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27  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PERM_HUMAN (P05164)

Summary

This is the summary of UniProt entry PERM_HUMAN (P05164).

Description: Myeloperoxidase
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 745 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 48
low_complexity n/a 29 41
coiled_coil n/a 66 86
low_complexity n/a 106 116
Pfam An_peroxidase 173 718
disorder n/a 237 238

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P05164. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGVPFFSSLR CMVDLGPCWA GGLTAEMKLL LALAGLLAIL ATPQPSEGAA
50
51
PAVLGEVDTS LVLSSMEEAK QLVDKAYKER RESIKQRLRS GSASPMELLS
100
101
YFKQPVAATR TAVRAADYLH VALDLLERKL RSLWRRPFNV TDVLTPAQLN
150
151
VLSKSSGCAY QDVGVTCPEQ DKYRTITGMC NNRRSPTLGA SNRAFVRWLP
200
201
AEYEDGFSLP YGWTPGVKRN GFPVALARAV SNEIVRFPTD QLTPDQERSL
250
251
MFMQWGQLLD HDLDFTPEPA ARASFVTGVN CETSCVQQPP CFPLKIPPND
300
301
PRIKNQADCI PFFRSCPACP GSNITIRNQI NALTSFVDAS MVYGSEEPLA
350
351
RNLRNMSNQL GLLAVNQRFQ DNGRALLPFD NLHDDPCLLT NRSARIPCFL
400
401
AGDTRSSEMP ELTSMHTLLL REHNRLATEL KSLNPRWDGE RLYQEARKIV
450
451
GAMVQIITYR DYLPLVLGPT AMRKYLPTYR SYNDSVDPRI ANVFTNAFRY
500
501
GHTLIQPFMF RLDNRYQPME PNPRVPLSRV FFASWRVVLE GGIDPILRGL
550
551
MATPAKLNRQ NQIAVDEIRE RLFEQVMRIG LDLPALNMQR SRDHGLPGYN
600
601
AWRRFCGLPQ PETVGQLGTV LRNLKLARKL MEQYGTPNNI DIWMGGVSEP
650
651
LKRKGRVGPL LACIIGTQFR KLRDGDRFWW ENEGVFSMQQ RQALAQISLP
700
701
RIICDNTGIT TVSKNNIFMS NSYPRDFVNC STLPALNLAS WREAS     
745
 

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Checksums:
CRC64:348B1CE0A11038B4
MD5:b9bdc97b1d569bc1391a701daa2bee86

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
An_peroxidase 173 - 269 5FIW B 7 - 103 NGL View in InterPro
5QJ2 A 7 - 103 NGL View in InterPro
D 7 - 103 NGL View in InterPro
F 7 - 103 NGL View in InterPro
H 7 - 103 NGL View in InterPro
5QJ3 A 7 - 103 NGL View in InterPro
D 7 - 103 NGL View in InterPro
5WDJ D 7 - 103 NGL View in InterPro
6WXZ A 7 - 103 NGL View in InterPro
D 7 - 103 NGL View in InterPro
6WY0 A 7 - 103 NGL View in InterPro
H 7 - 103 NGL View in InterPro
6WY7 A 7 - 103 NGL View in InterPro
D 7 - 103 NGL View in InterPro
6WYD A 7 - 103 NGL View in InterPro
D 7 - 103 NGL View in InterPro
F 7 - 103 NGL View in InterPro
H 7 - 103 NGL View in InterPro
173 - 270 1CXP A 7 - 104 NGL View in InterPro
B 7 - 104 NGL View in InterPro
1D2V A 7 - 104 NGL View in InterPro
B 7 - 104 NGL View in InterPro
1D5L A 7 - 104 NGL View in InterPro
B 7 - 104 NGL View in InterPro
1D7W A 7 - 104 NGL View in InterPro
B 7 - 104 NGL View in InterPro
1DNU A 7 - 104 NGL View in InterPro
B 7 - 104 NGL View in InterPro
1DNW A 7 - 104 NGL View in InterPro
B 7 - 104 NGL View in InterPro
1MHL A 7 - 104 NGL View in InterPro
B 7 - 104 NGL View in InterPro
1MYP A 7 - 104 NGL View in InterPro
B 7 - 104 NGL View in InterPro
3ZS0 A 7 - 104 NGL View in InterPro
B 7 - 104 NGL View in InterPro
3ZS1 A 7 - 104 NGL View in InterPro
B 7 - 104 NGL View in InterPro
4DL1 A 7 - 104 NGL View in InterPro
B 7 - 104 NGL View in InterPro
E 7 - 104 NGL View in InterPro
F 7 - 104 NGL View in InterPro
I 7 - 104 NGL View in InterPro
J 7 - 104 NGL View in InterPro
M 7 - 104 NGL View in InterPro
N 7 - 104 NGL View in InterPro
4EJX B 7 - 104 NGL View in InterPro
5WDJ A 7 - 104 NGL View in InterPro
6WY0 D 7 - 104 NGL View in InterPro
F 7 - 104 NGL View in InterPro
6WY5 A 7 - 104 NGL View in InterPro
D 7 - 104 NGL View in InterPro
173 - 271 4C1M A 7 - 105 NGL View in InterPro
B 7 - 105 NGL View in InterPro
5FIW A 7 - 105 NGL View in InterPro
173 - 272 3F9P A 7 - 106 NGL View in InterPro
173 - 273 3F9P B 7 - 107 NGL View in InterPro
173 - 718 5MFA A 173 - 718 NGL View in InterPro
5UZU A 173 - 718 NGL View in InterPro
6AZP A 173 - 718 NGL View in InterPro
6BMT A 173 - 718 NGL View in InterPro
279 - 718 1CXP C 113 - 552 NGL View in InterPro
D 113 - 552 NGL View in InterPro
1D2V C 113 - 552 NGL View in InterPro
D 113 - 552 NGL View in InterPro
1D5L C 113 - 552 NGL View in InterPro
D 113 - 552 NGL View in InterPro
1D7W C 113 - 552 NGL View in InterPro
D 113 - 552 NGL View in InterPro
1DNU C 113 - 552 NGL View in InterPro
D 113 - 552 NGL View in InterPro
1DNW C 113 - 552 NGL View in InterPro
D 113 - 552 NGL View in InterPro
1MHL C 113 - 552 NGL View in InterPro
D 113 - 552 NGL View in InterPro
3F9P C 113 - 552 NGL View in InterPro
D 113 - 552 NGL View in InterPro
3ZS0 C 113 - 552 NGL View in InterPro
D 113 - 552 NGL View in InterPro
3ZS1 C 113 - 552 NGL View in InterPro
D 113 - 552 NGL View in InterPro
4C1M C 113 - 552 NGL View in InterPro
D 113 - 552 NGL View in InterPro
4DL1 C 113 - 552 NGL View in InterPro
D 113 - 552 NGL View in InterPro
G 113 - 552 NGL View in InterPro
H 113 - 552 NGL View in InterPro
K 113 - 552 NGL View in InterPro
L 113 - 552 NGL View in InterPro
O 113 - 552 NGL View in InterPro
P 113 - 552 NGL View in InterPro
4EJX D 113 - 552 NGL View in InterPro
5QJ2 B 113 - 552 NGL View in InterPro
E 113 - 552 NGL View in InterPro
G 113 - 552 NGL View in InterPro
I 113 - 552 NGL View in InterPro
5QJ3 E 113 - 552 NGL View in InterPro
5WDJ B 113 - 552 NGL View in InterPro
E 113 - 552 NGL View in InterPro
6WXZ E 113 - 552 NGL View in InterPro
6WY0 E 113 - 552 NGL View in InterPro
I 113 - 552 NGL View in InterPro
6WY5 E 113 - 552 NGL View in InterPro
6WY7 B 113 - 552 NGL View in InterPro
6WYD B 113 - 552 NGL View in InterPro
E 113 - 552 NGL View in InterPro
G 113 - 552 NGL View in InterPro
I 113 - 552 NGL View in InterPro
280 - 718 1MYP C 114 - 552 NGL View in InterPro
D 114 - 552 NGL View in InterPro
5FIW C 114 - 552 NGL View in InterPro
D 114 - 552 NGL View in InterPro
5QJ3 B 114 - 552 NGL View in InterPro
6WXZ B 114 - 552 NGL View in InterPro
6WY0 B 114 - 552 NGL View in InterPro
G 114 - 552 NGL View in InterPro
6WY5 B 114 - 552 NGL View in InterPro
6WY7 E 114 - 552 NGL View in InterPro
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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.