQYGSITT IDVPWNVVPE
1750
1751
KAHLLSLVDV MQREGGPSQI GDALGFAVRY LTSEMHGARP GASKAVVILV
1800
1801
TDVSVDSVDA AADAARSNRV TVFPIGIGDR YDAAQLRILA GPAGDSNVVK
1850
1851
LQRIEDLPTM VTLGNSFLHK LCSGFVRICM DEDGNEKRPG DVWTLPDQCH
1900
1901
TVTCQPDGQT LLKSHRVNCD RGLRPSCPNS QSPVKVEETC GCRWTCPCVC
1950
1951
TGSSTRHIVT FDGQNFKLTG SCSYVLFQNK EQDLEVILHN GACSPGARQG
2000
2001
CMKSIEVKHS ALSVELHSDM EVTVNGRLVS VPYVGGNMEV NVYGAIMHEV
2050
2051
RFNHLGHIFT FTPQNNEFQL QLSPKTFASK TYGLCGICDE NGANDFMLRD
2100
2101
GTVTTDWKTL VQEWTVQRPG QTCQPILEEQ CLVPDSSHCQ VLLLPLFAEC
2150
2151
HKVLAPATFY AICQQDSCHQ EQVCEVIASY AHLCRTNGVC VDWRTPDFCA
2200
2201
MSCPPSLVYN HCEHGCPRHC DGNVSSCGDH PSEGCFCPPD KVMLEGSCVP
2250
2251
EEACTQCIGE DGVQHQFLEA WVPDHQPCQI CTCLSGRKVN CTTQPCPTAK
2300
2301
APTCGLCEVA RLRQNADQCC PEYECVCDPV SCDLPPVPHC ERGLQPTLTN
2350
2351
PGECRPNFTC ACRKEECKRV SPPSCPPHRL PTLRKTQCCD EYECACNCVN
2400
2401
STVSCPLGYL ASTATNDCGC TTTTCLPDKV CVHRSTIYPV GQFWEEGCDV
2450
2451
CTCTDMEDAV MGLRVAQCSQ KPCEDSCRSG FTYVLHEGEC CGRCLPSACE
2500
2501
VVTGSPRGDS QSSWKSVGSQ WASPENPCLI NECVRVKEEV FIQQRNVSCP
2550
2551
QLEVPVCPSG FQLSCKTSAC CPSCRCERME ACMLNGTVIG PGKTVMIDVC
2600
2601
TTCRCMVQVG VISGFKLECR KTTCNPCPLG YKEENNTGEC CGRCLPTACT
2650
2651
IQLRGGQIMT LKRDETLQDG CDTHFCKVNE RGEYFWEKRV TGCPPFDEHK
2700
2701
CLAEGGKIMK IPGTCCDTCE EPECNDITAR LQYVKVGSCK SEVEVDIHYC
2750
2751
QGKCASKAMY SIDINDVQDQ CSCCSPTRTE PMQVALHCTN GSVVYHEVLN
2800
2801
AMECKCSPRK CSK                                        
2813
 

Show the unformatted sequence.

Checksums:
CRC64:D5C1C78360917C29
MD5:4f26adb6e954c8e065f64b10ac553f34

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
C8 1059 - 1126 6N29 A 1059 - 1126 NGL View in InterPro
B 1059 - 1126 NGL View in InterPro
TIL 1141 - 1196 6N29 A 1141 - 1196 NGL View in InterPro
B 1141 - 1196 NGL View in InterPro
776 - 827 2MHP A 15 - 66 NGL View in InterPro
2MHQ A 15 - 66 NGL View in InterPro
6N29 A 776 - 827 NGL View in InterPro
B 776 - 827 NGL View in InterPro
VWA 1277 - 1452 1AUQ A 514 - 689 NGL View in InterPro
1FNS A 514 - 689 NGL View in InterPro
1IJB A 514 - 689 NGL View in InterPro
1IJK A 514 - 689 NGL View in InterPro
1M10 A 514 - 689 NGL View in InterPro
1OAK A 514 - 689 NGL View in InterPro
1SQ0 A 514 - 689 NGL View in InterPro
1U0N A 514 - 689 NGL View in InterPro
1UEX C 514 - 689 NGL View in InterPro
3HXO A 514 - 689 NGL View in InterPro
3HXQ A 514 - 689 NGL View in InterPro
4C29 A 1277 - 1452 NGL View in InterPro
B 1277 - 1452 NGL View in InterPro
4C2A A 1277 - 1452 NGL View in InterPro
4C2B A 1277 - 1452 NGL View in InterPro
C 1277 - 1452 NGL View in InterPro
E 1277 - 1452 NGL View in InterPro
G 1277 - 1452 NGL View in InterPro
5BV8 A 1277 - 1452 NGL View in InterPro
1498 - 1660 3GXB A 1498 - 1660 NGL View in InterPro
B 1498 - 1660 NGL View in InterPro
3PPV A 1498 - 1660 NGL View in InterPro
3PPW A 1498 - 1660 NGL View in InterPro
3PPX A 1498 - 1660 NGL View in InterPro
3PPY A 1498 - 1660 NGL View in InterPro
3ZQK A 1498 - 1660 NGL View in InterPro
B 1498 - 1660 NGL View in InterPro
C 1498 - 1660 NGL View in InterPro
1691 - 1862 1AO3 A 6 - 177 NGL View in InterPro
B 6 - 177 NGL View in InterPro
1ATZ A 928 - 1099 NGL View in InterPro
B 928 - 1099 NGL View in InterPro
1FE8 A 928 - 1099 NGL View in InterPro
B 928 - 1099 NGL View in InterPro
C 928 - 1099 NGL View in InterPro
2ADF A 928 - 1099 NGL View in InterPro
4DMU B 1691 - 1862 NGL View in InterPro
D 1691 - 1862 NGL View in InterPro
F 1691 - 1862 NGL View in InterPro
H 1691 - 1862 NGL View in InterPro
J 1691 - 1862 NGL View in InterPro
L 1691 - 1862 NGL View in InterPro
VWA_N2 1198 - 1239 6N29 B 1198 - 1239 NGL View in InterPro
1198 - 1241 6N29 A 1198 - 1241 NGL View in InterPro
1261 - 1276 1AUQ A 498 - 513 NGL View in InterPro
1U0N A 498 - 513 NGL View in InterPro
5BV8 A 1261 - 1276 NGL View in InterPro
1263 - 1276 1IJB A 500 - 513 NGL View in InterPro
1264 - 1276 1UEX C 501 - 513 NGL View in InterPro
1265 - 1276 1IJK A 502 - 513 NGL View in InterPro
3HXQ A 502 - 513 NGL View in InterPro
1266 - 1276 4C29 A 1266 - 1276 NGL View in InterPro
B 1266 - 1276 NGL View in InterPro
4C2A A 1266 - 1276 NGL View in InterPro
1267 - 1276 4C2B A 1267 - 1276 NGL View in InterPro
E 1267 - 1276 NGL View in InterPro
1268 - 1276 1M10 A 505 - 513 NGL View in InterPro
4C2B C 1268 - 1276 NGL View in InterPro
1269 - 1276 1SQ0 A 506 - 513 NGL View in InterPro
4C2B G 1269 - 1276 NGL View in InterPro
1270 - 1276 1OAK A 507 - 513 NGL View in InterPro
3HXO A 507 - 513 NGL View in InterPro
1271 - 1276 1FNS A 508 - 513 NGL View in InterPro
VWD 867 - 1013 6N29 A 867 - 1013 NGL View in InterPro
B 867 - 1013 NGL View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.