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19  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RU2A_HUMAN (P09661)

Summary

This is the summary of UniProt entry RU2A_HUMAN (P09661).

Description: U2 small nuclear ribonucleoprotein A'
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 255 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam LRR_9 1 175
disorder n/a 162 163
disorder n/a 173 175
disorder n/a 178 206
disorder n/a 222 255
low_complexity n/a 240 249

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P09661. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVKLTAELIE QAAQYTNAVR DRELDLRGYK IPVIENLGAT LDQFDAIDFS
50
51
DNEIRKLDGF PLLRRLKTLL VNNNRICRIG EGLDQALPCL TELILTNNSL
100
101
VELGDLDPLA SLKSLTYLSI LRNPVTNKKH YRLYVIYKVP QVRVLDFQKV
150
151
KLKERQEAEK MFKGKRGAQL AKDIARRSKT FNPGAGLPTD KKKGGPSPGD
200
201
VEAIKNAIAN ASTLAEVERL KGLLQSGQIP GRERRSGPTD DGEEEMEEDT
250
251
VTNGS                                                 
255
 

Show the unformatted sequence.

Checksums:
CRC64:25902F07992B7209
MD5:c670ea9b64a5bf99ec36726c49c50863

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
LRR_9 2 - 162 6QDV W 2 - 162 Show 3D Structure View in InterPro
2 - 163 1A9N A 2 - 163 Show 3D Structure View in InterPro
5MQF W 2 - 163 Show 3D Structure View in InterPro
5O9Z z 2 - 163 Show 3D Structure View in InterPro
5XJC o 2 - 163 Show 3D Structure View in InterPro
5YZG o 2 - 163 Show 3D Structure View in InterPro
5Z56 o 2 - 163 Show 3D Structure View in InterPro
5Z57 o 2 - 163 Show 3D Structure View in InterPro
5Z58 o 2 - 163 Show 3D Structure View in InterPro
6AH0 o 2 - 163 Show 3D Structure View in InterPro
6AHD o 2 - 163 Show 3D Structure View in InterPro
6FF7 W 2 - 163 Show 3D Structure View in InterPro
6ICZ o 2 - 163 Show 3D Structure View in InterPro
6ID0 o 2 - 163 Show 3D Structure View in InterPro
6ID1 o 2 - 163 Show 3D Structure View in InterPro
6QX9 2A 2 - 163 Show 3D Structure View in InterPro
6Y53 a 2 - 163 Show 3D Structure View in InterPro
6Y5Q a 2 - 163 Show 3D Structure View in InterPro
2 - 175 1A9N C 2 - 175 Show 3D Structure View in InterPro
7A5P W 2 - 175 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;