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21  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ROA1_HUMAN (P09651)

Summary

This is the summary of UniProt entry ROA1_HUMAN (P09651).

Description: Heterogeneous nuclear ribonucleoprotein A1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 372 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 11
Pfam RRM_1 16 85
disorder n/a 74 96
Pfam RRM_1 107 176
disorder n/a 178 210
low_complexity n/a 190 320
disorder n/a 213 216
disorder n/a 221 225
disorder n/a 227 235
disorder n/a 239 241
disorder n/a 247 248
disorder n/a 254 286
disorder n/a 292 294
disorder n/a 298 303
Pfam HnRNPA1 307 344
disorder n/a 310 313
disorder n/a 317 321
disorder n/a 323 337
low_complexity n/a 330 345
disorder n/a 339 372
low_complexity n/a 355 369

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P09651. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSKSESPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN
50
51
TKRSRGFGFV TYATVEEVDA AMNARPHKVD GRVVEPKRAV SREDSQRPGA
100
101
HLTVKKIFVG GIKEDTEEHH LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF
150
151
VTFDDHDSVD KIVIQKYHTV NGHNCEVRKA LSKQEMASAS SSQRGRSGSG
200
201
NFGGGRGGGF GGNDNFGRGG NFSGRGGFGG SRGGGGYGGS GDGYNGFGND
250
251
GGYGGGGPGY SGGSRGYGSG GQGYGNQGSG YGGSGSYDSY NNGGGGGFGG
300
301
GSGSNFGGGG SYNDFGNYNN QSSNFGPMKG GNFGGRSSGP YGGGGQYFAK
350
351
PRNQGGYGGS SSSSSYGSGR RF                              
372
 

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Checksums:
CRC64:A06683571C6C109F
MD5:635b53c9fc307302b28ffb8f156a36b4

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
HnRNPA1 307 - 344 7BX7 A 255 - 292 NGL View in InterPro
B 255 - 292 NGL View in InterPro
C 255 - 292 NGL View in InterPro
D 255 - 292 NGL View in InterPro
E 255 - 292 NGL View in InterPro
F 255 - 292 NGL View in InterPro
315 - 341 2H4M D 263 - 289 NGL View in InterPro
319 - 341 2H4M C 267 - 289 NGL View in InterPro
RRM_1 107 - 176 1HA1 A 106 - 175 NGL View in InterPro
1L3K A 107 - 176 NGL View in InterPro
1PGZ A 107 - 176 NGL View in InterPro
1PO6 A 107 - 176 NGL View in InterPro
1U1K A 107 - 176 NGL View in InterPro
1U1L A 107 - 176 NGL View in InterPro
1U1M A 107 - 176 NGL View in InterPro
1U1N A 107 - 176 NGL View in InterPro
1U1O A 107 - 176 NGL View in InterPro
1U1P A 107 - 176 NGL View in InterPro
1U1Q A 107 - 176 NGL View in InterPro
1U1R A 107 - 176 NGL View in InterPro
1UP1 A 107 - 176 NGL View in InterPro
2LYV A 107 - 176 NGL View in InterPro
2UP1 A 107 - 176 NGL View in InterPro
4YOE A 107 - 176 NGL View in InterPro
5MPL A 107 - 176 NGL View in InterPro
6DCL A 107 - 176 NGL View in InterPro
B 107 - 176 NGL View in InterPro
16 - 85 1HA1 A 15 - 84 NGL View in InterPro
1L3K A 16 - 85 NGL View in InterPro
1PGZ A 16 - 85 NGL View in InterPro
1PO6 A 16 - 85 NGL View in InterPro
1U1K A 16 - 85 NGL View in InterPro
1U1L A 16 - 85 NGL View in InterPro
1U1M A 16 - 85 NGL View in InterPro
1U1N A 16 - 85 NGL View in InterPro
1U1O A 16 - 85 NGL View in InterPro
1U1P A 16 - 85 NGL View in InterPro
1U1Q A 16 - 85 NGL View in InterPro
1U1R A 16 - 85 NGL View in InterPro
1UP1 A 16 - 85 NGL View in InterPro
2LYV A 16 - 85 NGL View in InterPro
2UP1 A 16 - 85 NGL View in InterPro
4YOE A 16 - 85 NGL View in InterPro
5MPG A 16 - 85 NGL View in InterPro
6DCL A 16 - 85 NGL View in InterPro
B 16 - 85 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;