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38  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ADRB2_HUMAN (P07550)

Summary

This is the summary of UniProt entry ADRB2_HUMAN (P07550).

Description: Beta-2 adrenergic receptor
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 413 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
transmembrane n/a 31 58
Pfam 7tm_1 50 326
transmembrane n/a 70 96
transmembrane n/a 108 129
transmembrane n/a 150 169
transmembrane n/a 198 219
transmembrane n/a 275 295
transmembrane n/a 307 327
low_complexity n/a 350 359
disorder n/a 361 365
disorder n/a 392 394
disorder n/a 398 401

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P07550. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGQPGNGSAF LLAPNGSHAP DHDVTQERDE VWVVGMGIVM SLIVLAIVFG
50
51
NVLVITAIAK FERLQTVTNY FITSLACADL VMGLAVVPFG AAHILMKMWT
100
101
FGNFWCEFWT SIDVLCVTAS IETLCVIAVD RYFAITSPFK YQSLLTKNKA
150
151
RVIILMVWIV SGLTSFLPIQ MHWYRATHQE AINCYANETC CDFFTNQAYA
200
201
IASSIVSFYV PLVIMVFVYS RVFQEAKRQL QKIDKSEGRF HVQNLSQVEQ
250
251
DGRTGHGLRR SSKFCLKEHK ALKTLGIIMG TFTLCWLPFF IVNIVHVIQD
300
301
NLIRKEVYIL LNWIGYVNSG FNPLIYCRSP DFRIAFQELL CLRRSSLKAY
350
351
GNGYSSNGNT GEQSGYHVEQ EKENKLLCED LPGTEDFVGH QGTVPSDNID
400
401
SQGRNCSTND SLL                                        
413
 

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Checksums:
CRC64:408C22731C6EDFBE
MD5:3e9d25347d93e5c2b71f7d8151dd1e9c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
7tm_1 50 - 326 2R4R A 50 - 326 NGL View in InterPro
2R4S A 50 - 326 NGL View in InterPro
2RH1 A 50 - 326 NGL View in InterPro
3D4S A 50 - 326 NGL View in InterPro
3KJ6 A 50 - 326 NGL View in InterPro
3NY8 A 50 - 326 NGL View in InterPro
3NY9 A 50 - 326 NGL View in InterPro
3NYA A 50 - 326 NGL View in InterPro
3P0G A 50 - 326 NGL View in InterPro
3PDS A 50 - 326 NGL View in InterPro
3SN6 R 50 - 326 NGL View in InterPro
4GBR A 50 - 298 NGL View in InterPro
4LDE A 1050 - 1326 NGL View in InterPro
4LDL A 1050 - 1326 NGL View in InterPro
4LDO A 1050 - 1326 NGL View in InterPro
4QKX A 1050 - 1326 NGL View in InterPro
5D5A A 50 - 326 NGL View in InterPro
5D5B A 50 - 326 NGL View in InterPro
5D6L A 50 - 326 NGL View in InterPro
5JQH A 1050 - 1326 NGL View in InterPro
B 1050 - 1326 NGL View in InterPro
5X7D A 50 - 326 NGL View in InterPro
6E67 A 50 - 326 NGL View in InterPro
B 50 - 326 NGL View in InterPro
6KR8 A 50 - 326 NGL View in InterPro
6MXT A 1050 - 1326 NGL View in InterPro
6N48 A 1050 - 1326 NGL View in InterPro
6NI3 R 50 - 326 NGL View in InterPro
6OBA A 50 - 326 NGL View in InterPro
6PRZ A 50 - 326 NGL View in InterPro
6PS0 A 50 - 326 NGL View in InterPro
6PS1 A 50 - 326 NGL View in InterPro
6PS2 A 50 - 326 NGL View in InterPro
6PS3 A 50 - 326 NGL View in InterPro
6PS4 A 50 - 326 NGL View in InterPro
6PS5 A 50 - 326 NGL View in InterPro
6PS6 A 50 - 326 NGL View in InterPro
7BZ2 R 50 - 326 NGL View in InterPro
7DHI R 50 - 326 NGL View in InterPro
7DHR R 50 - 326 NGL View in InterPro
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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.