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13  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SHBG_HUMAN (P04278)

Summary

This is the summary of UniProt entry SHBG_HUMAN (P04278).

Description: Sex hormone-binding globulin
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 402 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 29
low_complexity n/a 12 21
disorder n/a 32 34
disorder n/a 39 51
Pfam Laminin_G_1 75 205
disorder n/a 127 130
disorder n/a 211 213
disorder n/a 236 238
low_complexity n/a 286 311
low_complexity n/a 325 339
disorder n/a 386 402

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P04278. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MESRGPLATS RLLLLLLLLL LRHTRQGWAL RPVLPTQSAH DPPAVHLSNG
50
51
PGQEPIAVMT FDLTKITKTS SSFEVRTWDP EGVIFYGDTN PKDDWFMLGL
100
101
RDGRPEIQLH NHWAQLTVGA GPRLDDGRWH QVEVKMEGDS VLLEVDGEEV
150
151
LRLRQVSGPL TSKRHPIMRI ALGGLLFPAS NLRLPLVPAL DGCLRRDSWL
200
201
DKQAEISASA PTSLRSCDVE SNPGIFLPPG TQAEFNLRDI PQPHAEPWAF
250
251
SLDLGLKQAA GSGHLLALGT PENPSWLSLH LQDQKVVLSS GSGPGLDLPL
300
301
VLGLPLQLKL SMSRVVLSQG SKMKALALPP LGLAPLLNLW AKPQGRLFLG
350
351
ALPGEDSSTS FCLNGLWAQG QRLDVDQALN RSHEIWTHSC PQSPGNGTDA
400
401
SH                                                    
402
 

Show the unformatted sequence.

Checksums:
CRC64:5A3B1885E4E7A460
MD5:b99750bb4843976f3566d75a48c88676

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Laminin_G_1 75 - 205 1D2S A 46 - 176 NGL View in InterPro
1F5F A 46 - 176 NGL View in InterPro
1KDK A 46 - 176 NGL View in InterPro
1KDM A 46 - 176 NGL View in InterPro
1LHN A 46 - 176 NGL View in InterPro
1LHO A 46 - 176 NGL View in InterPro
1LHU A 46 - 176 NGL View in InterPro
1LHV A 46 - 176 NGL View in InterPro
1LHW A 46 - 176 NGL View in InterPro
6PYA A 46 - 176 NGL View in InterPro
6PYB A 46 - 176 NGL View in InterPro
6PYF A 46 - 176 NGL View in InterPro
6ULB A 46 - 176 NGL View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;