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16  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NEP_HUMAN (P08473)

Summary

This is the summary of UniProt entry NEP_HUMAN (P08473).

Description: Neprilysin
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 750 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 7 15
transmembrane n/a 29 52
low_complexity n/a 29 48
Pfam Peptidase_M13_N 79 483
coiled_coil n/a 269 289
disorder n/a 284 286
low_complexity n/a 489 507
low_complexity n/a 515 526
Pfam Peptidase_M13 543 749

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P08473. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGKSESQMDI TDINTPKPKK KQRWTPLEIS LSVLVLLLTI IAVTMIALYA
50
51
TYDDGICKSS DCIKSAARLI QNMDATTEPC TDFFKYACGG WLKRNVIPET
100
101
SSRYGNFDIL RDELEVVLKD VLQEPKTEDI VAVQKAKALY RSCINESAID
150
151
SRGGEPLLKL LPDIYGWPVA TENWEQKYGA SWTAEKAIAQ LNSKYGKKVL
200
201
INLFVGTDDK NSVNHVIHID QPRLGLPSRD YYECTGIYKE ACTAYVDFMI
250
251
SVARLIRQEE RLPIDENQLA LEMNKVMELE KEIANATAKP EDRNDPMLLY
300
301
NKMTLAQIQN NFSLEINGKP FSWLNFTNEI MSTVNISITN EEDVVVYAPE
350
351
YLTKLKPILT KYSARDLQNL MSWRFIMDLV SSLSRTYKES RNAFRKALYG
400
401
TTSETATWRR CANYVNGNME NAVGRLYVEA AFAGESKHVV EDLIAQIREV
450
451
FIQTLDDLTW MDAETKKRAE EKALAIKERI GYPDDIVSND NKLNNEYLEL
500
501
NYKEDEYFEN IIQNLKFSQS KQLKKLREKV DKDEWISGAA VVNAFYSSGR
550
551
NQIVFPAGIL QPPFFSAQQS NSLNYGGIGM VIGHEITHGF DDNGRNFNKD
600
601
GDLVDWWTQQ SASNFKEQSQ CMVYQYGNFS WDLAGGQHLN GINTLGENIA
650
651
DNGGLGQAYR AYQNYIKKNG EEKLLPGLDL NHKQLFFLNF AQVWCGTYRP
700
701
EYAVNSIKTD VHSPGNFRII GTLQNSAEFS EAFHCRKNSY MNPEKKCRVW
750
751
                                                      
750
 

Show the unformatted sequence.

Checksums:
CRC64:BCF3827C39898630
MD5:8dc8bb79c513dfe6843cb591b957a81d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Peptidase_M13 543 - 749 1DMT A 542 - 748 NGL View in InterPro
1R1H A 542 - 748 NGL View in InterPro
1R1I A 542 - 748 NGL View in InterPro
1R1J A 542 - 748 NGL View in InterPro
1Y8J A 542 - 748 NGL View in InterPro
2QPJ A 542 - 748 NGL View in InterPro
2YB9 A 542 - 748 NGL View in InterPro
4CTH A 542 - 748 NGL View in InterPro
5JMY A 542 - 748 NGL View in InterPro
B 542 - 748 NGL View in InterPro
6GID A 542 - 748 NGL View in InterPro
6SH1 AAA 542 - 748 NGL View in InterPro
CCC 542 - 748 NGL View in InterPro
6SH2 AAA 542 - 748 NGL View in InterPro
6SUK A 542 - 748 NGL View in InterPro
6SVY A 542 - 748 NGL View in InterPro
6THP A 542 - 748 NGL View in InterPro
B 542 - 748 NGL View in InterPro
6XVP A 542 - 748 NGL View in InterPro
Peptidase_M13_N 79 - 483 1DMT A 78 - 482 NGL View in InterPro
1R1H A 78 - 482 NGL View in InterPro
1R1I A 78 - 482 NGL View in InterPro
1R1J A 78 - 482 NGL View in InterPro
1Y8J A 78 - 482 NGL View in InterPro
2QPJ A 78 - 482 NGL View in InterPro
2YB9 A 78 - 482 NGL View in InterPro
4CTH A 78 - 482 NGL View in InterPro
5JMY A 78 - 482 NGL View in InterPro
B 78 - 482 NGL View in InterPro
6GID A 78 - 482 NGL View in InterPro
6SH1 AAA 78 - 482 NGL View in InterPro
CCC 78 - 482 NGL View in InterPro
6SH2 AAA 78 - 482 NGL View in InterPro
6SUK A 78 - 482 NGL View in InterPro
6SVY A 78 - 482 NGL View in InterPro
6THP A 78 - 482 NGL View in InterPro
B 78 - 482 NGL View in InterPro
6XVP A 78 - 482 NGL View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;